Interobserver variability of ultrasound parameters in portal hypertension

Sales, Danilo Moulin; Santos, José Eduardo Mourão; Leão, Alberto Ribeiro de Souza; Costa, Juliana Dantas da; Takemoto, Kenji; Capobianco, Júlia; Bezerra, Alexandre Sérgio de Araújo; D'Ippólito, Giuseppe

doi:10.1590/s0074-02762010000400010

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…A criticism of PSR is the subjectivity in measurement of spleen bipolar diameter, but studies have shown the latter to be a reliable parameter with excellent reproducibility as measured by both kappa statistic and intra-class correlation coefficient. 42,43 LSM by transient elastography was the second most accurate diagnostic test in this study and has validated diagnostic accuracy for the detection of cirrhosis across mixed aetiologies. 44 Therefore, the advantage is that one test could be used to diagnose cirrhosis and also stratify for OV; however, the precise thresholds for diagnosing OV are yet to be defined.…”

Section: Implications For Clinical Practice and Areas For Future Resementioning

confidence: 59%

Non‐invasive tests for the detection of oesophageal varices in compensated cirrhosis: systematic review and meta‐analysis

et al. 2018

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Section: Implications For Clinical Practice and Areas For Future Resementioning

confidence: 59%

Non‐invasive tests for the detection of oesophageal varices in compensated cirrhosis: systematic review and meta‐analysis

et al. 2018

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“…The prediction models used in this study can be calculated easily. The inter-observer variability of the spleen diameter and splenic vein diameter is low, which makes the prediction models reproducible (Sebastianes et al, 2010;Gunes and Akturk, 2018). The measurement of lymphocyte ratio by routine blood tests is easy, highly reproducible, and low-cost (Feng et al, 2018;Chisthi, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…In the last two decades, much effort has been devoted to finding non-invasive methods of predicting the presence of EVs and HREVs. Currently, non-invasive predictive parameters are predominantly imaging/ultrasonographic and laboratory parameters, including spleen diameter, spleen/liver stiffness, portal/splenic vein diameter, platelet count, platelet count to spleen diameter ratio, Fibrosis-4 score (FIB-4), aspartate aminotransferase to platelet ratio index (APRI), and aspartate aminotransferase to alanine aminotransferase ratio (AAR) ( Giannini et al, 2003 ; Giannini et al, 2006 ; Hong et al, 2009 ; Kim et al, 2010 ; Colecchia et al, 2012 ; Berzigotti et al, 2013 ; Montasser et al, 2014 ; Morishita et al, 2014 ; Rockey et al, 2016 ). A few studies have reported the non-invasive prediction of EVB ( Kothari et al, 2019 ; Wan et al, 2021 ) and large EVs ( Sharma and Aggarwal, 2007 ; Lijing et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Prediction Models for Esophageal Varices and Red Signs in Patients With Hepatitis B Virus-Related Liver Cirrhosis

Liang

Liu

et al. 2022

Front. Mol. Biosci.

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Background: Red signs are closely related to esophageal variceal bleeding, and, despite improvements in therapy, the mortality rate remains high. We aimed to identify non-invasive predictors of esophageal varices and red signs in patients with hepatitis B virus-related liver cirrhosis.Methods: This retrospective study included 356 patients with hepatitis B virus-related liver cirrhosis after applying inclusion and exclusion criteria among 661 patients. All patients underwent endoscopy, ultrasonography, laboratory examinations, and computed tomography/magnetic resonance imaging. Univariate and multivariate logistic regression analysis were performed, and prediction models for esophageal varices and red signs were constructed.Results: Multivariate analysis revealed that spleen diameter, splenic vein diameter, and lymphocyte ratio were independent risk factors for esophageal varices and red signs. On this basis, we proposed two models: i) a spleen diameter-splenic vein diameter-lymphocyte ratio-esophageal varices prediction model (SSL-EV model); and ii) a spleen diameter-splenic vein diameter-lymphocyte ratio-red sign prediction model (SSL-RS model). The areas under the receiver operating characteristic curve for the two prediction models were 0.843 and 0.783, respectively. With a cutoff value of 1.55, the first prediction model had 81.3% sensitivity and 76.1% specificity for esophageal varices prediction. With a cutoff value of −0.20, the second prediction model had 72.1% sensitivity and 70.7% specificity for the prediction of red signs.Conclusions: We proposed a new statistical model, the spleen diameter-splenic vein diameter-lymphocyte ratio-red sign prediction model (SSL-RS model), to predict the presence of red signs non-invasively. Combined with the spleen diameter-splenic vein diameter-lymphocyte ratio-esophageal varices prediction model (SSL-EV model), these non-invasive prediction models will be helpful in guiding clinical decision-making and preventing the occurrence of esophageal variceal bleeding.

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“…Despite the wide utilization of US, some limitations -among others, the one related to reproducibility -, have been attributed to the method (8) . However, most recently it was demonstrated that US presents a high agreement in the evaluation of patients with portal hypertension (11) , reinforcing its utility amongst SM patients.…”

Section: Editorialmentioning

confidence: 93%