Both types of surfactant, given either prophylactically (in the delivery room within 15 min of birth) (Soll, Cochrane Database Syst Rev 2:CD000511, 2000a; Soll and Ozek, Cochrane Database Syst Rev 1: CD001079, 2010) or for treatment of RDS (Seger and Soll, Cochrane Database Syst Rev 2: CD007836, 2009; Soll, Cochrane Database Syst Rev 2: CD001149, 2000b), increased neonatal survival and reduced pulmonary air leaks such as pneumothorax and pulmonary interstitial emphysema.