International variation

Parkin, Donald Maxwell

doi:10.1038/sj.onc.1207726

Cited by 541 publications

(421 citation statements)

References 53 publications

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“…Incidence rates for gastric cancer have declined worldwide (Parkin, 1993;2004;Bertuccio et al, 2009;Jemal et al, 2009). However, gastric cancer is the fourth most commonly diagnosed cancer (Ferlay et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Perineural Invasion Independent Prognostic Factors in Patients with Gastric Cancer Undergoing Curative Resection

Selçukbiricik

Tural²,

Büyükünal³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

Perineural Invasion Independent Prognostic Factors in Patients with Gastric Cancer Undergoing Curative Resection

Selçukbiricik

Tural²,

Büyükünal³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Gastric cancer is the fourth most frequent type of cancer in the world with a prevalence that varies greatly depending on geographic location (Parkin, 2004). In western countries, this cancer has a decreasing incidence but still accounts for significant overall mortality (Dicken et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…In EGC, prognosis is favorable, after gastrectomy and lymph node dissection, accounting for 5-and 10-year survival rates of 90 and 85-90%, respectively, compared with 20-30% in AGC (Lawrence and Shiu, 1991;Dicken et al, 2005). Therefore, great attention has been directed to early detection in countries where gastric carcinoma is prevalent, such as Japan and Korea (Henderson, 1990;Parkin, 2004).…”

Section: Introductionmentioning

confidence: 99%

Gene expression analysis of early and advanced gastric cancers

et al. 2007

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Gastric carcinoma is one of the major causes of cancer mortality worldwide. Early detection results in excellent prognosis for patients with early cancer (EGC), whereas the prognosis of advanced cancer (AGC) patients remains poor. It is not clear whether EGC and AGC are molecularly distinct, and whether they represent progressive stages of the same tumor or different entities ab initio. Gene expression profiles of EGC and AGC were determined by Affymetrix technology and quantitative polymerase chain reaction. Representative regulated genes were further analysed by in situ hybridization (ISH) on tissue microarrays. Expression analysis allowed the identification of a signature that differentiates AGC from EGC. In addition, comparison with normal gastric mucosa indicated that the majority of alterations associated with EGC are retained in AGC, and that further expression changes mark the transition from EGC to AGC. Finally, ISH analysis showed that representative genes, differentially expressed in the invasive areas of EGC and AGC, are not differentially expressed in the non-invasive areas of the same tumors. Our data are more directly compatible with a progression model of gastric carcinogenesis, whereby EGC and AGC may represent different molecular stages of the same tumor. Finally, the identification of an AGC-specific signature might help devising novel therapeutic strategies for advanced gastric cancer.

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“…In spite of the strong downward mortality rates worldwide, stomach cancer is the second most important cause of death from cancer worldwide (Parkin, 2004;Jemal et al, 2011). In Serbia, with 1313 deaths and 5.4% in total number of deaths from malignant tumors in 2008, stomach cancer takes the fourth place.…”

Section: Discussionmentioning

confidence: 99%

“…Factors leading to the decrease in stomach cancer mortality include broader availability of fresh fruit and vegetables, less salt and conserved food in the diet, better food conservation including refrigeration, decreased incidence of chronic infections with Helicobacter pylori resulting from improved hygiene and use of antibiotics, and introduction of the screening program (Levi et al, 2004;Parkin, 2004;Lee et al, 2006;Yang, 2006). Evidence linking Helicobacter pylori infection with stomach cancer risk contributed to the 1994 International Agency for Research on Cancer's classification of the bacterium as carcinogenic to humans (IARC, 1994).…”

Section: Discussionmentioning

confidence: 99%