In today's corporate landscape, optimizing performance has emerged as a formidable challenge for organizations, often hindered by formidable barriers and psychological factors. This study explores the role of anxiety, stress, and depression in attaining performance among Egyptian construction site workers. The quantitative analysis utilizes cross-sectional data collected from workers working at different construction sites in Egypt. The study concludes with findings from 298 valid cases. Leveraging the structural equation model (SEM) in a path analysis, the results unveil a stark negative impact of anxiety (p-value = 0.199), stress (p-value = 0.115), and depression (p-value = 0.209) on overall performance. Furthermore, it underscores the noteworthy predictive power of anxiety (p-value = 0.000) and stress (p-value = 0.000) on depression. These findings carry implications for both policy-makers and psychologists, offering valuable guidance for the formulation of strategies aimed at reducing anxiety, stress, and depression to catalyze enhanced performance. Besides, this study contributes a meaningful empirical perspective to the broader psychological and medical literature drawn from the unique context of construction site workers in a developing nation.