Interpolymer Complexes Based on Cellulose Ethers: Application

Self Cite

Utilizing turbidimetry data, an examination is conducted on the behavior of solutions containing N-vinylpyrrolidone and vinyl propyl ether copolymer within a temperature range coinciding with the occurrence of a phase transition. The investigation reveals that within specific conditions prevailing in this domain, the emergence of entities denoted as hydrophobic–hydrophilic associates is conceivable. These entities are characterized by the presence of a relatively dense core, upheld by hydrophobic interplays, and they are proficient in effectively dispersing irradiation within the optical spectrum. Encircling this core is a hydrophilic periphery that impedes the formation of insoluble precipitates. The development of such associates transpires when hydrophobic interactions have attained a discernible prominence, although they remain inadequate to counteract the forces that drive the expansion of macromolecular coils. Under these circumstances, the energetically favored course of action entails the constitution of a core for the aforementioned associates, involving discrete segments from diverse macromolecules. Notably, the introduction of an additional constituent (ethanol) to the solution, which selectively mitigates hydrophobic interactions, serves to stabilize the hydrophobic–hydrophilic associations.

“…By employing expression (8) and performing a change of variables in the integrand (permissible since the integral is evaluated over infinite limits), we derive…”

Section: 𝑈 + 𝑈 ↔ 𝑈mentioning

confidence: 99%

“…This engrossment stems largely from practical imperatives. Evidently, polymers responsive to stimuli, along with the gels derived from them, hold immense potential as a highly promising substrate for finely tuned drug delivery systems [3,[5][6][7][8], alongside their prospective applications within the realm of biomedicine [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Formation of Hydrophobic–Hydrophilic Associates in the N-Vinylpyrrolidone and Vinyl Propyl Ether Copolymer Aqueous Solutions

Kabdushev,

Mun,

Suleimenov

et al. 2023

Self Cite

“…For example, most cancerous tissues have lower pH values (extracellular tumour pH ≈ 6.4–6.8, endosome pH ≈ 5.5, and lysosome pH ≈ 5.0) than healthy tissue and the bloodstream (pH ≈ 7.4) [ 127 ]. Applying a biocompatible polymer to the MSN surface to seal pores is a promising approach to creating desirable pH- and temperature-sensitive drug delivery systems [ 128 , 129 , 130 , 131 , 132 ]. The use of thermosensitive polymers allows for controlled drug release due to the fundamental differences in temperature between normal and cancerous tissue cells, allowing for tumour selectivity.…”

Section: Stimuli That Control Drug Releasementioning

confidence: 99%

Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs

Kovtareva,

Kusepova,

Tazhkenova

et al. 2024

Self Cite

The problem of tumour therapy has attracted the attention of many researchers for many decades. One of the promising strategies for the development of new dosage forms to improve oncology treatment efficacy and minimise side effects is the development of nanoparticle-based targeted transport systems for anticancer drugs. Among inorganic nanoparticles, mesoporous silica deserves special attention due to its outstanding surface properties and drug-loading capability. This review analyses the various factors affecting the cytotoxicity, cellular uptake, and biocompatibility of mesoporous silica nanoparticles (MSNs), constituting a key aspect in the development of safe and effective drug delivery systems. Special attention is paid to technological approaches to chemically modifying MSNs to alter their surface properties. The stimuli that regulate drug release from nanoparticles are also discussed, contributing to the effective control of the delivery process in the body. The findings emphasise the importance of modifying MSNs with different surface functional groups, bio-recognisable molecules, and polymers for their potential use in anticancer drug delivery systems.

“…Nagai also discovered that using a mucoadhesive polymer enhanced the absorption of peptides when administered nasally [201]. There has been a lot of pioneering work in this field, such as the development of mucoadhesive creams based on poly(acrylic acid) (PAAc) [202] and poly(methyl methacrylate) [203]. The majority of early research on mucoadhesion was done with traditional polymers in the form of tablets [204], powders [205,206], or films [207].…”

Section: Mucoadhesive Biomaterialsmentioning

confidence: 99%

Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials

Harun-Or-Rashid,

Aktar,

Hossain

et al. 2023

Polymeric drug delivery technology, which allows for medicinal ingredients to enter a cell more easily, has advanced considerably in recent decades. Innovative medication delivery strategies use biodegradable and bio-reducible polymers, and progress in the field has been accelerated by future possible research applications. Natural polymers utilized in polymeric drug delivery systems include arginine, chitosan, dextrin, polysaccharides, poly(glycolic acid), poly(lactic acid), and hyaluronic acid. Additionally, poly(2-hydroxyethyl methacrylate), poly(N-isopropyl acrylamide), poly(ethylenimine), dendritic polymers, biodegradable polymers, and bioabsorbable polymers as well as biomimetic and bio-related polymeric systems and drug-free macromolecular therapies have been employed in polymeric drug delivery. Different synthetic and natural biomaterials are in the clinical phase to mitigate different diseases. Drug delivery methods using natural and synthetic polymers are becoming increasingly common in the pharmaceutical industry, with biocompatible and bio-related copolymers and dendrimers having helped cure cancer as drug delivery systems. This review discusses all the above components and how, by combining synthetic and biological approaches, micro- and nano-drug delivery systems can result in revolutionary polymeric drug and gene delivery devices.