Interpolymeric complexes — Biocompatible polymeric materials and the problem of thromboresistance

Зезин, А. Б.; Él'tsefon, B. S.; Rudman, A. R.; Vengerova, N. A.; Kalyuzhnaya, R.I.; Valueva, S. P.; Kopylova, E. M.; Chepurov, A. K.; Efimov, V. S.; Kabanov, V.A.

doi:10.1007/bf00758755

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Kabanov, Zezin, and coworkers have already shown that IPECs show high resistance against thromboformation. 39 Nowadays, IPEC-based systems are already on their way to medically relevant delivery systems. 40…”

Section: Introductionmentioning

confidence: 99%

Micellar interpolyelectrolyte complexes

2012

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Interpolyelectrolyte complexes (IPECs) are typically formed when two polyelectrolytes of opposite charge are mixed together in solution. We present an overview of different strategies for the preparation of micellar IPECs, i.e., structures where such IPEC domains form the core or the shell of micelles. In addition, vesicular architectures are considered, where the IPEC domain forms a membrane layer. One intriguing feature of IPECs is that their formation can be directed, their stability towards changes in pH or ionic strength can (to a certain extent) be predicted, and their size can be controlled. Especially the use of ionic/non-ionic block copolymers offers unique potential for the preparation of well-defined and sophisticated nanostructured materials. We also discuss possible applications, especially in the field of life sciences, including biocompatibility, the controlled uptake/release of guest substances, the immobilization of enzymes, or the controlled formation of inorganic/organic hybrid materials.

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Section: Introductionmentioning

confidence: 99%

Micellar interpolyelectrolyte complexes

2012

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“…Some examples include effective and available binders for dispersed systems and flocculants of colloidal dispersions [2], biocompatible coatings [3,4], components of membranes [5][6][7][8][9][10][11], carriers of biologically active compounds (including enzymes and DNA) [12][13][14][15][16], matrices for metal ions and metal nanoparticles [17][18][19][20][21][22], and the formation of multilayered PE films and capsules using layer-by-layer techniques [23][24][25][26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Interpolyelectrolyte Complexes Based on Polyionic Species of Branched Topology

Pergushov

Borisov

Зезин

et al. 2010

Self Organized Nanostructures of Amphiphilic Block Copolymers I

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“…IPECs were shown to be suitable for the construction of enzymatic systems with controllable activity and stability [9,10], for the preparation of membranes [11,12] and microcapsules [12,13], for the immobilization of microorganisms [14], for the surface modi®cation of solid materials [15,16], etc. The biocompatibility of IPECs is a unique feature that opens many possibilities for their application as coatings for medical materials used in a contact with blood and other biological liquids [17,18].…”

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confidence: 99%

Effect of a low-molecular-weight salt on colloidal dispersions of interpolyelectrolyte complexes

Pergushov

Buchhammer²,

Lunkwitz³

1999

Colloid Polym Sci

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IntroductionIt is well known that electrostatic interaction between oppositely charged macromolecules leads to the formation of interpolyelectrolyte complexes (IPECs) [1]. Such macromolecular assemblies are predominantly stabilized by a cooperative system of interpolymer salt bonds although other intermacromolecular interactions, for example, hydrogen bonding, hydrophobic interactions, charge-transfer interactions, and van der Waals forces, can also play a signi®cant role. The structure and properties of IPECs are determined by a number of factors: the characteristics of the polyelectrolyte components (e.g., nature of ionic groups, degree of polymerization, charge density, etc.) and their concentrations, the ratio between amounts of oppositely charged groups of polyelectrolytes, the conditions of the surrounding medium (e.g., ionic strength, pH, temperAbstract Colloidal dispersions of an interpolyelectrolyte complex were prepared by mixing dilute aqueous solutions of poly(dimethyldiallylammonium chloride) and the sodium salt of the alternating copolymer of maleic acid propene in amounts providing about a threefold excess of the charged groups of the cationic polyelectrolyte over those of the anionic polyelectrolyte. These dispersions were examined by means of analytical sedimentation, quasielastic light scattering, and laser Doppler microelectrophoresis. The experimental results obtained suggest that the particles of the interpolyelectrolyte complex are multicomplex aggregates bearing cationic charge. Such aggregates were assumed to consist of a hydrophobic core formed by coupled oppositely charged macromolecules and a hydrophilic shell formed by cationic macromolecules. Hydrodynamic and electrophoretic properties of these aggregates were found to be rather sensitive to variations in the ionic strength of the surrounding medium: with rising salt concentration, their sedimentation coecient and hydrodynamic size increase, these increases becoming more strongly pronounced at higher salt concentrations, whereas their electrophoretic mobility gradually decreases. The salt eects revealed suggest that the aggregation level of the particles of the interpolyelectrolyte complex rises in response to an increase in the ionic strength of the surrounding medium. This phenomenon was associated with the salt-induced decrease of the stabilizing eect of the hydrophilic shells that protect such particles from progressive aggregation.

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Interpolymeric complexes — Biocompatible polymeric materials and the problem of thromboresistance

Cited by 4 publications

References 13 publications

Micellar interpolyelectrolyte complexes

Micellar interpolyelectrolyte complexes

Interpolyelectrolyte Complexes Based on Polyionic Species of Branched Topology

Effect of a low-molecular-weight salt on colloidal dispersions of interpolyelectrolyte complexes

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