International validation of the out-of-hospital cardiac arrest score in the United States*

Hunziker, Sabina; Bivens, Matthew J.; Cocchi, Michael N.; Miller, Joseph C.; Salciccioli, Justin D.; Howell, Michael D.; Donnino, Michael W.

doi:10.1097/ccm.0b013e318218a05b

Cited by 38 publications

(33 citation statements)

References 18 publications

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“…The adequacy of the fitted model was performed by goodness-of-fit tests used the Hosmer–Lemeshow test for binary response data in which a P -value >0.1 indicates a good fit. 36 Before reaching definitive conclusions from the results of this method, the jack-knife method (a performance evaluation method in which a measured value predicted from the n -1 observations, removing the own predicted observation: leave-one-out cross validation) was used to quantify the model's internal validity. 37 Finally, results for independent variables were typically reported as odds ratios with 95% confidence intervals.…”

Section: Methodsmentioning

confidence: 99%

Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis

et al. 2016

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Although evidence for mitochondrial dysfunction in the pathogenesis of bipolar disorder (BD) has been reported, the precise biological basis remains unknown, hampering the search for novel biomarkers. In this study, we performed metabolomics of cerebrospinal fluid (CSF) from male BD patients (n=54) and age-matched male healthy controls (n=40). Subsequently, post-mortem brain analyses, genetic analyses, metabolomics of CSF samples from rats treated with lithium or valproic acid were also performed. After multivariate logistic regression, isocitric acid (isocitrate) levels were significantly higher in the CSF from BD patients than healthy controls. Furthermore, gene expression of two subtypes (IDH3A and IDH3B) of isocitrate dehydrogenase (IDH) in the dorsolateral prefrontal cortex from BD patients was significantly lower than that of controls, although the expression of other genes including, aconitase (ACO1, ACO2), IDH1, IDH2 and IDH3G, were not altered. Moreover, protein expression of IDH3A in the cerebellum from BD patients was higher than that of controls. Genetic analyses showed that IDH genes (IDH1, IDH2, IDH3A, IDH3B) and ACO genes (ACO1, ACO2) were not associated with BD. Chronic (4 weeks) treatment with lithium or valproic acid in rats did not alter CSF levels of isocitrate, and mRNA levels of Idh3a, Idh3b, Aco1 and Aco2 genes in the rat brain. These findings suggest that abnormality in the metabolism of isocitrate by IDH3A in the mitochondria plays a key role in the pathogenesis of BD, supporting the mitochondrial dysfunction hypothesis of BD. Therefore, IDH3 in the citric acid cycle could potentially be a novel therapeutic target for BD.

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Section: Methodsmentioning

confidence: 99%

Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis

et al. 2016

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“…12 The OHCA score is a prognostic score derived specifically to predict poor neurologic outcome in OHCA populations and we have validated its reliability as a predictive tool in an external population. 13 OHCA scores were treated as a continuous variable for multivariable adjustments. All data were collected locally, removed of any personal identifying information and entered into a secure electronic database that was shared across participating sites.…”

Section: Methodsmentioning

confidence: 99%

Continuous neuromuscular blockade is associated with decreased mortality in post-cardiac arrest patients

et al. 2013

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Aim Neuromuscular blockade may improve outcome in patients with acute respiratory distress syndrome. In post-cardiac arrest patients receiving therapeutic hypothermia, neuromuscular blockade is often used to prevent shivering. Our objective was to determine whether neuromuscular blockade is associated with improved outcomes after out-of-hospital cardiac arrest. Methods A post-hoc analysis of a prospective observational study of comatose adult (> 18 years) out-of-hospital cardiac arrest at 4 tertiary cardiac arrest centers. The primary exposure of interest was neuromuscular blockade for 24 hours following return of spontaneous circulation and primary outcomes were in-hospital survival and neurologically intact survival. Secondary outcomes were evolution of oxygenation (PaO2:FiO2), and change in lactate. We tested the primary outcomes of in-hospital survival and neurologically intact survival with multivariable logistic regression. Secondary outcomes were tested with multivariable linear mixed-models. Results A total of 111 patients were analyzed. In patients with 24 hours of sustained neuromuscular blockade, the crude survival rate was 14/18 (78%) compared to 38/93 (41%) in patients without sustained neuromuscular blockade (p = 0.004). After multivariable adjustment, neuromuscular blockade was associated with survival (adjusted OR: 7.23, 95% CI: 1.56 –33.38). There was a trend toward improved functional outcome with neuromuscular blockade (50% vs. 28%; p = 0.07). Sustained neuromuscular blockade was associated with improved lactate clearance (adjusted p = 0.01). Conclusions We found that early neuromuscular blockade for a 24-hour period is associated with an increased probability of survival. Secondarily, we found that early, sustained neuromuscular blockade is associated with improved lactate clearance.

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“…Multivariate (stepwise selection forward method) logistic regression analyses were performed to evaluate the association between immunophenotypic data (as a continuous variable) and AL-MDS. Internal validation of the logistic regression models was performed using the Hosmer-Lemeshow goodness-of-fit test, in which a P value greater than 0.1 indicates a good fit [23], and the performance was evaluated by the jackknife method (a performance evaluation method in which a measured value predicted from the n-1 observations removing the own predicted observation) [24]. Statistical analysis was performed using SAS version 9.1 (SAS Institute, Cary, NC).…”

Section: Discussionmentioning

confidence: 99%

Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: A multicenter validation study

et al. 2012

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International validation of the out-of-hospital cardiac arrest score in the United States*

Cited by 38 publications

References 18 publications

Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis

Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis

Continuous neuromuscular blockade is associated with decreased mortality in post-cardiac arrest patients

Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: A multicenter validation study

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