We introduce connections between the Cuntz relations and the Hardy space H 2 of the open unit disk D. We then use them to solve a new kind of multipoint interpolation problem in H 2 , where for instance, only a linear combination of the values of a function at given points is preassigned, rather than the values at the points themselves.1991 Mathematics Subject Classification. 42C40, 47A57, 93B28. Key words and phrases. Cuntz relations, Leech's theorem, Schur analysis. D. Alpay thanks the Earl Katz family for endowing the chair which supported his research. The work was done in part while the second named author visited Department of Mathematics, Ben Gurion University of the Negev, supported by a BGU distinguished visiting scientist program. Support and hospitality is much appreciated. We acknowledge discussions with colleagues there, and in the US, Dorin Dutkay, Myung-Sin Song, and Erin Pearse.