International safety assessment of pesticides: Dithiocarbamate pesticides, ETU, and PTU—A review and update

Vettorazzi, Gaston; Almeida, Waldemar F.; Burin, G.J.; Jaeger, Robert B.; Puga, F.R.; Rahde, Alberto Furtado; Reyes, Felix G. R.; Schvartsman, S

doi:10.1002/tcm.1770150608

Cited by 68 publications

(25 citation statements)

References 19 publications

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“…The main representatives of this group are dithyocarbamates (mancoceb, maneb, thyram, ziram, metyram, propineb, zineb, ethylen-and propilenthyourea) [27]. Their property is a weak genotoxicity and the capacity to induce thyroid tumors.…”

Section: Goitrogenic Pesticidesmentioning

confidence: 99%

Nongenotoxic (epigenetic) carcinogens: Pesticides as an example. A critical review

Rakitsky¹,

Koblyakov

Turusov

2000

Teratog. Carcinog. Mutagen.

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The following groups of pesticides are considered in this review by supposed mechanisms of their carcinogenicity: hepatocarcinogenic pesticides, pesticides - peroxisome proliferators, pesticides as endocrine disruptors, goitrogenic pesticides, pesticides producing sustained cell proliferation and some others. With very rare exceptions, pesticides do not react with DNA directly and the mechanisms of their carcinogenicity are, in general, similar to those of other nongenotoxic (epigenetic) carcinogens, namely: promotion of spontaneous initiation, cytotoxicity with sustained cell proliferation, oxidative stress, formation of activated receptors and some others. Genotoxicity of pesticides varies from its complete absence (propiconazol as an example) to a very pronounced one (captafol) with remaining compounds in between. These two compounds demonstrate full correlation between genotoxicity and carcinogenicity (or their absence). Many pesticides give positive results in some tests for genotoxicity but these results are frequently controversial, not readily reproducible, or obtained only at toxic dose levels. The weak genotoxicity of the majority of pesticides is easily explainable by their rather severe testing before their introduction into practical use. The above mechanisms are threshold-based and therefore pesticides are regulated through NOEL/safety factor. There exist examples of lack of correlation between genotoxicity and carcinogenicity: some pesticides are genotoxic (although not strongly) but noncarcinogenic, others are considered as nongenotoxic but are strongly carcinogenic (chlorothalonil, acetochlor). The general scheme of the promoters' effect is presented in which an important role is attributed to the cytochrome P-450 induction (some pesticides are the cytochrome P-450 inducers), formation of reactive oxygen species and peroxitome proliferation. Teratogenesis Carcinog. Mutagen. 20:229-240, 2000.

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Section: Goitrogenic Pesticidesmentioning

confidence: 99%

Nongenotoxic (epigenetic) carcinogens: Pesticides as an example. A critical review

Rakitsky¹,

Koblyakov

Turusov

2000

Teratog. Carcinog. Mutagen.

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“…They are also used to manage resistance and to broaden the spectrum of activity along with the modern systemic fungicides. DTCs are also used clinically for the treatment of chronic alcoholism and as anticancer and antitoxic drug agents [1][2][3][4] . Ferbam [Fe(III) tris{dimethyldithiocarbamate}], [{(CH 3 ) 2 NCS 2 } 3 Fe] is an agricultural dithiocarbamate fungicide used on a wide variety of plant fungi and diseases.…”

Section: Introductionmentioning

confidence: 99%

Preconcentration of Ferbam [Fe(III) tris(dimethyldithiocarbamate)] Using 1-(2-Pyridylazo)-2-naphthol Modified β-Cyclodextrin Polymer

2014

Chem Sci Trans

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Abstract:In this study, β-Cyclodextrin polymer functionalized by 1-(2-pyridylazo)-2-naphthol (PAN) was synthesized and the resulting modified polymer was used for the preconcentration of Fe(III) tris(dimethyldithiocarbamate) by converting it into Fe(III)-PAN-β-CDP complex. For the described method, the effect of some analytical parameters, such as pH, sample volume, contact time and volume of the eluent, on the recovery of Fe(III) tris(dimethyldithiocarbamate) were investigated. The recovery values were found to be ≥95%. The developed method was utilized for the preconcentration and determination of Ferbam in different water samples.

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“…Further intensive investigation of the category of ethylene bisdithiocarbamate base pesticides is urgently needed. However, there are not many schemes, which are sensitive enough to meet the requirement of Joint FAO/WHO Meeting of Pesticide Residues (JMPRs) for the detection of ethylene bisdithiocarbamate [4].…”

Section: Introductionmentioning

confidence: 99%

Determination of an Ethylene Bisdithiocarbamate Based Pesticide (Nabam) by Cobalt Phthalocyanine Modified Carbon Ink Electrode

Lin

Wang

2004

Electroanalysis

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A phthalocyanine based sensor, for anodic detection of sodium ethylene bisdithiocarbamate (Nabam) by coating a mixture of cobalt phthalocyanine (CoPC) modified carbon ink on the surface of a glassy carbon electrode, has been described. The modified ink was prepared by mixing three percent of cobalt phthalocyanine into carbon ink and then diluting the mixture with cyclohexanone in w/w ratio of 1/9. A suitable portion (or 1 mL) of ink mixture was then dipcoated on a rotating disk glassy carbon electrode. The modified ink electrode was air-dried for 15 mins before use. In comparison to the bare ink electrode on which the oxidation of Nabam takes place at 300 mV (vs. 3 M Ag/AgCl), the oxidation potential (À 125 mV) of Nabam at the CoPC modified ink decreases significantly. A typical calibration plot of Nabam proportionally increases over the concentration range of 2.5 to 36 mM (R 0.9990). The detection limit is estimated about 28.8 nM (S/N 3) and its response time (between 10% to 90% of steady-state response) is about 5.3 s at the injection of 5 mM Nabam. The sensitivity requirement of JMPR meeting (Joint FAO/WHO Meeting on Pesticide Residues) for ethylene bisdithiocarbamates (EBDCs) is achieved by this proposed scheme.

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International safety assessment of pesticides: Dithiocarbamate pesticides, ETU, and PTU—A review and update

Cited by 68 publications

References 19 publications

Nongenotoxic (epigenetic) carcinogens: Pesticides as an example. A critical review

Nongenotoxic (epigenetic) carcinogens: Pesticides as an example. A critical review

Preconcentration of Ferbam [Fe(III) tris(dimethyldithiocarbamate)] Using 1-(2-Pyridylazo)-2-naphthol Modified β-Cyclodextrin Polymer

Determination of an Ethylene Bisdithiocarbamate Based Pesticide (Nabam) by Cobalt Phthalocyanine Modified Carbon Ink Electrode

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