Interobserver and Intraobserver Reliability of Detecting Age-related Macular Degeneration Using a Nonmydriatic Digital Camera

Tien, V. Le; Streho, M.; d’Athis, Philippe; Taillandier-Heriche, E.; Paillaud, Éléna; Mahiddine, H.; Coscas, G.; Lejonc, J. L.; Soubrane, G.; Souied, Eric H.

doi:10.1016/j.ajo.2008.05.031

Cited by 25 publications

(18 citation statements)

References 36 publications

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“…The rates for early and late AMD were similar to those in previous epidemiological studies [5,6,7,8]. Grade 4 was found in only 0.4% of the cases in our study because 3.3% of the initial 1,022 patients were excluded due to their prior history of AMD.…”

Section: Discussionsupporting

confidence: 90%

“…Large-scale screening may permit the development of preventive information and treatment for patients who are at risk of visual loss. Previous studies had shown the clinical interest in detecting earlier AMD on fundus photographs [6,7,8,9,10,11,12,13,14,15]. The 5-year risk of late AMD (grade 4) after diagnosis of early AMD (grade 2 or 3) by fundus photography had been demonstrated in the AREDS (Age-Related Eye Disease Study) Report No.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, an efficient method of large-scale screening with decentralized photographic units is needed for detecting patients who are at risk of visual loss. Color fundus photographs are used to document the presence and to grade the severity of AMD in clinical practice, in epidemiological studies and also in the context of screening [2,3,4,5,6,7,8,9]. To our knowledge, it is the first time that a nonmydriatic color fundus camera was used as an AMD screening tool in a decentralized nonophthalmological team, with photographs taken by a nonophthalmologist and analyzed for its diagnostic rentability.…”

Section: Introductionmentioning

confidence: 99%

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Age-Related Macular Degeneration Screening Using a Nonmydriatic Digital Color Fundus Camera and Telemedicine

et al. 2013

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Purpose: To investigate the use of a nonmydriatic digital color fundus camera and telemedicine as screening tools for age-related macular degeneration (AMD). Methods: Nonmydriatic color fundus photography was performed on patients consulting health examination centers and transmitted by telemedicine to an ophthalmology department. Rates for different grades of AMD were calculated and also statistically related to the presence or absence of risk factors. Results: Among the 1,022 patients screened, a total of 1,363 color fundus photographs were interpreted, with 80% gradable images, allowing a diagnosis of AMD in 178 photographs. Among all the gradable images, 83.7% had no AMD (grade 0). The rates of AMD at grades 1, 2, 3 and 4 were 8%, 5.6%, 2.3% and 0.4%, respectively. A statistical odds ratio was found between the presence of AMD on fundus photographs and age, familial history of AMD or prior cataract surgery. Conclusions: Nonmydriatic color fundus photography and telemedicine succeeded in screening for AMD.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Age-Related Macular Degeneration Screening Using a Nonmydriatic Digital Color Fundus Camera and Telemedicine

et al. 2013

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“…Associations between each stage of AMD and each type of early AMD characteristics and RPD were estimated using logistic generalized estimating equations (GEE) models taking into account data from both eyes and their intraindividual correlations. 23 The associations are presented as odds ratios (ORs) and 95% confidence intervals (CIs). Eyes without RPD were the reference in all models.…”

Section: Discussionmentioning

confidence: 99%

“…Such high-resolution digital photographs have shown comparable grading qualities to those of previous film-based photographs. 23 Color and contrast were adjusted if needed to obtain better images when interpreting.…”

Section: Eye Examinationmentioning

confidence: 99%

Multimodal Imaging of Reticular Pseudodrusen in a Population-Based Setting: The Alienor Study

Chan

Cougnard‐Grégoire

Delyfer

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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57:3058-3065. DOI:10.1167/ iovs.16-19487 PURPOSE. To document reticular pseudodrusen (RPD) using multimodal imaging in French elderly subjects. METHODS.A total of 494 subjects (970 eyes) aged 77 years or more, from the Alienor study, were examined in 2011 and 2012. Reticular pseudodrusen were defined as definite if they were present with at least two imaging methods among color retinal photographs, macular cube (208 3 158) of spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and infrared reflectance (IR). The Youden index was calculated as specificity þ sensitivity À 1.RESULTS. The prevalence of definite RPD was 13.4% and was higher among women (15.6%) than men (10.2%). It increased with age and reached almost 50% in subjects over 85 years. Infrared reflectance was the most sensitive technique (100%) and color fundus photography the least sensitive (34.5% at left eyes and 48.1% at right eyes). The best Youden index was obtained with IR (0.96 at both eyes) followed by SD-OCT (0.87 at right eye and 0.78 at left eye). Reticular pseudodrusen were present in 4.6% of eyes without AMD, 13.0% with early AMD1, 62.6% with early AMD2, 34.6% with atrophic AMD, and 8.1% with neovascular AMD. Reticular pseudodrusen were significantly associated with central and pericentral intermediate soft drusen (odds ratio [OR]: 2.14; 95% confidence interval [CI] ¼ 1.11-4.14 and OR: 1.49; 95% CI ¼ 1.16-1.90, respectively) and central large soft drusen (OR: 1.67; 95% CI ¼ 1.16-2.42).CONCLUSIONS. Using multimodal imaging, the prevalence of RPD appears higher than previously reported in studies based on retinal photography only. Reticular pseudodrusen frequently accompany other signs of AMD. Infrared reflectance and SD-OCT appear to be particularly relevant methods to diagnose RPD.

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Characteristics and outcome of immune thrombocytopenia in elderly: Results from a single center case‐controlled study

et al. 2011

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The management of ITP in elderly raises several questions that have not been fully addressed in the literature. To assess the impact of ITP in elderly, a case-control study was performed. The main characteristics at onset and the outcome of ITP in 55 patients aged of 70 years and above (cases) were compared with those of 97 younger adults (controls) seen at the same tertiary referral institution. The mean age at diagnosis was respectively 77.8 ± 6.1 years (cases) and 40.3 ± 14.9 years (controls). While the median platelet count at time of diagnosis was not significantly different in cases and controls (6310 9 /L, range: 2-26 versus 12310 9 /L: 5-21.5), bleeding symptoms were more frequent in cases (82%) than in the controls (68%, p50.07), and the median bleeding score was significantly higher in elderly (p50.001). The rate of treatmentrelated adverse events was more than twofold higher in elderly patients and the mean cumulative duration of hospital stay for ITP during the follow-up period was much longer when compared to the controls (p<0.0001). Three ITP-related deaths (5.4%) including 1 from intracranial hemorrhage occurred in the cases but none in the controls. In conclusion, this study confirms that at equivalent platelet count, ITP has a greater impact in elderly. Am. J. Hematol. 86:980-984, 2011. V

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Interobserver and Intraobserver Reliability of Detecting Age-related Macular Degeneration Using a Nonmydriatic Digital Camera

Cited by 25 publications

References 36 publications

Age-Related Macular Degeneration Screening Using a Nonmydriatic Digital Color Fundus Camera and Telemedicine

Age-Related Macular Degeneration Screening Using a Nonmydriatic Digital Color Fundus Camera and Telemedicine

Multimodal Imaging of Reticular Pseudodrusen in a Population-Based Setting: The Alienor Study

Characteristics and outcome of immune thrombocytopenia in elderly: Results from a single center case‐controlled study

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