International Nosocomial Infection Control Consortium (INICC) report, data summary of 36 countries, for 2004-2009

Rosenthal, Víctor D.; Hu, Bijie; Maki, Dennis G.; Mehta, Yatin; Apisarnthanarak, Anucha; Medeiros, Eduardo Alexandrino; Leblebicioğlu, Hakan; Fisher, Dale; Álvarez-Moreno, Carlos; Khader, Ilham Abu; González-Martínez, Marisela del Rocío; Cuéllar, Luis; Navoa-Ng, Josephine Anne; Abouqal, Rédouane; Garcell, Humberto Guanche; Mitrev, Zan; García, María Catalina Pírez; Hamdi, Asma; Dueñas, Lourdes; Cancel, Elsie; Gurskis, Vaidotas; Расслан, Оссама; Ahmed, Altaf; Kanj, Souha S.; Ugalde, Olber Chavarría; Mapp, Trudell; Raka, Lul; Meng, Cheong Yuet; Thư, Le Thi Anh; Ghazal, Sameeh; Gikas, Achilleas; Narváez, Leonardo Pazmiño; Mejía, Nepomuceno; Hadjieva, N.; Elanbya, May Osman Gamar; Siritt, María Eugenia Guzmán; Jayatilleke, Kushlani

doi:10.1016/j.ajic.2011.05.020

Cited by 521 publications

(507 citation statements)

References 35 publications

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“…중환자실 환 자의 15~30%에서 병원감염이 발생하며, 일반 병동에 비해 약 3배가량 높은 것으로 보고되었다 (Kwak et al, 2010;Rosenthal et al, 2010) (Rosenthal et al, 2010). 특히 다른 감염에 비해 이로 인한 치 사율이 27~30%로 상대적으로 높은 것으로 보고되었다 (CDC, 2002;Rosenthal et al, 2010). 중환자실 병원감염은 사망률의 증가뿐만 아니라, 재원기간의 연장의 결과로 이어지면서 환자 개인 및 가족 차원은 물론 국가 차원의 막대한 의료비 지출 증가 의 결과를 가져오기 때문에, 이에 대한 효율적인 관리 여부는 중환자실의 질 평가의 중요한 척도가 되고 있다 (Hatler et al, 2006;Labeau, Vereecke, Vandijck, Claes, & Blot, 2008).…”

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Level of Knowledge on Evidence-based Infection Control and Influencing Factors on Performance among Nurses in Intensive Care Unit

Yoo

Hur

et al. 2012

Korean J Adult Nurs

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Purpose: This study was to identify the level of knowledge and performances on evidence-based infection control and influencing factors on performance among nurses in intensive care unit. Methods: A descriptive crosssectional survey design was used. Two hundred thirty-nine nurses at intensive care units were conveniently recruited from seven hospitals located in Seoul and Kyounggi province. Data were collected with a questionnaire survey about evidence-based infection control. Data were analyzed using SPSS/WIN 17.0 program. Results: Both level of knowledge (mean 9.15 out of 19) on preventing ventilator-associated pneumonia and central venous catheter induced bloodstream infection, and performance on evidence-based infection control (1.94 out of 4) were moderate. Performance of evidence-based practice for infection control was related to reading research articles regularly, professional satisfaction, and taken education course. Conclusion: These results indicate that systematic and organizational strategies for enhancing evidence-based infection control are needed to improve quality of intensive nursing care.

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Level of Knowledge on Evidence-based Infection Control and Influencing Factors on Performance among Nurses in Intensive Care Unit

Yoo

Hur

et al. 2012

Korean J Adult Nurs

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“…18 A habilidade de identificar acuradamente microorganismos hospitalares é fundamental para qualquer sistema de vigilância em saúde, pois as informações geradas nos laboratórios de microbiologia condicionam as ações de controle, bem como influenciam as políti-cas e diretrizes dos programas institucionais e governamentais. 19 Com a emergência das candidíases invasivas em pacientes imunocomprometidos, tem havido um crescente interesse pelos antifúngicos, bem como pelos métodos laboratoriais de detecção da susceptibilidade que, indubitavelmente, auxiliam na escolha da melhor droga a ser empregada e/ou na análise de eventuais fracassos terapêuticos. 20 Em resumo, o presente trabalho contribuiu para o conhecimento da ocorrência das espécies de Candida isoladas de hemoculturas no HCSL de Pouso Alegre-MG.…”

Section: Discussionunclassified

Ocorrência e Perfil de Suscetibilidade de Candida sp em hemoculturas de um hospital universitário

Teixeira-Loyola

Fernandes

Barbosa

et al. 2013

Medicina (Ribeirão Preto)

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O gênero Candida é responsável por infecções associadas à fungemias hospitalares, principalmente em setores críticos. Objetivos: avaliar a ocorrência de Candida sp de hemoculturas do Laboratório de Análises Clínicas, do HCSL de Pouso Alegre, M G e avaliar o perfil de suscetibilidade frente a anfotericina B, itraconazol, fluconazol e voriconazol. Metodologia: Foi realizado um estudo descritivo de julho de 2009 á julho de 2010, onde foram avaliadas todas as hemoculturas do HCSL deste período. Os fungos isolados das hemoculturas foram identificados por metodologia clássica e automatizada. O teste de suscetibilidade foi realizado pela técnica de microdiluição em caldo segundo o documento CLSI M27-A3. Resultados: Foram avaliadas 1388 amostras sendo 108 amostras positivas, e destas, 10 fúngicas.A ocorrência fúngica foi: UTI adulto (4), UTI Neonatal (5) e Enfermaria Masculina (1). Foram identificadas Candida albicans (5) e Candida parapsilosis (4), e Candida sp (1). Todos os micro-organismos apresentaram sensibilidade frente aos antifúngicos testados. Conclusão: O percentual de positividade para candidemia observada neste estudo (1,38%) é similar aos estudos comparativos como pudemos observar na incidência em unidades de terapia intensiva. Vale destacar que a ocorrência é superior à observada em trabalhos internacionais.

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“…Then, we computed the probability of death with delayed therapy by multiplying the relative risk of mortality (converted from the odds ratio) with delayed therapy by the probability of death in patients receiving timely treatment. For instance, Rosenthal and colleagues reported that 25% of patients died with VAP (23). Combining estimates reported by Vazquez-Guillamet and colleagues (19) and Rosenthal and colleagues (23), we calculated the probability of death as 18% in ventilated patients with VAP receiving timely treatment and 43% in patients receiving delayed treatment.…”

Section: Model Inputsmentioning

confidence: 96%

Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients

Tsalik

Hudson

et al. 2016

Annals ATS

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Rationale: Limitations in methods for the rapid diagnosis of hospitalacquired infections often delay initiation of effective antimicrobial therapy. New diagnostic approaches offer potential clinical and cost-related improvements in the management of these infections.Objectives: We developed a decision modeling framework to assess the potential cost-effectiveness of a rapid biomarker assay to identify hospital-acquired infection in high-risk patients earlier than standard diagnostic testing. Methods:The framework includes parameters representing rates of infection, rates of delayed appropriate therapy, and impact of delayed therapy on mortality, along with assumptions about diagnostic test characteristics and their impact on delayed therapy and length of stay. Parameter estimates were based on contemporary, published studies and supplemented with data from a four-site, observational, clinical study. Extensive sensitivity analyses were performed. The base-case analysis assumed 17.6% of ventilated patients and 11.2% of nonventilated patients develop hospital-acquired infection and that 28.7% of patients with hospital-acquired infection experience delays in appropriate antibiotic therapy with standard care. We assumed this percentage decreased by 50% (to 14.4%) among patients with true-positive results and increased by 50% (to 43.1%) among patients with false-negative results using a hypothetical biomarker assay. Cost of testing was set at $110/d. Measurements and Main Results:In the base-case analysis, among ventilated patients, daily diagnostic testing starting on admission reduced inpatient mortality from 12.3 to 11.9% and increased mean costs by $1,640 per patient, resulting in an incremental cost-effectiveness ratio of $21,389 per life-year saved. Among nonventilated patients, inpatient mortality decreased from 7.3 to 7.1% and costs increased by $1,381 with diagnostic testing. The resulting incremental cost-effectiveness ratio was $42,325 per life-year saved. Threshold analyses revealed the probabilities of developing hospital-acquired infection in ventilated and nonventilated patients could be as low as 8.4 and 9.8%, respectively, to maintain incremental cost-effectiveness ratios less than $50,000 per life-year saved.Conclusions: Development and use of serial diagnostic testing that reduces the proportion of patients with delays in appropriate antibiotic therapy for hospital-acquired infections could reduce inpatient mortality. The model presented here offers a costeffectiveness framework for future test development.

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International Nosocomial Infection Control Consortium (INICC) report, data summary of 36 countries, for 2004-2009

Cited by 521 publications

References 35 publications

Level of Knowledge on Evidence-based Infection Control and Influencing Factors on Performance among Nurses in Intensive Care Unit

Level of Knowledge on Evidence-based Infection Control and Influencing Factors on Performance among Nurses in Intensive Care Unit

Ocorrência e Perfil de Suscetibilidade de Candida sp em hemoculturas de um hospital universitário

Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients

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