Interplay between mycobacteria and host signalling pathways

Koul, Anil; Herget, Thomas; Klebl, Bert; Ullrich, Axel

doi:10.1038/nrmicro840

Cited by 338 publications

(334 citation statements)

References 116 publications

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“…The success of a pathogen to establish an infection in the host relies on its ability to counter the continuous onslaught mounted by the host to clear off the infection [6]. The mediators of virulence in the bacterial system are often the moonlighting proteins, which are the primary weapons for the host targeting and thus needs our immediate attention.…”

Section: Discussionmentioning

confidence: 99%

“…The success of Mtb lies in its potential to arrest the phagosome maturation thereby creating a safe haven for its survival. The host on the other hand actively initiates signaling cascades in the infected cells [6]. The DCs and macrophages reach the lymph nodes and the infection is thus communicated to the lymphoid cells.…”

Section: Mycobacterium Tuberculosismentioning

confidence: 99%

“…The modulations carried out in the host are executed most efficiently and rapidly through disruptions in the host signaling network [6]. Signaling molecules such as bacterial kinases and phosphatases are most proficient in carrying out this desired role.…”

Section: Mycobacterium Tuberculosismentioning

confidence: 99%

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Bacterial Virulence Factors: Secreted for Survival

et al. 2016

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Virulence is described as an ability of an organism to infect the host and cause a disease. Virulence factors are the molecules that assist the bacterium colonize the host at the cellular level. These factors are either secretory, membrane associated or cytosolic in nature. The cytosolic factors facilitate the bacterium to undergo quick adaptive-metabolic, physiological and morphological shifts. The membrane associated virulence factors aid the bacterium in adhesion and evasion of the host cell. The secretory factors are important components of bacterial armoury which help the bacterium wade through the innate and adaptive immune response mounted within the host. In extracellular pathogens, the secretory virulence factors act synergistically to kill the host cells. In this review, we revisit the role of some of the secreted virulence factors of two human pathogens: Mycobacterium tuberculosis-an intracellular pathogen and Bacillus anthracis-an extracellular pathogen. The advances in research on the role of secretory factors of these pathogens during infection are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Mycobacterium Tuberculosismentioning

confidence: 99%

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Bacterial Virulence Factors: Secreted for Survival

et al. 2016

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“…IFN-gamma is known to play a major role in macrophage activation and inflammation (Koul et al, 2004). The changes in IFN-gamma gene expression in BCG-vaccinated 15 animals ( Fig.…”

mentioning

confidence: 99%

Expression of immunoregulatory genes in peripheral blood mononuclear cells of European wild boar immunized with BCG

Lastra

Galindo

Gortázar

et al. 2009

Veterinary Microbiology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1

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“…2003; Koul et al . 2004; Raman et al . 2010), therefore impairing clearance of infection (Gammack et al .…”

Section: Discussionmentioning

confidence: 99%

An analysis of effects of heterozygosity in dairy cattle for bovine tuberculosis resistance

et al. 2018

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SummaryGenetic selection of cattle more resistant to bovine tuberculosis (bTB) may offer a complementary control strategy. Hypothesising underlying non‐additive genetic variation, we present an approach using genome‐wide high density markers to identify genomic loci with dominance effects on bTB resistance and to test previously published regions with heterozygote advantage in bTB. Our data comprised 1151 Holstein–Friesian cows from Northern Ireland, confirmed bTB cases and controls, genotyped with the 700K Illumina BeadChip. Genome‐wide markers were tested for associations between heterozygosity and bTB status using marker‐based relationships. Results were tested for robustness against genetic structure, and the genotypic frequencies of a significant locus were tested for departures from Hardy‐Weinberg equilibrium. Genomic regions identified in our study and in previous publications were tested for dominance effects. Genotypic effects were estimated through ASReml mixed models. A SNP (rs43032684) on chromosome 6 was significant at the chromosome‐wide level, explaining 1.7% of the phenotypic variance. In the controls, there were fewer heterozygotes for rs43032684 (P < 0.01) with the genotypic values suggesting that heterozygosity confers a heterozygote disadvantage. The region surrounding rs43032684 had a significant dominance effect (P < 0.01). SNP rs43032684 resides within a pseudogene with a parental gene involved in macrophage response to infection and within a copy‐number‐variation region previously associated with nematode resistance. No dominance effect was found for the region on chromosome 11, as indicated by a previous candidate region bTB study. These findings require further validation with large‐scale data.

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Interplay between mycobacteria and host signalling pathways

Cited by 338 publications

References 116 publications

Bacterial Virulence Factors: Secreted for Survival

Bacterial Virulence Factors: Secreted for Survival

Expression of immunoregulatory genes in peripheral blood mononuclear cells of European wild boar immunized with BCG

An analysis of effects of heterozygosity in dairy cattle for bovine tuberculosis resistance

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