Interplay of central and peripheral circadian clocks in energy metabolism regulation

Kolbe, Isa; Brehm, Niklas; Oster, Henrik

doi:10.1111/jne.12659

Cited by 30 publications

(21 citation statements)

References 110 publications

(259 reference statements)

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“…Loss of the SCN pacemaker, for example by surgical lesioning, in mice causes a gradual desynchronization of rhythmicity in peripheral tissues. In rats with ablated SCN, the normal diurnal adrenal corticosterone rhythm is no longer detectable (Kolbe et al 2018).…”

Section: Introductionmentioning

confidence: 96%

Clock genes and cancer development in particular in endocrine tissues

Angelousi

Kassi

Ansari-Nasiri

et al. 2019

Endocrine-Related Cancer

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Circadian rhythms at a central and peripheral level are operated by transcriptional/translational feedback loops involving a set of genes called ‘clock genes’ that have been implicated in the development of several diseases, including malignancies. Dysregulation of the Clock system can influence cancer susceptibility by regulating DNA damage and repair mechanisms, as well as apoptosis. A number of oncogenic pathways can be dysregulated via clock genes’ epigenetic alterations, including hypermethylation of clock genes’ promoters or variants of clock genes. Clock gene disruption has been studied in breast, lung and prostate cancer, and haematological malignancies. However, it is still not entirely clear whether clock gene disruption is the cause or the consequence of tumourigenesis and data in endocrine neoplasms are scarce. Recent findings suggest that clock genes are implicated in benign and malignant adrenocortical neoplasias. They have been also associated with follicular and papillary thyroid carcinomas and parathyroid adenomas, as well as pituitary adenomas and craniopharyngiomas. Dysregulation of clock genes is also encountered in ovarian and testicular tumours and may also be related with their susceptibility to chemotherapeutic agents. The most common clock genes that are implicated in endocrine neoplasms are PER1, CRY1; in most cases their expression is downregulated in tumoural compared to normal tissues. Although there is still a lot to be done for the better understanding of the role of clock genes in endocrine tumourigenenesis, existing evidence could guide research and help identify novel therapeutic targets aiming mainly at the peripheral components of the clock gene system.

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Section: Introductionmentioning

confidence: 96%

Clock genes and cancer development in particular in endocrine tissues

Angelousi

Kassi

Ansari-Nasiri

et al. 2019

Endocrine-Related Cancer

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“…There are obvious circadian rhythmic changes in the process of maintaining homeostasis and adapting to the external environment [1]. The circadian rhythm refers to an approximately 24 h biological rhythm produced by the endogenous circadian oscillator [2]. The central pacemaker of this rhythm is located in the suprachiasmatic nucleus (SCN) of the hypothalamus.…”

Section: Introductionmentioning

confidence: 99%

Circadian protein BMAL1 promotes breast cancer cell invasion and metastasis by up-regulating matrix metalloproteinase9 expression

Wang

et al. 2019

Cancer Cell Int

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Background Metastasis is an important factor in the poor prognosis of breast cancer. As an important core clock protein, brain and muscle arnt-like 1 (BMAL1) is closely related to tumorigenesis. However, the molecular mechanisms that mediate the role of BMAL1 in invasion and metastasis remain largely unknown. In this study, we investigated the BMAL1 may take a crucial effect in the progression of breast cancer cells. Methods BMAL1 and MMP9 expression was measured in breast cell lines. Transwell and scratch wound-healing assays were used to detect the movement of cells and MTT assays and clonal formation assays were used to assess cells’ proliferation. The effects of BMAL1 on the MMP9/NF-κB pathway were examined by western blotting, co-immunoprecipitation and mammalian two-hybrid. Results In our study, it showed that cell migration and invasion were significantly enhanced when overexpressed BMAL1. Functionally, overexpression BMAL1 significantly increased the mRNA and protein level of matrix metalloproteinase9 (MMP9) and improved the activity of MMP9. Moreover, BMAL1 activated the NF-κB signaling pathway by increasing the phosphorylation of IκB and promoted human MMP9 promoter activity by interacting with NF-kB p65, leading to increased expression of MMP9. When overexpressed BMAL1, CBP (CREB binding protein) was recruited to enhance the activity of p65 and further activate the NF-κB signaling pathway to regulate the expression of its downstream target genes, including MMP9, TNFα, uPA and IL8, and then promote the invasion and metastasis of breast cancer cells. Conclusions This study confirmed a new mechanism by which BMAL1 up-regulated MMP9 expression to increase breast cancer metastasis, to provide research support for the prevention and treatment of breast cancer.

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“…Similar to rodents (Peripheral clocks control cell and organ physiology: lessons from rodent studies), also in human individuals there is accumulating evidence that metabolic, cardiovascular, endocrine, digestive, and immune functions follow diurnal rhythms (Fig. 3) [47,222,224,225,227,228,281,[369][370][371][372][373]375]. Although molecular clock studies in humans stay a challenging endeavor, analyses conducted in human saliva, serum, and urine serial samples obtained across 24 h revealed that large number of metabolites exhibits circadian rhythmic profiles [143,221,[376][377][378].…”

Section: The Circadian Clock System and Human Diseasesmentioning

confidence: 99%

Coupled network of the circadian clocks: a driving force of rhythmic physiology

2020

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The circadian system is composed of coupled endogenous oscillators that allow living beings, including humans, to anticipate and adapt to daily changes in their environment. In mammals, circadian clocks form a hierarchically organized network with a ‘master clock’ located in the suprachiasmatic nucleus of the hypothalamus, which ensures entrainment of subsidiary oscillators to environmental cycles. Robust rhythmicity of body clocks is indispensable for temporally coordinating organ functions, and the disruption or misalignment of circadian rhythms caused for instance by modern lifestyle is strongly associated with various widespread diseases. This review aims to provide a comprehensive overview of our current knowledge about the molecular architecture and system‐level organization of mammalian circadian oscillators. Furthermore, we discuss the regulatory roles of peripheral clocks for cell and organ physiology and their implication in the temporal coordination of metabolism in human health and disease. Finally, we summarize methods for assessing circadian rhythmicity in humans.

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Interplay of central and peripheral circadian clocks in energy metabolism regulation

Cited by 30 publications

References 110 publications

Clock genes and cancer development in particular in endocrine tissues

Clock genes and cancer development in particular in endocrine tissues

Circadian protein BMAL1 promotes breast cancer cell invasion and metastasis by up-regulating matrix metalloproteinase9 expression

Coupled network of the circadian clocks: a driving force of rhythmic physiology

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