International Pediatric Sepsis Consensus Conference: Definitions for Sepsis and Organ Dysfunction in Pediatrics

Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis

“…The considerable heterogeneity regarding the definition of neonatal sepsis observed among the studies included in our review illustrates the lack of a universally acceptable definition of neonatal sepsis, particularly for the clinically septic but culture-negative newborns [9]. Although in neonatology the concept of clinical sepsis is widely used and considerable attempts have been made [24], a uniform definition for this common diagnosis is still lacking. This can be a cause of variability in the criteria for the definition of neonatal sepsis used in the studies that evaluate clinically diagnosed sepsis.…”

“…If healthy neonates were included in the non-septic group, the study population was considered as non-representative. The acceptable reference standard consisted of diagnostic criteria for neonatal sepsis matching those presented in the International Pediatric Sepsis Consensus conference [24]. Partial and differential verification biases were considered to have been avoided if all the included children were evaluated with the same reference standard method used in each study, regardless of the PCT results.…”

Corticosteroid exposure in pediatric acute respiratory distress syndrome

“…milrinone (lg/kg/min) 9 10. Non-pulmonary organ failures at time of PARDS diagnosis were identified using standard definitions for children [24]. The designation of ''immunocompromised'' required presence of an immunocompromising diagnosis (oncologic, immunologic, rheumatologic, or transplant) and active immunosuppressive chemotherapy, or a congenital immunodeficiency [25,26].…”

“…To test associations in more homogenous subgroups, we assessed the association between corticosteroid exposure [24 h and outcome in immunocompetent children, in patients with PARDS resulting from a pulmonary or non-pulmonary infection requiring vasopressor support (and therefore meeting criteria for septic shock [24]), and in children with reactive airway disease or lung disease of prematurity (Supplementary Table 4). In no subgroup was benefit seen with corticosteroids.…”

The number of failing organs predicts non-invasive ventilation failure in children with ALI/ARDS

“…Cardiovascular, neurologic, haematologic, renal and hepatic failure were defined according to organ dysfunction criteria of the International Pediatric Sepsis Consensus [20].…”