International summit on cutaneous antifungal therapy

Elewski, Boni E.; Hay, Roderick J.

doi:10.1016/0190-9622(95)91838-8

Cited by 21 publications

(15 citation statements)

References 40 publications

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“…In our study, tinea pedis (26%) was more frequent than previously reported (5–15%) in other industrial countries [6], [44]. This is an important finding because it is associated with other diseases, e.g.…”

Section: Discussionsupporting

confidence: 54%

High Prevalence of Skin Diseases and Need for Treatment in a Middle-Aged Population. A Northern Finland Birth Cohort 1966 Study

et al. 2014

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To determine the overall prevalence of skin diseases a whole-body skin examination was performed for 1,932 members (46-years of age) of the Northern Finland Birth Cohort (NFBC 1966), which is a comprehensive longitudinal research program (N = 12,058). A high prevalence of all skin diseases needing treatment was found (N = 1,158). Half of the cases of skin findings were evaluated to be serious enough to require diagnostic evaluation, treatment or follow-up either in a general health care, occupational health care or a secondary care setting. The remaining half were thought to be slight and self-treatment was advised. Males (70%) had more skin diseases needing treatment than females (52%) (P<0.001). The most common skin finding was a benign skin tumor, which was found in every cohort member. Skin infections (44%), eczemas (27%) and sebaceous gland diseases (27%) were the most common skin diseases in the cohort. Moreover, skin infections and eczemas were more commonly seen in the group with low education compared to those with high education (P<0.005). The results strengthen the postulate that skin diseases are common in an adult population.

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Section: Discussionsupporting

confidence: 54%

High Prevalence of Skin Diseases and Need for Treatment in a Middle-Aged Population. A Northern Finland Birth Cohort 1966 Study

et al. 2014

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“… 93 In view of ketoconazole’s side‐effects, some hesitation still exists in its use for the treatment of tinea versicolor, especially in children. 94–96 …”

Section: Therapymentioning

confidence: 99%

Tinea versicolor

1998

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“…These infections are frequent in tropical and subtropical areas. For example, S. dimidiatum accounts for 39% of dermatomycoses in Thai soldiers, whereas dermatophytes account for only 5% (6). In Gabon, S. dimidiatum was responsible for 34.2% of such cases, either alone or jointly with a dermatophyte or Candida albicans (14).…”

mentioning

confidence: 99%

Rapid Discrimination among Dermatophytes, Scytalidium spp., and Other Fungi with a PCR-Restriction Fragment Length Polymorphism Ribotyping Method

et al. 2001

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Dermatomycoses are very common infections caused mainly by dermatophytes. Scytalidiosis is a differential mycological diagnosis, especially in tropical and subtropical areas. Since a culture-based diagnosis takes 2 to 3 weeks, we set up a PCR-restriction fragment length polymorphism (RFLP) method for rapid discrimination of these fungi in clinical samples. The hypervariable V4 domain of the small ribosomal subunit 18S gene was chosen as the target for PCR. The corresponding sequences from 19 fungal species (9 dermatophytes, 2 Scytalidium species, 6 other filamentous fungi, and 2 yeasts) were obtained from databases or were determined in the laboratory. Sequences were aligned to design primers for dermatophyte-specific PCR and to identify digestion sites for RFLP analysis. The reliability of PCR-RFLP for the diagnosis of dermatomycosis was assessed on fungal cultures and on specimens from patients with suspected dermatomycosis. Two sets of primers preferentially amplified fungal DNA from dermatophytes (DH1L and DH1R) or from Scytalidium spp. (DH2L and DH1R) relative to DNA from bacteria, yeasts, some other filamentous fungi, and humans. Digestion of PCR products with EaeI or BamHI discriminated between dermatophytes and Scytalidium species, as shown with cultures of 31 different fungal species. When clinical samples were tested by PCR-RFLP, blindly to mycological findings, the results of the two methods agreed for 74 of 75 samples. Dermatophytes and Scytalidium spp. can thus be readily discriminated by PCR-RFLP within 24 h. This method can be applied to clinical samples and is suited to rapid etiologic diagnosis and treatment selection for patients with dermatomycosis.Dermatophytes, which belong to the genera Trichophyton, Microsporum, and Epidermophyton, are extremely widespread fungi that infect human skin, hair, and nails. They are responsible for most superficial fungal infections, causing 94.7% of cases of tinea pedis and 81.9% of cases of onychomycosis in the United States (13). Scytalidium hyalinum and Scytalidium dimidiatum are molds responsible for skin lesions and onychomycoses, which mimic those due to Trichophyton rubrum. These infections are frequent in tropical and subtropical areas. For example, S. dimidiatum accounts for 39% of dermatomycoses in Thai soldiers, whereas dermatophytes account for only 5% (6). In Gabon, S. dimidiatum was responsible for 34.2% of such cases, either alone or jointly with a dermatophyte or Candida albicans (14).Laboratory diagnosis of dermatomycosis is based on the demonstration of hyphae by direct microscopic examination of clinical samples, followed by species identification by culture. Microscopic examination is rapid, but it can be difficult to differentiate hyphae from dermatophytes or molds. Culture requires at least 2 to 3 weeks to obtain typical macroscopic and microscopic features for specific dermatophyte identification.In rare cases, identification is hindered by the absence of specific macroscopic and microscopic characteristics; subculture on specific media ...

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International summit on cutaneous antifungal therapy

Cited by 21 publications

References 40 publications

High Prevalence of Skin Diseases and Need for Treatment in a Middle-Aged Population. A Northern Finland Birth Cohort 1966 Study

High Prevalence of Skin Diseases and Need for Treatment in a Middle-Aged Population. A Northern Finland Birth Cohort 1966 Study

Tinea versicolor

Rapid Discrimination among Dermatophytes, Scytalidium spp., and Other Fungi with a PCR-Restriction Fragment Length Polymorphism Ribotyping Method

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