Using the documentary research technique, this paper outlines certain aspects of Ukraine-Poland cross-border mediation interaction in the context of contemporary threats. In addition, it points out the main contemporary threats, which affect the cross-border interaction of Ukraine and Poland. It characterizes such threats as nuclear danger, environmental problems, humanitarian crisis, economic threats and food shortages. It points out that there are internal threats to Poland in connection with the war in Ukraine, the spread of infectious diseases, including COVID-19, due to the large number of refugees, the threat to food security, the threat to Poland's economic stability and poverty. It is shown that Poland interacts with Ukraine on all urgent issues: helps citizens seeking temporary protection, sends humanitarian aid, strengthens and stimulates market relations. It is concluded that all this led to increased cross-border interaction between the countries. The relevance of alternative types of conflict resolution, such as mediation, is highlighted. The scope of cross-border mediation is presented, the current state of mediation is analyzed and conclusions are drawn on the need for further development of this institution.