Interplay of Nutrition and Psychoneuroendocrineimmune Modulation: Relevance for COVID-19 in BRICS Nations

Mehta, Arundhati; Ratre, Yashwant Kumar; Sharma, Krishna Kant; Soni, Vivek Kumar; Tiwari, Atul; Singh, Rajat; Dwivedi, Mrigendra; Chandra, Vikas; Prajapati, Santosh Kumar; Shukla, Dhananjay; Vishvakarma, Naveen Kumar

doi:10.3389/fmicb.2021.769884

Cited by 5 publications

(3 citation statements)

References 156 publications

(393 reference statements)

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“…Similarly, high mortality rates after SARS-CoV-2 infection have been observed in patients with schizophrenia (Nemani et al, 2021). Interactions between the brain and immune system, already known from psycho-neuro-immunological research, have been observed in the COVID-19 pandemic (Mehta et al, 2021).…”

Section: Introductionmentioning

confidence: 88%

Relationship between depression, anxiety, stress, and SARS-CoV-2 infection: a longitudinal study

Ausserhofer

Mahlknecht²,

Engl³

et al. 2023

Front. Psychol.

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ObjectivesWe aimed to (1) describe the course of the emotional burden (i.e., depression, anxiety, and stress) in a general population sample during the coronavirus pandemic in 2020 and 2021 and (2) explore the association between emotional burden and a serologically proven infection with SARS-CoV-2.Study designThis longitudinal study involved a sample of community-dwelling persons aged ≥14 years from the general population of South Tyrol (Province of Bolzano-Bozen, Northern Italy). Data were collected at two stages over a 1-year period in 2020 and 2021.MethodsPersons were invited to participate in a survey on socio-demographic, health-related and psychosocial variables (e.g., age, chronic diseases, Depression Anxiety Stress Scale, DASS-21), as well as in the serological testing for of SARS-CoV-2-specific immunoglobulins.ResultsIn 2020, 855 (23.8%) out of 3,600 persons participated; in 2021, 305 (35.7%) out of 855 were tested again. We observed a statistically significant decrease in mean DASS-21 scores for depression, stress, and total scores between 2020 and 2021, yet not for anxiety. Persons with a confirmed SARS-CoV-2-infection between the first and second data collection exhibited increased emotional burden compared to those without SARS-CoV-2-infection. The odds of participants with a self-reported diagnosis of mental disorder for future infection with SARS-CoV-2 was almost four times higher than that of participants without mental disorders (OR:3.75; 95%CI:1.79-7.83).ConclusionOur findings support to the hypothesis of a psycho-neuroendocrine-immune interplay in COVID-19. Further research is necessary to explore the mechanisms underlying the interplay between mental health and SARS-CoV-2 infections.

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Section: Introductionmentioning

confidence: 88%

Relationship between depression, anxiety, stress, and SARS-CoV-2 infection: a longitudinal study

Ausserhofer

Mahlknecht²,

Engl³

et al. 2023

Front. Psychol.

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“…Uptake of lipid moieties from exterior their exterior is shown to affect the cancer cell physiology and assist in upholding stemness in a variety of malignancies. Moreover, the import of FA into cytosol has a critical impact on the malignant transformation of cells ( 87 , 111 ). Research investigations have shown that lipid uptake is upregulated in lymphoma cells ( 96 ).…”

Section: Lipid Sequestration In T-cell Malignanciesmentioning

confidence: 99%

Orchestral role of lipid metabolic reprogramming in T-cell malignancy

Mehta

Ratre

Soni³

et al. 2023

Front. Oncol.

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The immune function of normal T cells partially depends on the maneuvering of lipid metabolism through various stages and subsets. Interestingly, T-cell malignancies also reprogram their lipid metabolism to fulfill bioenergetic demand for rapid division. The rewiring of lipid metabolism in T-cell malignancies not only provides survival benefits but also contributes to their stemness, invasion, metastasis, and angiogenesis. Owing to distinctive lipid metabolic programming in T-cell cancer, quantitative, qualitative, and spatial enrichment of specific lipid molecules occur. The formation of lipid rafts rich in cholesterol confers physical strength and sustains survival signals. The accumulation of lipids through de novo synthesis and uptake of free lipids contribute to the bioenergetic reserve required for robust demand during migration and metastasis. Lipid storage in cells leads to the formation of specialized structures known as lipid droplets. The inimitable changes in fatty acid synthesis (FAS) and fatty acid oxidation (FAO) are in dynamic balance in T-cell malignancies. FAO fuels the molecular pumps causing chemoresistance, while FAS offers structural and signaling lipids for rapid division. Lipid metabolism in T-cell cancer provides molecules having immunosuppressive abilities. Moreover, the distinctive composition of membrane lipids has implications for immune evasion by malignant cells of T-cell origin. Lipid droplets and lipid rafts are contributors to maintaining hallmarks of cancer in malignancies of T cells. In preclinical settings, molecular targeting of lipid metabolism in T-cell cancer potentiates the antitumor immunity and chemotherapeutic response. Thus, the direct and adjunct benefit of lipid metabolic targeting is expected to improve the clinical management of T-cell malignancies.

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“…Studies have shown that the ecological footprint of BRICS countries is decreasing, which means that green health may become a new priority [ 57 ]. There is also growing concern about mental health in BRICS countries, which has been exacerbated by the COVID-19 pandemic [ 58 ]. Furthermore, with more people moving into the cities, the health challenges brought by urbanization should also be noticed.…”

Section: Possible Pathways For Brics Future Health Cooperationmentioning

confidence: 99%

The priority areas and possible pathways for health cooperation in BRICS countries

Liu,

Wang,

et al. 2023

glob health res policy

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As one of the largest alliances of middle-income countries, the BRICS, known as an acronym for five countries including “Brazil, Russia, India, China, and South Africa”, represents half of the global population. The health cooperation among BRICS countries will benefit their populations and other middle- and low-income countries. This study aims to summarize the current status of health cooperation in BRICS countries and identify opportunities to strengthen BRICS participation in global health governance. A literature review was conducted to analyze the status, progress, and challenges of BRICS' health cooperation. Content analysis was used to review the 2011–2021 annual joint declarations of the BRICS Health Ministers Meetings. The priority health areas were identified through segmental frequency analysis. Our research suggested that communicable diseases, access to medicine, and universal health coverage appeared most frequently in the content of declarations, indicating the possible top health priorities among BRICS' health collaboration. These priority areas align with the primary health challenges of each country, including the threats of double burden of diseases, as well as the need for improving health systems and access to medicines. Respective external cooperation, inter-BRICS health cooperation, and unified external cooperation are the main forms of health cooperation among BRICS countries. However, challenges such as the lack of a unified image and precise position, lack of practical impact, and weak discourse power have impeded the impact of BRICS on health governance. This study suggests that the BRICS countries should recognize their positioning, improve their unified image, and establish cooperative entities; at the same time, they should increase their practical strength, promote non-governmental cooperation, and expand the cooperation space through the “BRICS Plus” mechanism with countries with similar interests to join.

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Interplay of Nutrition and Psychoneuroendocrineimmune Modulation: Relevance for COVID-19 in BRICS Nations

Cited by 5 publications

References 156 publications

Relationship between depression, anxiety, stress, and SARS-CoV-2 infection: a longitudinal study

Relationship between depression, anxiety, stress, and SARS-CoV-2 infection: a longitudinal study

Orchestral role of lipid metabolic reprogramming in T-cell malignancy

The priority areas and possible pathways for health cooperation in BRICS countries

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