Interplay of Ritonavir-Boosted Oral Cabazitaxel with the Organic Anion-Transporting Polypeptide (OATP) Uptake Transporters and Carboxylesterase 1 in Mice
Nancy H.C. Loos,
Margarida L. Ferreira Martins,
Jamie Rijmers
et al.
Abstract:Intravenously administered chemotherapeutic
cabazitaxel is used
for palliative treatment of prostate cancer. An oral formulation would
be more patient-friendly and reduce the need for hospitalization.
We therefore study determinants of the oral pharmacokinetics of cabazitaxel
in a ritonavir-boosted setting, which reduces the CYP3A-mediated first-pass
metabolism of cabazitaxel. We here assessed the role of organic anion-transporting
polypeptides (OATPs) in the disposition of orally boosted cabazitaxel
and its a… Show more
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