Interpenetrated polymer networks of poly(β-cyclodextrin) and polyvinylpyrrolidone with synergistic and selective sorption capacities

Abstract

Interpenetrating polymer network (IPN) hydrogels were synthesised using β-cyclodextrin (β-CD) and N-vynil-2-pyrrolidone (NVP) crosslinked with epichlorohydrin and divinylbenzene, respectively, and prepared by four different procedures: simultaneous, sequential, hybrid and a novel one named hybrid-sequential. The IPNs prepared have been characterised by infrared spectroscopy and thermal analysis. The equilibrium swelling in water and the sorption of model substances into the IPNs have also been studied. The model sorbates (1-naphthol, 2-acetylnaphthalene and tannic acid) were selected according to the affinities towards each one of the two constituent polymers. Our studies reveal that these IPNs can be applied for the sorption of substances that can interact with the network by two mechanisms, i.e. inclusion within cyclodextrin cavities and/or via specific interactions with the functional groups present. Besides, due to the complementary character of their constituent polymers, these networks could also serve to retain two substances of different nature such as cetirizine and pseudoephedrine.

Formation of Hydrophobic–Hydrophilic Associates in the N-Vinylpyrrolidone and Vinyl Propyl Ether Copolymer Aqueous Solutions

“…Stimulus-sensitive hydrogels, manifesting a capacity for dynamic phase transitions, represent a propitious platform for the advancement of extraction technologies, including the selective isolation of diverse low-molecular-weight substances from solution matrices [13,14]. Furthermore, the reversible character inherent in these phase transitions, characterized by gel collapse, facilitates cyclic enrichment or depletion of the solution [15][16][17].…”

Polymeric Hydrogels and Nanogels: Classification, Development and Pharmaceutical Applications

“…Chemical stimuli are pH, ionic strength, solvent composition, and molecular species. Biochemical stimuli include antigens, ligands, and enzymes [38].…”

History of cyclodextrin-based polymers in food and pharmacy: a review

“…Another semi-interpenetrated network was prepared by the radical polymerisation and crosslinking of N-isopropylacrylamide in the presence of β-cyclodextrin-grafted polyethylenimine (Zhang et al 2008). Interpenetrated networks can also be used to develop new selective and synergistic sorption capacities for specific purposes such as a combined drug release (Fujiyoshi et al 2019).…”