Interplay between metabolic energy regulation and memory pathways in Drosophila

Sgammeglia, Noemi; Sprecher, Simon G.

doi:10.1016/j.tins.2022.04.007

Cited by 8 publications

(5 citation statements)

References 57 publications

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“…Interestingly, P1 neurons directly activate a specific subset of dopaminergic neurons that innervate the MB and it drives LTM appetitive olfactory memory formation 46 . The MB is not only a memory regulatory center but also acts as a sleep and feeding regulatory center 47,48 . In this work we have shown that social interaction correlates with increased synaptic plasticity in the MB itself (fig 4).…”

Section: Discussionmentioning

confidence: 99%

Socialization causes long-lasting behavioral changes

Gil-Martí,

Isidro-Mézcua,

Poza-Rodriguez

et al. 2024

Preprint

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In modern human societies, social isolation acts as a negative factor for health and life quality. On the other hand, social interaction also has profound effects on animal and human behaviors, reducing aggressiveness, feeding and loss of sleep. Here, we observe that in the fly Drosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. We find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation.

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Section: Discussionmentioning

confidence: 99%

Socialization causes long-lasting behavioral changes

Gil-Martí,

Isidro-Mézcua,

Poza-Rodriguez

et al. 2024

Preprint

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“…It is tempting to speculate that the limitation of learning capacity may rely on metabolic energy regulation. Brain functions, in particular memory acquisition and consolidation, are highly energy demanding and thus fine regulations of the energy metabolism are crucial ( 80 ). Indeed, appetitive odour-sugar memories in Drosophila are suppressed by satiety while they are promoted by hunger ( 81 ).…”

Section: Discussionmentioning

confidence: 99%

Neuronal correlates of time integration into memories

Frantzmann,

Lamberty,

Braune

et al. 2023

Preprint

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The circadian clock affects a wide range of physiological processes. Of particular interest is the influence of the clock on memory performance, as circadian dysfunction is associated with age- and disease-related decline in memory. In various species it has been shown that memory performance is regulated by the circadian clock. However, the anatomical and functional connection of the circadian clock and memory neurons has not been described in detail so far. This study now identifies that Diuretic hormone 31 (DH31)-positive clock neurons of the DN1p cluster regulate memory performance. DH31, a functional homolog of the mammalian calcitonin gene-related peptide, plays a crucial role in this process as a clock communication signal. DH31 facilitates memory performance during the night via indirect signalling, while DH31 signals directly to the mushroom bodies restricting memory performance specifically in the evening. This pleiotropic action of DH31 suggests that the circadian clock confines memory performance to a physiological dynamic range.

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“…However, they also receive visual, gustatory, temperature and humidity inputs [74]. Furthermore, mushroom bodies are under influence of the sleep-wake, metabolic and energy state of the fly (including hunger and thirst), and after integrating these signals they play roles in activity and sleep, control of context-dependent foraging and feeding, and coordination of motor behaviour [74,[137][138][139][140].…”

Section: Neuromodulation In Circuits Supervising Behaviours: Endocrin...mentioning

confidence: 99%

Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions

Nässel

Zandawala

2022

Open Biol.

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Plasticity in animal behaviour relies on the ability to integrate external and internal cues from the changing environment and hence modulate activity in synaptic circuits of the brain. This context-dependent neuromodulation is largely based on non-synaptic signalling with neuropeptides. Here, we describe select peptidergic systems in the Drosophila brain that act at different levels of a hierarchy to modulate behaviour and associated physiology. These systems modulate circuits in brain regions, such as the central complex and the mushroom bodies, which supervise specific behaviours. At the top level of the hierarchy there are small numbers of large peptidergic neurons that arborize widely in multiple areas of the brain to orchestrate or modulate global activity in a state and context-dependent manner. At the bottom level local peptidergic neurons provide executive neuromodulation of sensory gain and intrinsically in restricted parts of specific neuronal circuits. The orchestrating neurons receive interoceptive signals that mediate energy and sleep homeostasis, metabolic state and circadian timing, as well as external cues that affect food search, aggression or mating. Some of these cues can be triggers of conflicting behaviours such as mating versus aggression, or sleep versus feeding, and peptidergic neurons participate in circuits, enabling behaviour choices and switches.

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Interplay between metabolic energy regulation and memory pathways in Drosophila

Cited by 8 publications

References 57 publications

Socialization causes long-lasting behavioral changes

Socialization causes long-lasting behavioral changes

Neuronal correlates of time integration into memories

Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions

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