International Terminology of Colposcopy: An Updated Report From the International Federation for Cervical Pathology and Colposcopy

Walker, Patrick; Dexeus, S; Palo, Giuseppe De; Barrasso, R; Campion, Michael J.; Girardi, Frank; Jakob, C; Roy, Marie-Christine

doi:10.1097/00006250-200301000-00032

Cited by 39 publications

(54 citation statements)

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“…Colposcopy was performed at each clinic according to standard operating procedures, using the international nomenclature. 28 Per protocol, all women with abnormal colposcopy were to receive at least one biopsy from the most severe area and a minimum of one biopsy from each quadrant of atypical transformation zone (TZ). For women with normal colposcopy (and not in the random control group), two biopsies were performed at 12 and 6 o'clock of TZ.…”

Section: Colposcopy and Biopsiesmentioning

confidence: 99%

Evaluation of oncogenic human papillomavirus RNA and DNA tests with liquid‐based cytology in primary cervical cancer screening: The FASE study

Monsonégo

Hudgens

Zerat³

et al. 2010

Intl Journal of Cancer

132

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The APTIMA V R HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture V R 2; HC2) and liquid-based cytology (LBC; using PreservCyt V R ThinPrep liquid Pap) in a screening setting (French APTIMA screening evaluation [FASE] study). Women (N 5 5,006) aged 20-65 were screened by gynecologists in 17 private practices in Paris, France. One cervical specimen was collected and tested with LBC, AHPV and HC2 assays. Women were referred to colposcopy if they were ASC-US1 in LBC or HPV positive in either HPV assay. To control for verification bias, a random group (14%) with normal LBC and dually HPV negative tests underwent colposcopy. Data from 4,429 women were analyzed. Sensitivity, specificity and predictive values were calculated for the three tests. AHPV and HC2 were highly sensitive for CIN21 (92.0% and 96.7%) and CIN31 (95.7% and 95.3%) detection and much more sensitive than LBC (69.1% for CIN21 and 73.3% for CIN31). Specificity of AHPV was higher than that of HC2, but similar to that of LBC (p < 0.001). Combining LBC with either HPV test slightly increased sensitivity but compromised specificity. AHPV assay is both specific and sensitive for the detection of high-grade precancerous lesions and may be considered as an option for routine cervical cancer screening for women over 20 years of age.Invasive cervical cancer (ICC) is the second most frequent female cancer worldwide, 1 with an estimation of 493,000 cases annually. ICC incidence and mortality rates have dramatically declined over the past five decades in developed countries, largely due to screening programs based on conventional cervical Papanicolaou (Pap) smears. 2,3 Conventional Pap smear screening, however, has limited sensitivity, positive predictive value (PPV) and reproducibility, which limits its use for primary screening. 3,4-7 Liquid-based cytology (LBC) has been shown to be more sensitive than conventional

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Section: Colposcopy and Biopsiesmentioning

confidence: 99%

Evaluation of oncogenic human papillomavirus RNA and DNA tests with liquid‐based cytology in primary cervical cancer screening: The FASE study

Monsonégo

Hudgens

Zerat³

et al. 2010

Intl Journal of Cancer

132

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“…As the primary organization of colposcopists and cervical cytologists, IFCPC recommended that this updated format be used for clinical diagnosis, treatment and research in cervical cancer. 10 The new transformation zone classification. One of the most important recommendations in the new IFCPC classification was to define three types of TZ.…”

Section: Colposcopymentioning

confidence: 99%

“…One of the most important recommendations in the new IFCPC classification was to define three types of TZ. 10,11 The system has three indices by which the TZ may be classified (Table 2). These are:…”

Section: Colposcopymentioning

confidence: 99%

“…The type 3 TZ has a high risk of Table 1 is reproduced from ref. [10] with permission of the American College of Obstetricians and Gynaecologists. *The characteristics of high-grade changes (dense acetowhite epithelium, coarse mosaic, coarse punctation, thick leukoplakia, atypical vessels); characteristics of low-grade changes are faint aceto-white epithelium, fine mosaic, fine punctuation, thin leukoplakia.…”

Section: Colposcopymentioning

confidence: 99%

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European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1

et al. 2008

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European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1The current paper presents the first part of Chapter 6 of the second edition of the European Guidelines for Quality Assurance in Cervical Cancer Screening. It provides guidance on how to manage women with abnormal cervical cytology. Throughout this article the Bethesda system is used for cervical cytology terminology, as the European guidelines have recommended that all systems should at least be translated into that terminology while cervical intraepithelial neoplasia (CIN) is used for histological biopsies (Cytopathology 2007; 18:213-9). A woman with a high-grade cytological lesion, a repeated low-grade lesion or with an equivocal cytology result and a positive human papillomavirus (HPV) test should be referred for colposcopy. The role of the colposcopist is to identify the source of the abnormal cells and to make an informed decision as to whether or not any treatment is required. If a patient requires treatment the colposcopist will decide which is the most appropriate method of treatment for each individual woman. The colposcopist should also organize appropriate follow-up for each woman seen. Reflex testing for high-risk HPV types of women with atypical squamous cells (ASC) of undetermined significance with referral for colposcopy of women who test positive is a first option. Repeat cytology is a second possibility. Direct referral to a gynaecologist should be restricted to special circumstances. Follow-up of low-grade squamous intraepithelial lesion is more difficult because currently there is no evidence to support any method of management as being optimal; repeat cytology and colposcopy are options, but HPV testing is not sufficiently selective, unless for older women. Women with high-grade squamous intraepithelial lesion (HSIL) or atypical squamous cells, cannot exclude HSIL (ASC-H) should be referred without triage. Women with glandular lesions require particular attention. In a subsequent issue of Cytopathology, the second part of Chapter 6 will be presented, with recommendations for management and treatment of histologically confirmed intraepithelial neoplasia and guidance for follow-up of special cases such as women who are pregnant, postmenopausal or immunocompromised.

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“…The criteria for vascular changes described in colposcopic literature for the selection of biopsy site has been described as follows [18][19][20][21].…”

Section: Blood Vascular Patternmentioning

confidence: 99%

Colposcopy - A Novel Diagnostic Technique for Oral Mucosal Lesions

Kumar

Prakash

et al. 2014

JCDR

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International Terminology of Colposcopy: An Updated Report From the International Federation for Cervical Pathology and Colposcopy

Cited by 39 publications

References 1 publication

Evaluation of oncogenic human papillomavirus RNA and DNA tests with liquid‐based cytology in primary cervical cancer screening: The FASE study

Evaluation of oncogenic human papillomavirus RNA and DNA tests with liquid‐based cytology in primary cervical cancer screening: The FASE study

European guidelines for quality assurance in cervical cancer screening: recommendations for clinical management of abnormal cervical cytology, part 1

Colposcopy - A Novel Diagnostic Technique for Oral Mucosal Lesions

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