Interpolymer complex microparticles based on polymethacrylic acid‐chitosan for oral insulin delivery

Sajeesh, S.; Sharma, Chandra P.

doi:10.1002/app.22311

Cited by 41 publications

(2 citation statements)

References 38 publications

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“…The cumulative BSA release profiles are depicted in Figure 5. In all cases, the initial burst release of the protein (within the first one to two hours) governed by the desorption of the protein molecules associated with the surface of the microparticles was followed by a stage of slower release that can be attributed to swelling of the chitosan matrix and diffusion of the protein from the micropores of the particles [43]. BSA release is shown to be dependent on the degree of cross-linking of the chitosan matrix.…”

Section: In Vitro Bsa Releasementioning

confidence: 93%

Modulation of Entrapment Efficiency and In Vitro Release Properties of BSA-Loaded Chitosan Microparticles Cross-Linked with Citric Acid as a Potential Protein–Drug Delivery System

et al. 2020

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Microparticles, aimed for oral protein and peptide drug delivery, were prepared via emulsion cross-linking using citric acid as cross-linker and polyglycerol polyricinoleate as surfactant. A comparative study of the interaction between chitosan and citric acid and its effect on the resulting microparticle properties was performed using different chitosan-to-cross-linker mass ratios and pH-values during fabrication of the microparticles. Non-cross-linked and cross-linked microparticles were studied in terms of size (4–12 μm), zeta potential (−15.7 to 12.8 mV), erosion (39.7–75.6%), a model protein encapsulation efficiency (bovine serum albumin) (6.8–27.6%), and loading capacity (10.4–40%). Fourier transform infrared spectroscopy and X-ray diffraction confirmed the ionic interaction between the protonated amine groups of chitosan and the carboxylate ions of the cross-linking agent. Scanning electron microscopy revealed that the non-cross-linked microparticles had an uneven shape with wrinkled surfaces, while the cross-linked formulations were spherical in shape with smooth surfaces. On the basis of these data, the role of the surfactant and microparticle structure on the release mechanism was proposed. Control of the microparticle shape and release mechanisms is expected to be crucial in developing carriers for the controlled delivery of proteins and peptides.

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Section: In Vitro Bsa Releasementioning

confidence: 93%

Modulation of Entrapment Efficiency and In Vitro Release Properties of BSA-Loaded Chitosan Microparticles Cross-Linked with Citric Acid as a Potential Protein–Drug Delivery System

et al. 2020

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“…Calculated amount of dried nanogels were added into drug solution, sonicated for 15 min, and then placed on magnetic stirrer at 500 r/min for 72 h. After 72 h, drug-loaded nanogels were subjected to lyophilization. 16 TBH-loaded nanogels were then physically and chemically characterized.…”

Section: Methodsmentioning

confidence: 99%

Development and Evaluation of pH-Responsive Pluronic F 127 Co-Poly- (Acrylic Acid) Biodegradable Nanogels for Topical Delivery of Terbinafine HCL

et al. 2022

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Research aimed to develop and evaluate biodegradable, pH-responsive chemically cross-linked Pluronic F127 co-poly- (acrylic acid) nanogels for dermal delivery of Terbinafine HCL (TBH) to increase its permeability and as a new approach to treat skin fungal infections. TBH-loaded nanogels were successfully synthesized from acrylic acid (AA) and Pluronic F127 by free-radical copolymerization technique using N,N′-methylene bisacrylamide (MBA) as crosslinker and ammonium persulphate (APS) as initiator. Prepared nanogels exhibited 93.51% drug entrapment efficiency (DEE), 45 nm particle size, pH-dependent swelling and release behavior. Nanogels were characterized using different physicochemical techniques. The ex-vivo skin retention studies through rat skin showed about 42.34% drug retention from nanogels while 1% Lamisil cream (marketed product) showed about 26.56% drug retention. Moreover, skin irritation studies showed that nanogels were not irritating. Nanogels showed improved in-vitro antifungal activity against Candida albicans compared to commercial product. In-vivo studies on rats infected with Candida albicans confirmed superiority of nanogels over 1% Lamisil for eradication of fungal infection. This confirms that TBH loaded in Pluronic F127 co-poly-(acrylic acid) nanogels provided greater targetibility and cure rates of poorly soluble TBH in animal model and hence nanogels could be a potential carrier for effective topical delivery of TBH for skin fungal infection treatment.

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Development of Acyclovir Loaded β‐Cyclodextrin‐g‐Poly Methacrylic Acid Hydrogel Microparticles: An In Vitro Characterization

et al. 2016

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In this work, successful efforts have been performed for solubility enhancement of acyclovir. pH‐sensitive β‐Cyclodextrin‐g‐poly methacrylic acid (MAA) hydrogel microparticles were developed. β‐Cyclodextrin, MAA, N,N‐methylene bisacrylamide were used as polymer, monomer, and cross‐linker, respectively. Nine different formulations (BM‐1 to BM‐9) were prepared by aqueous free radical polymerization. Developed microparticles were characterized for FTIR, Differential Scanning Calorimetry/Thermo Gravimetric Analysis, PXRD, energy‐dispersive x‐ray spectroscopy, SEM, TEM, optical microscopy, zeta sizer, percent equilibrium swelling (%ES), solubility studies, and in vitro drug release studies. Higher swelling results (83.68%) were obtained at pH 7.4 in less than 3 h. Porous surfaces with drug were seen in TEM images. Maximum release was observed at pH 7.4 (89.51%). Solubility enhancement was 7.38‐fold in water as compared to pure acyclovir. Thermal stability of grafted microparticles was increased up to 440.13°C. A potential approach for solubility enhancement was successfully developed.

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Interpolymer complex microparticles based on polymethacrylic acid‐chitosan for oral insulin delivery

Cited by 41 publications

References 38 publications

Modulation of Entrapment Efficiency and In Vitro Release Properties of BSA-Loaded Chitosan Microparticles Cross-Linked with Citric Acid as a Potential Protein–Drug Delivery System

Modulation of Entrapment Efficiency and In Vitro Release Properties of BSA-Loaded Chitosan Microparticles Cross-Linked with Citric Acid as a Potential Protein–Drug Delivery System

Development and Evaluation of pH-Responsive Pluronic F 127 Co-Poly- (Acrylic Acid) Biodegradable Nanogels for Topical Delivery of Terbinafine HCL

Development of Acyclovir Loaded β‐Cyclodextrin‐g‐Poly Methacrylic Acid Hydrogel Microparticles: An In Vitro Characterization

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