Interpersonal traits of psychopathy linked to reduced integrity of the uncinate fasciculus

Wolf, Richard C.; Pujara, Maia; Motzkin, Julian C.; Newman, Joseph P.; Kiehl, Kent A.; Decety, Jean; Kosson, David S.; Koenigs, Michael

doi:10.1002/hbm.22911

Cited by 83 publications

(75 citation statements)

References 38 publications

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“…In this study, the brain abnormality of ASPD appear in both temporal and frontal lobes, which is consistent with prior studies in aggression-prone individuals (Sundram et al 2012; Wolf et al 2015; Hoppenbrouwers et al 2013). Certain types of antisocial activities are closely linked with frontal-temporal dysfunction, with joint abnormalities of the two regions predisposing some patients to antisocial behaviors (Miller et al 1997).…”

Section: Discussionsupporting

confidence: 93%

“…Furthermore, an impaired emotion-cognition interaction in psychopaths is involved in changed prefrontal and temporal brain activation (Muller et al 2008b). As a result of these findings, some studies have put forward theories that fronto-temporal brain abnormalities are associated with antisocial behavior disorders (Blair and Mitchell 2009), which were verified continuously (Sundram et al 2012; Wolf et al 2015; Hoppenbrouwers et al 2013). …”

Section: Discussionmentioning

confidence: 99%

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Disrupted functional connectome in antisocial personality disorder

Jiang

Shi

Jian

et al. 2016

Brain Imaging and Behavior

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Studies on antisocial personality disorder (ASPD) subjects focus on brain functional alterations in relation to antisocial behaviors. Neuroimaging research has identified a number of focal brain regions with abnormal structures or functions in ASPD. However, little is known about the connections among brain regions in terms of inter-regional whole-brain networks in ASPD patients, as well as possible alterations of brain functional topological organization. In this study, we employ resting-state functional magnetic resonance imaging (R-fMRI) to examine functional connectome of 32 ASPD patients and 35 normal controls by using a variety of network properties, including small-worldness, modularity, and connectivity. The small-world analysis reveals that ASPD patients have increased path length and decreased network efficiency, which implies a reduced ability of global integration of whole-brain functions. Modularity analysis suggests ASPD patients have decreased overall modularity, merged network modules, and reduced intra- and inter-module connectivities related to frontal regions. Also, network-based statistics show that an internal sub-network, composed of 16 nodes and 16 edges, is significantly affected in ASPD patients, where brain regions are mostly located in the fronto-parietal control network. These results suggest that ASPD is associated with both reduced brain integration and segregation in topological organization of functional brain networks, particularly in the fronto-parietal control network. These disruptions may contribute to disturbances in behavior and cognition in patients with ASPD. Our findings may provide insights into a deeper understanding of functional brain networks of ASPD.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Disrupted functional connectome in antisocial personality disorder

Jiang

Shi

Jian

et al. 2016

Brain Imaging and Behavior

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“…Nonetheless, these analyses yielded a high intraclass correlation ( r = .99) for PCL-R total scores; Factor scores (Factor 1, r = .92; Factor 2, r = .89) and Facet scores (Facet 1, r = .88; Facet 2, r = .99; Facet 3, r = .80; Facet 4, r = .88). This is consistent with previously reported PCL-R inter-rater reliabilities from our research group (Dargis et al, 2015; Philippi et al, 2015; Wolf et al, 2015). 40% of the current sample met criteria for psychopathy (PCL-R score ≥30).…”

Section: Methodssupporting

confidence: 93%

Witnessing domestic violence during childhood is associated with psychopathic traits in adult male criminal offenders.

Dargis¹,

Koenigs²

2017

Law and Human Behavior

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While there is growing evidence that suffering physical abuse during childhood is subsequently associated with psychopathic traits in both juvenile and adult offenders, there is considerably less research on whether exposure to domestic violence as a witness, rather than as a direct victim, influences the subsequent presentation of psychopathic traits in adulthood. Accordingly, the current study examined the relationship between witnessing domestic violence during childhood (i.e., witnessing, hearing, or intervening in abuse against a parent/sibling) and psychopathic traits in adulthood in a sample of n = 127 incarcerated male offenders. As predicted, witnessing domestic violence was significantly associated with overall level of psychopathy, with a particularly strong relationship to the interpersonal/affective features of psychopathy. Importantly, this relationship held when controlling for the experience of domestic violence as a direct victim. These results add to the growing body of literature linking adverse and traumatic events during childhood with psychopathic traits later in life, and suggest that domestic violence exposure may be one factor contributing to the manipulative, interpersonal style exhibited by individuals high in psychopathy.

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“…Those studies showed a positive link between increased neuroticism and psychopathy-related traits (e.g. lying, manipulativeness, egocentricity), and reduced WM integrity in the uncinate fasciculus, the forceps minor, the corona radiata, the superior longitudinal fasciculus, and the inferior frontooccipital fasciculus (48,49). No published study has, however, investigated the association between WM and personality traits in BD.…”

Section: Introductionmentioning

confidence: 95%