Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation

Михайлов, А. И.; Torrado, Mario

doi:10.1007/s00109-018-1647-4

Cited by 8 publications

(5 citation statements)

References 106 publications

(125 reference statements)

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“…Additionally, TCONS_00075467 adsorbed miR-328 to derepress the downstream target gene L-type voltage-dependent calcium channel subunit α1C expression to alleviate AF electrical remodeling. Several cardiac-specific transcription factors, such as paired-like homeodomain transcription factor 2 (PITX2) and T-Box transcription factor 5 (TBX5), have been shown to be involved in the regulation of ion channel genes and play a role in AF, with decreasing PITX2 level shortening atrial effective refractory period [ 34 , 35 ]. Gore-Panter et al identified a lncRNA gene localized upstream to the PITX2 gene, called PITX2 adjacent non-coding RNA (PANCR) [ 36 ].…”

Section: Lncrnas and Cardiac Electrical Remodelingmentioning

confidence: 99%

The roles of long noncoding RNAs in atrial fibrillation

Beylerli

Beilerli

et al. 2023

Non-coding RNA Research

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Section: Lncrnas and Cardiac Electrical Remodelingmentioning

confidence: 99%

The roles of long noncoding RNAs in atrial fibrillation

Beylerli

Beilerli

et al. 2023

Non-coding RNA Research

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“…A growing number of evidence suggests that putative gene regulatory networks (GRNs), including cardiac-enriched transcription factors (TFs) and its target genes, can play a potentially important role in the process of adaptive and maladaptive atrial rhythm remodeling (90)(91)(92). In addition, the human genome-wide association studies (GWAS) have successfully identified more than 100 genetic sites associated with atrial fibrillation, including genes encoding cardioenriched TFs (93,94).…”

Section: Transcription Factors (Tfs) and Ncrnamentioning

confidence: 99%

A narrative review of non-coding RNAs in atrial fibrillation: potential therapeutic targets and molecular mechanisms

Zhang¹,

Wang²,

Huang³

2021

Ann Transl Med

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Objective: This review summarizes the advances in the study of ncRNAs and atrial remodeling mechanisms to explore potential therapeutic targets and strategies for AF.Background: Atrial fibrillation (AF) is one of the most common arrhythmias, and its morbidity and mortality rates are gradually increasing. Non-coding ribonucleic acid RNAs (ncRNAs) are transcribed from the genome and do not have the ability to be translated into proteins. A growing body of evidence has shown ncRNAs are extensively involved in the pathophysiological processes underlying AF. However, the precise molecular mechanisms of these associations have not been fully elucidated. Atrial remodeling plays a key role in the occurrence and development of AF, and includes electrical remodeling, structural remodeling, and autonomic nerve remodeling. Research has shown that ncRNA expression is altered in the plasma and tissues of AF patients that mediate cardiac excitation and arrhythmia, and is closely related to atrial remodeling.Methods: Literatures about ncRNAs and atrial fibrillation were extensively reviewed to discuss and analyze. Conclusions:The biology of ncRNAs represents a relatively new field of research and is still in an emerging stage. Recent studies have laid a foundation for understanding the molecular mechanisms of AF, future studies aimed at identifying how ncRNAs act on atrial fibrillation to provide potentially promising therapeutic targets for the treatment of atrial fibrillation.

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“…Further, genes related to structural abnormalities are regulated by mir-21, mir-26, mir-29b, mir-30, mir-133 and mir-590 45 . Perturbations of a dynamic expression balance between TFs, such as PITX2, TBX5, ZFHX3, and SHOX2, and corresponding miRNAs may predispose to AF 46 . The possibility of the complex interaction among circRNAs, miRNAs, and mRNAs is also proposed in AF patients 47 .…”

Section: Ncrnasmentioning

confidence: 99%

Epigenetics in atrial fibrillation: A reappraisal

et al. 2021

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Atrial fibrillation (AF) is the most common cardiac arrhythmia and an important cause of morbidity and mortality globally. Atrial remodeling includes changes in ion channel expression and function, structural alterations, and neural remodeling, which create an arrhythmogenic milieu resulting in AF initiation and maintenance. Current therapeutic strategies for AF involving ablation and antiarrhythmic drugs are associated with a relatively high recurrence and pro-arrhythmic side effects respectively. Over the last two decades, to overcome these issues, research has sought to identify the genetic basis for AF thereby gaining insight into the regulatory mechanisms governing its pathophysiology. Despite identification of multiple gene loci associated with AF, none have thus far led to a therapy, indicating additional contributors to pathology. Recently, in the context of expanding knowledge of the epigenome (DNA methylation, histone modifications, and noncoding RNAs), its potential involvement in the onset and progression of AF pathophysiology has started to emerge. Probing the role of various epigenetic mechanisms that contribute to AF may improve our knowledge of this complex disease, identify potential therapeutic targets and facilitate targeted therapies. Here, we provide a comprehensive review of growing epigenetic features involved in AF pathogenesis, and summarize the emerging epigenomic targets for therapy that have been explored in preclinical models of AF.

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Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation

Cited by 8 publications

References 106 publications

The roles of long noncoding RNAs in atrial fibrillation

The roles of long noncoding RNAs in atrial fibrillation

A narrative review of non-coding RNAs in atrial fibrillation: potential therapeutic targets and molecular mechanisms

Epigenetics in atrial fibrillation: A reappraisal

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