International Society of Urological Pathology (ISUP)-Grade Grouping in Prostatic Adenocarcinoma and its Prognostic Implications

Hashmi, Atif Ali; Iftikhar, Syeda N; Munawar, Shahzeb; Ahmed, Omer; Yaqeen, Syed Rafay; Asghar, Ishaq Azeem; Irfan, Muhammad; Ali, Javaria; Edhi, Muhammad Muzzammil; Hashmi, Shoaib Naiyar

doi:10.1080/07357907.2021.2019263

Cited by 1 publication

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If these GG3 patients are included in the high-risk prostate cancer group, the diagnostic performance of the SUV max could be significantly improved, which again indirectly confirmed the significance of GG3. These patients have a worse than GG2 patients, so we considered GG3 patients to PPC with worse prognosis [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

The value of 68Ga-PSMA PET/CT in the diagnosis of intracapsular prostate cancer with a poor prognosis

Wang,

Song,

Yang

et al. 2024

Discov Onc

View full text Add to dashboard Cite

Objective To evaluate the diagnostic value of 68Ga-prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) for intracapsular prostate cancer with a poor prognosis (PPC) and no extracapsular invasion or distant metastasis. Methods The PET/CT images and clinical data of 221 patients were retrospectively analyzed. These patients all had clear pathological results. The maximum standard uptake value (SUVmax) of the main lesions was measured at the postprocessing workstation and was tested for correlation with the pathological score. The diagnostic accuracy was calculated using the receiver operating characteristic (ROC) curve, and the best diagnostic threshold was calculated. The correlation between SUVmax and the International Society of Urological Pathology Grade Group (GG) was also analyzed. Results The pathological results of the 221 patients were 48 benign lesions and 173 malignant lesions, including 81 PPC. Low-, intermediate-, and high-risk prostate cancers made up 21.97% (38/173), 54.33% (94/173), and 23.70% (41/173) of the malignant lesions, respectively. SUVmax and GG were positively correlated (r = 0.54, P < 0.01). The best SUVmax thresholds for 68Ga-PSMA PET/CT for the diagnosis of intracapsular PC and PPC were 7.95 and 13.94, respectively; the specificities were 0.83 and 0.85, the negative predictive values were 0.55 and 0.87, and the areas under the ROC curves were 0.88 and 0.88, respectively. Conclusion 68Ga-PSMA PET/CT has high specificity and NPV in the diagnosis of intracapsular PPC, but the sensitivity for the diagnosis of intracapsular low-risk PC is low, which may cause some cases to be undetected.

show abstract

Section: Discussionmentioning

confidence: 99%