Interpenetrating Polymer Networks polysaccharide hydrogels for drug delivery and tissue engineering

Matricardi, Pietro; Meo, Chiara Di; Coviello, Tommasina; Hennink, Wim E.; Alhaique, Franco

doi:10.1016/j.addr.2013.04.002

Cited by 498 publications

(279 citation statements)

References 109 publications

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“…Hydrogels have received a considerable attention for use in tissue engineering scaffolds (with gelatin methacrylamide/PEG [72], silk fibroin/poly(vinyl alcohol) [73], silk fibroin/gelatin [74] or others [75]), cartilage tissue engineering (with poly (ethylene glycol)/agarose [76]), vascular tissue engineering (dextran/gelatin [77]). Mechanically enhanced properties (e.g., Young's moduli) rivaling those of natural load-bearing tissues was found in a poly (acrylic acid)/end-linked poly (ethylene glycol) crosslinked material [78].…”

Section: Examples Of Final Properties For Photochemically Produced Ipnsmentioning

confidence: 99%

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

Fouassier

Lalevée

2014

Polymers

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Abstract:In this paper, we propose to review the ways to produce, through photopolymerization, interpenetrating polymer networks (IPN) based, e.g., on acrylate/epoxide or acrylate/vinylether blends and to outline the recent developments that allows a one-step procedure (concomitant radical/cationic polymerization), under air or in laminate, under various irradiation conditions (UV/visible/near IR; high/low intensity sources; monochromatic/polychromatic sources; household lamps/laser diodes/Light Emitting Diodes (LEDs)). The paper illustrates the encountered mechanisms and the polymerization profiles. A short survey on the available monomer systems and some brief examples of the attained final properties of the IPNs is also provided.

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Section: Examples Of Final Properties For Photochemically Produced Ipnsmentioning

confidence: 99%

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

Fouassier

Lalevée

2014

Polymers

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“…Baik material alami maupun sintetik telah banyak digunakan untuk mensintesis hidrogel (Dragan et al, 2012;Matricardi et al, 2013).…”

Section: Pendahuluanunclassified

Sintesis dan Karakterisasi Hidrogel Superabsorben Kitosan Poli(N-Vinilkaprolaktam) (Pnvcl) Dengan Metode Full IPN (Interpenetrating Polymer Network)

Wivanius

Budianto

2015

Pharm Sci Res

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AbstrakMaterial polimer untuk menyusun hidrogel harus dapat mengembang (swell) dan mempertahankan fraksi air pada strukturnya, namun tidak larut dalam air. Polimer alami memiliki gugus fungsi yang dapat menjadi pusat aktif reaksi dimana dapat dilakukan modifikasi untuk menghasilkan suatu polimer dengan karakteristik yang lebih baik. Kitosan merupakan polimer alami yang memiliki kekuatan struktur yang kurang dibandingkan kemampuan mengembang. Sintesis hidrogel kitosan dengan metode full interpenetrating polymer network (IPN) dapat meningkatkan kekuatan struktur melalui ikat silang. Tahap pertama adalah sintesis jaringan polimer kitosan terikat silang asetaldehida. Tahap kedua adalah sintesis jaringan polimer PNVCL terikat silang N, N'-metilenbisakrilamida (MBA) melalui polimerisasi radikal bebas monomer NVCL dengan inisiator amonium persulfat (APS). Variasi waktu, rasio kitosan-PNVCL, konsentrasi agen pengikat silang, dan konsentrasi inisiator dipelajari untuk mengetahui kondisi optimum. Kondisi optimum diperoleh pada reaksi 2 jam dengan rasio kitosan/NVCL 90:10 (b/b %), konsentrasi MBA 0,5% b/v, dan konsentrasi APS 3% b/v. HSA kitosan-PNVCL memberikan rasio swelling 380,66% dan derajat ikat silang 60,85%. Karakterisasi HSA dilakukan dengan spektrofotometer Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Thermogravimetric analysis (TGA), Scanning Electron Microscope (SEM), dan X-Ray Diffraction (XRD). AbstractPolymer material used for hydrogel should have capability to swell and to keep water molecules in its structure without solubilised in water. Natural polymers has functional groups which can perform as active sites in modification to produce polymer with better characteristic. Chitosan is a natural polymer which has good swelling ability but lack of structural strength. Synthesis of chitosan hydrogel by interpenetrating polymer network (IPN) will increase its strength through crosslinking. In this research, the first step of modification was the synthesis of chitosan polymer network crosslinked by acetaldehyde. The next step was the synthesis of PNVCL polymer network crosslinked by N,N-methylbisacrylamide (MBA) through free radical polymerization of NVCL monomer with ammonium persulfat (APS) as the initiatior. Optimum reaction time, chitosan/ PNVCL ratio (w/w %), concentration of crosslinker agent, and concentration of initiator had been observed. The optimum conditions were obtained as followed: 2 hours reaction, the ratio chitosan/PNVCL of 90:10 (w/w %), %-w MBA concentration of 0,5%, and APS concentration of 3%. The swelling ratio of the hydrogel was 380,66% while the crosslinking degree was 60,85%. Fourier transfor infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Thermogravimetric analysis (TGA), Scanning Electron Microscope (SEM), and X-Ray diffraction (XRD) were used for the characterization of the hydrogel.

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“…So, the signals coupled into the drop port and through port give the phase difference center wave length at 1.4 -1.5 µm. The input and control fields at the input are formed by the dark -bright optical solitons as described by the authors in reference [22]. A PANDA ring is a form of modified optical add-drop filter that can be applied to many applications by changing the structure of PANDA and signals, in which the major behaviors are the two nonlinear side rings that can bring the nonlinear effects coupling to the center ring.…”

Section: Principlementioning

confidence: 99%

“…In addition, the use of drug delivery networks has also been proposed for long distance and long lasting applications [19][20][21]. Recently, the technique of drug delivery security for long distance use has been proposed [22], where the drug transport can be managed by the trapping tool known as an optical capsule, in which the secure drug delivery requirement for long distance within the capsule is plausible. However, the one missing point is that the un-secure capsule is still required for targeting applications, in which the switching control function is required.…”

Section: Introductionmentioning

confidence: 99%

Drug Delivery Targeting Security by Optical Capsule Switching Control

Punthawanunt¹,

Yupapin²

2014

J Biosens Bioelectron

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In this paper, the use of optical capsule for drug delivery with security is proposed. In principle, the optical capsules are generated and formed by soliton pulses within a small scale optical waveguide. The trapped molecules (drug molecules) are brought and stably confined within the device, which can move and deliver securely by the capsule gradient force to the required targets. By using the optical switching control, the trapped drugs within the specific capsules can leave to the access points via the through or drop port, where in this case the switching control is employed by light via the control port (add port). Simulation results obtained have shown that the capsule array can also be constructed and formed the large volume of drug delivery, while the switching control can form the uncapsule drugs into the drug target points. In application, the capsule array can be generated and formed the life molecule trapping, which can be available for life molecule transport within the device, for instance, stem cells, which is useful for stem cells dynamically movement, i.e. transportation to the required targets or organs.

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Interpenetrating Polymer Networks polysaccharide hydrogels for drug delivery and tissue engineering

Cited by 498 publications

References 109 publications

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

Photochemical Production of Interpenetrating Polymer Networks; Simultaneous Initiation of Radical and Cationic Polymerization Reactions

Sintesis dan Karakterisasi Hidrogel Superabsorben Kitosan Poli(N-Vinilkaprolaktam) (Pnvcl) Dengan Metode Full IPN (Interpenetrating Polymer Network)

Drug Delivery Targeting Security by Optical Capsule Switching Control

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