Interobserver agreement in detection of “white globe appearance” and the ability of educational lectures to improve the diagnosis of gastric lesions

Omura, Hitoshi; Yoshida, Naohiro; Hayashi, Tomoyuki; Miwa, Kazuhiro; Takatori, Hajime; Tsuji, Hirokazu; Inamura, Katsuhisa; Shirota, Yukihiro; Aoyagi, Haruhiko; Masunaga, Takaharu; Kawakami, Kazuyoshi; Kuroda, Hiroshi; Kaneko, Shuichi; Doyama, Hisashi

doi:10.1007/s10120-016-0676-3

Cited by 11 publications

(12 citation statements)

References 20 publications

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“…Some previous studies [9][10][11] have reported that WGA is a novel and reliable marker of gastric cancer under ME-NBI. One of the pathologic features of WGA in EGC is IND, which has been shown to be a histological marker of cancer and present at high levels in intraepithelial neoplasia and invasive carcinoma [15].…”

Section: Discussionmentioning

confidence: 97%

“…▶ In addition, Doyama et al [9][10][11] reported that the histological examination of WGA in cancerous lesions was IND, defined as eosinophilic substances (necrotic epithelial debris) contained within a large gland. It was not difficult to understand that the occurrence of tumors may begin in a specific gland.…”

Section: Discussionmentioning

confidence: 99%

“…Several previous studies [9][10][11] have reported a new endoscopic marker termed white globe appearance (WGA), a small (< 1 mm) white globular lesion located underneath the epithelium, as demonstrated by ME-NBI, that can predict specific histopathological findings of EGC.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, another prospective study by Yoshida et al [10] showed that the prevalence of WGA was significantly higher in gastric cancer than in non-cancerous lesions, including gastritis mucosa. They observed that a brief educational lecture about WGA could improve the diagnosis of gastric cancer [11]. Therefore, they considered that WGA had high specificity for the differentiation of EGC and non-cancerous lesions.…”

Section: Introductionmentioning

confidence: 99%

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A new exploration of white globe appearance (WGA) in ulcerative lesions

et al. 2020

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Aim White globe appearance (WGA), a small white lesion with a globular shape that can be clearly visualized by magnifying endoscopy with narrow-band imaging (ME-NBI), was reported to be a reliable marker of early gastric cancer (EGC). However, we found that this endoscopic presentation could also be seen in non-cancerous tissues, especially in ulcerative lesions. This study aimed to further investigate the diagnostic value of WGA in differentiating non-cancerous lesions from EGC in ulcer-type cases. Materials and Methods We retrospectively reviewed 54 cases of EGC and 155 cases of non-cancerous lesions in this study, all of which had endoscopic imaging data of ME-NBI scanning and pathological data of biopsy or resected specimens. The correlation of the prevalence of WGA and ulcerative lesions, as well as the characteristics of WGA between the 2 groups were analyzed in this study. Results WGA was more common in ulcerative lesions (27.6 %, 21/76) than in non-ulcerative lesions (3.8 %, 5/133) (p < 0.001) in our study. In the ulcerative cases, no significant difference in prevalence of WGA was observed between EGC and non-cancerous lesions (p = 0.532). Compared with WGA in EGC, WGA in non-cancerous lesions tended to show the characteristic of tree-branch-like vessels on globular shape (p < 0.001). Conclusions WGA is more likely to occur in ulcerative lesions, and the presence of WGA alone cannot distinguish EGC from non-cancerous lesions in ulcer-type cases. In WGA-positive tissue, tree-branch-like vessels of globular shape may provide a certain clinical value in diagnosis of non-cancerous lesions or EGC.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A new exploration of white globe appearance (WGA) in ulcerative lesions

et al. 2020

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“…White globe appearance has been reported to be characterized by a small (<1 mm) white lesion with a globular shape and microvessels overlying the white substance, reflecting the white substance existing underneath the gastric epithelium and subepithelial microvessels [ 1 – 3 ]. Detection of white globe appearance during esophagogastroduodenoscopy is clinically significant because this endoscopic feature is reportedly found within the margin of the cancerous gastric epithelium.…”

Section: Introductionmentioning

confidence: 99%

Two Cases of White Globe Appearance in Autoimmune Atrophic Gastritis

Iwamuro

Tanaka

Kanzaki

et al. 2018

Case Reports in Gastrointestinal Medicine

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In this report, we described two patients with white globe appearance in autoimmune atrophic gastritis. Endoscopy revealed multiple white substances in the stomach in both cases. Biopsied specimens from the lesions contained dilated glands and showed a decrease in parietal cells. Intraglandular necrotic debris and carcinoma were absent. These results confirmed that white globe appearance can be observed in autoimmune atrophic gastritis. Moreover, microscopic features for white globe appearance observed in these cases were different from those reported previously in gastric cancer lesions and were similar to those observed for noncancerous stomach.

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