2018
DOI: 10.1101/367813
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Interocular Symmetry and Repeatability of Foveal Outer Nuclear Layer Thickness in Congenital Achromatopsia

Abstract: Cone Photoreceptors 18 19Precise: (21/35 Submitted separately as "Highlights" file) We examined the intraobserver 20 repeatability and interocular symmetry of foveal outer nuclear layer (ONL) thickness 21 measurements in patients with congenital achromatopsia. . CC-BY-NC 4.0 International license It is made available under a was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.11… Show more

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Cited by 2 publications
(10 citation statements)
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“…3B). Previously reported mean ± SD from unaffected controls for ONL thickness is 110.6 ± 15.7 μm, with an n = 38 (mean age ± SD; 28.8 ± 10.9 years);46 these values are significantly higher than our reported values for CNGA3 -ACHM ( P < 0.0001, t = 8.37, df = 74). ONL thickness at the fovea was measured with standard OCT.…”
Section: Resultscontrasting
confidence: 70%
“…3B). Previously reported mean ± SD from unaffected controls for ONL thickness is 110.6 ± 15.7 μm, with an n = 38 (mean age ± SD; 28.8 ± 10.9 years);46 these values are significantly higher than our reported values for CNGA3 -ACHM ( P < 0.0001, t = 8.37, df = 74). ONL thickness at the fovea was measured with standard OCT.…”
Section: Resultscontrasting
confidence: 70%
“…Foveal ONL thickness was highly variable in the seven cases studied, ranging from 39.22 to 174.04 μm, and the mean ± SD foveal ONL thickness for ATF6 -ACHM was 95.23 ± 41.88 μm. As shown in Figure 2, this was slightly lower than previously reported values for controls (110.60 ± 15.67 μm) 24. However, due to the small number of subjects with ATF6- ACHM and the larger range in their ONL thickness, this was not significant ( P = 0.3215, Dunn's multiple comparisons test).…”
Section: Resultscontrasting
confidence: 53%
“…In addition, only grade 3 and grade 4 EZ disruption was observed in direct contrast to CNGA3 - and CNGB3 -ACHM, in which all five EZ grades were observed 20,21,47. In previous work, 2% to 15% of subjects with CNGA3- and CNGB3 -ACHM had grade 3 EZ disruption and 24% to 31% had grade 4 20,21,24. Further disorganization was observed at the fovea including hyperreflectivity of the ONL (MM_0043, MM_0044) and apparent thickening of the ELM (MM_0152, JC_11438).…”
Section: Discussionmentioning
confidence: 71%
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