2018
DOI: 10.1002/1878-0261.12412
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Interplay between small and long non‐coding RNAs in cutaneous melanoma: a complex jigsaw puzzle with missing pieces

Abstract: The incidence of cutaneous melanoma (CM) has increased in the past few decades. The biology of melanoma is characterized by a complex interaction between genetic, environmental and phenotypic factors. A greater understanding of the molecular mechanisms that promote melanoma cell growth and dissemination is crucial to improve diagnosis, prognostication, and treatment of CM. Both small and long non‐coding RNAs (lncRNAs) have been identified to play a role in melanoma biology; microRNA and lncRNA expression is al… Show more

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Cited by 36 publications
(27 citation statements)
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References 184 publications
(222 reference statements)
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“…In the past few years, a better molecular characterization of BCC phenotype has been obtained using -omics and PCR-based technologies. Specifically, a dysregulated expression of small non-coding RNAs, including microRNAs (miRNAs), has been reported in skin cancers [ 43 ]. miRNAs are small RNAs of 20–24 nucleotides that modulate the expression of a number of genes by binding to the 3’ untranslated region (UTR) of target mRNAs.…”
Section: Bcc Molecular Characteristicsmentioning
confidence: 99%
“…In the past few years, a better molecular characterization of BCC phenotype has been obtained using -omics and PCR-based technologies. Specifically, a dysregulated expression of small non-coding RNAs, including microRNAs (miRNAs), has been reported in skin cancers [ 43 ]. miRNAs are small RNAs of 20–24 nucleotides that modulate the expression of a number of genes by binding to the 3’ untranslated region (UTR) of target mRNAs.…”
Section: Bcc Molecular Characteristicsmentioning
confidence: 99%
“…Manuela Ferracin and colleagues report on the involvement of certain small and long noncoding RNAs in cutaneous melanoma, and the diagnostic and prognostic potential of microRNAs for this disease (Riefolo et al ., ).…”
Section: In This Issuementioning
confidence: 97%
“…The dysregulation of small noncoding RNAs, speci cally microRNAs (miRNAs, 18-22 nucleotides in length), plays a signi cant role in tumorigenesis, including melanoma onset and progression 46 . MiRNAs regulate multiple and speci c target genes, determining an oncogenic or tumor-suppressive function, being implicated in the proliferation, apoptosis and tumor progression.…”
Section: Introductionmentioning
confidence: 99%