“…Nanoscale gas bubbles are important to many industry-related research fields, such as nanoscopic cleaning, − controlling slip in microfluidics, − mineral flotation, − wastewater treatment, ,,, biomedical and chemical industries, etc. − Different kinds of nanobubbles in the aforementioned applications usually exhibit distinguished physical and chemical properties because their activities are highly correlated with their unique condition, ,, lifespan, − size, , and stability. − It is well known that nanoscale gas bubbles mainly include surface nanobubbles and bulk nanobubbles. ,, Surface nanobubbles − are nanoscale gaseous domains aggregated on the hydrophobic/hydrophilic substrates and can survive for several days. Their existence was first predicted by Parker et al and imaged directly in 2000 by Lou et al and Ishida et al using tapping mode atomic force microscopy. , However, the existence of bulk nanobubbles still remains controversial because of the lack of direct and sensitive detecting techniques. , There is much skepticism associated with the existence and stability of bulk nanobubbles.…”