International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology

Mehta, Ravindra L.; Cerdá, Jorge; Burdmann, Emmanuel A.; Tonelli, Marcello; García-García, Guillermo; Jha, Vivekanand; Susantitaphong, Paweena; Rocco, Michael V.; Vanholder, Raymond; Sever, Mehmet Şükrü; Cruz, Dinna N.; Jaber, Bertrand L.; Lameire, Norbert; Lombardi, Raúl; Lewington, Andrew; Feehally, John; Finkelstein, Fredric O.; Levin, Nathan W.; Pannu, Neesh; Thomas, Bernadette; Aronoff-Spencer, Eliah; Remuzzi, Giuseppe

doi:10.1016/s0140-6736(15)60126-x

Cited by 907 publications

(846 citation statements)

References 180 publications

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“…1 Recognizing this, the International Society of Nephrology (ISN) recently set a goal of eliminating preventable or treatable deaths from AKI by 2025, the "0 by 25" initiative. 2 Implementation of this program in low-resource settings (LRSs) presents major challenges for this initiative for a variety of reasons.…”

Section: Introductionmentioning

confidence: 99%

Acute kidney injury: risk factors and management challenges in developing countries

Ponce¹,

Balbi²

2016

IJNRD

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Acute kidney injury (AKI) is a major global health problem in both developed and developing nations, negatively affecting patient morbidity and responsible for an estimated 1.4 million deaths per year. Although the International Society of Nephrology set a goal of eliminating preventable deaths from AKI by 2025, implementation of this program in developing countries presents major challenges not only because of the lack of resources but also because of the scarce data addressing the epidemiology and causes of AKI in developing countries, the limited health care resources to diagnose and treat AKI, and the poor awareness of the impact of AKI on patient outcomes.

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Section: Introductionmentioning

confidence: 99%

Acute kidney injury: risk factors and management challenges in developing countries

Ponce¹,

Balbi²

2016

IJNRD

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“…Menschen jedes Jahr von einem ANV betroffen und es wird angenommen, dass hierdurch jährlich 1,7 Mio. Todesfälle verursacht werden [15]. Die derzeit aktuellste Version der Behandlungsempfehlungen des ANV stellen die Kidney-Disease-Improving-GlobalOutcomes(KDIGO)-Leitlinien aus dem Jahr 2012 dar.…”

Section: Nierenersatztherapie Im Akuten Nierenversagenunclassified

Nierenersatztherapie im akuten Nierenversagen

Klein

Joannidis

2017

Med Klin Intensivmed Notfmed

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Nierenersatztherapie im akuten NierenversagenTrotz weltweiter Forschungsbemühun-gen in den letzten Jahren zählt das akute Nierenversagen (ANV) bzw. die akute Nierenschädigung ("acute kidney injury", AKI) unverändert zu einer der Komplikationen auf Intensivstationen, die mit hoher Morbidität und Mortalität einhergehen. Im Rahmen der multinationalen AKI-EPI-Studie wurde bei 57,3 % (95 %-Konfidenzintervall [KI] 55,0-29,6) der Intensivpatienten ein ANV festgestellt [7]. Andere Studien gaben bei diesem Patientenkollektiv eine Inzidenz des ANV von 20-50 % an [4,24]. Weltweit sind 13,3 Mio. Menschen jedes Jahr von einem ANV betroffen und es wird angenommen, dass hierdurch jährlich 1,7 Mio. Todesfälle verursacht werden [15]. Die derzeit aktuellste Version der Behandlungsempfehlungen des ANV stellen die Kidney-Disease-Improving-GlobalOutcomes(KDIGO)-Leitlinien aus dem Jahr 2012 dar. Auf diesen basiert auch die derzeit allgemein gültige Einteilung der Stadien des ANV. Eine Zunahme der Mortalität kann bei steigendem Schweregrad der Nierenschädigung beobachtet werden (KDIGO 1 -Odds-Ratio, OR: 2,19; 95%-KI: 1, 35;18;04;[7]). Im Durchschnitt benötigen 5-13 % der Intensivpatienten eine Nierenersatztherapie, das entspricht etwa 25 % der Patienten mit ANV [7,19,30].

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“…Treating and preventing malnutrition and diarrheal disease in developing countries by water and sanitation interventions should be a public health priority to reduce child mortality but also global CKD prevalence. The 0by25 initiative of the International Society of Nephrology aims at achieving no preventable and treatable deaths from AKI by 2025 [42]. Raising awareness of AKI, performing inexpensive, easy, and accurate diagnostic tests (measurement of serum creatinine, assessment of urinary sediment and volume status), improved clinical nephrology training, appropriate fluid administration, and availability of affordable, usually peritoneal, dialysis, will be needed to achieve this ambitious goal.…”

Section: What's Next?mentioning

confidence: 99%

Inequalities in access to pediatric ESRD care: a global health challenge

Harambat

Ekulu

2015

Pediatr Nephrol

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The increasing attention paid to chronic kidney disease (CKD) as a major cause of mortality and disability, as well as the advances in management of CKD in children, have created a growing demand for pediatric renal replacement therapy (RRT) worldwide. A study by Koch Nogueira and colleagues of children on the transplant waiting list showed large disparities in access to pediatric kidney transplantation between regions in Brazil. This finding raises a wider question about inequalities in access to CKD care in children. Here we review the available data on the global burden of end-stage renal disease in children, the need for pediatric RRT, and its actual provision worldwide. We focus on inequalities in access to renal care for children that currently exist between and within countries. Reduction in worldwide inequalities in access to RRT in children remains a challenge, which requires greater awareness and effective interventions and policies.

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International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology

Cited by 907 publications

References 180 publications

Acute kidney injury: risk factors and management challenges in developing countries

Acute kidney injury: risk factors and management challenges in developing countries

Nierenersatztherapie im akuten Nierenversagen

Inequalities in access to pediatric ESRD care: a global health challenge

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