2023
DOI: 10.1002/pgr2.10
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Interplay of heparan sulfate chains with the core proteins of syndecans 2 and 4

Martyna Maszota‐Zieleniak,
Adam Liwo,
Sylvie Ricard‐Blum
et al.

Abstract: We have previously shown that the extracellular domains of the four syndecans are intrinsically disordered, and adopt a wide range of conformations. We report here the building of coarse‐grained models of the extracellular domains of human syndecans 2 and 4 using small‐angle X‐ray scattering restraints. One, two or three heparan sulfate (HS) hexadecasaccharides, (IdoA[2S]GlcNS[6S])8, were attached to three serine residues of the core proteins, resulting in eight variants for each syndecan that were used for al… Show more

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