Interpopulation effect of ACE I/D polymorphism on serum concentration of ACE in diagnosis of sarcoidosis

Császár, Albert; Halmos, Balázs; Palicz, Tamás; Szalai, Csaba; Romics, L

doi:10.1016/s0140-6736(05)63108-x

Cited by 17 publications

(11 citation statements)

References 9 publications

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“…te. As a result these studies have showed that frequency of genotypes can be different according to the population (4,(7)(8)(9)(10)(11)(12)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) (8). Although the frequency of the D allele was higher in control subjects and sarcoidosis patients, the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 97%

ACE gene I/D polymorphism and risk of sarcoidosis development in Turkish patients

Yilmaz¹,

Karkucak²,

Çoşkun³

et al. 2012

Tuberk Toraks

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Section: Discussionmentioning

confidence: 97%

ACE gene I/D polymorphism and risk of sarcoidosis development in Turkish patients

Yilmaz¹,

Karkucak²,

Çoşkun³

et al. 2012

Tuberk Toraks

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“…2 The results of individual and summary OR estimates with 95% CI, fixed-effect model: (a) ID/ACE polymorphism-dominant genetic model; (b) ID/ACE polymorphism-recessive genetic model. The size of the square is proportional to the percent weight of each study; horizontal lines represent the 95% CI higher production of sACE in both the general population and sarcoidosis patients (Rigat et al 1990;Tiret et al 1992;Arbustini et al 1996;Furuya et al 1996;Sharma et al 1997;Tomita et al 1997;Csaszar et al 1997). All these findings have contributed to the idea of the ID/ACE polymorphism's involvement in sarcoidosis etiology and/or pathogenesis, but neither the individual studies (except for African Americans) nor our meta-analysis confirmed this idea.…”

Section: Discussionmentioning

confidence: 99%

“…The remaining five studies not included were family-based studies, studies evaluating serum ACE levels or studies evaluating sarcoidosis symptoms (Csaszar et al 1997;Niimi et al1998;Kawakami et al 1998;Schurmann et al 2001;Rybicki et al 2004).…”

Section: Data Extractionmentioning

confidence: 99%

Role of genetic polymorphisms in ACE and TNF-α gene in sarcoidosis: a meta-analysis

et al. 2007

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A great number of association studies have been performed to identify the genes involved in the etiology and prognosis of sarcoidosis. We performed a systematic review of case-control studies through the PubMed database and evaluated them for a possible inclusion into a meta-analysis in order to assess whether the reported genetic polymorphisms are the risk factors of sarcoidosis. Case-control studies with clear diagnostic criteria and interventions were included. Only investigations of a single polymorphism/gene involvement in sarcoidosis reported more than five times were selected. Aggregating data from 12 studies on ID/ACE polymorphisms, the odds ratio (OR) for sarcoidosis, if the polymorphism was considered under the dominant genetic model, was not significantly increased: 1.19 (95% CI 0.98-1.43); OR under the recessive model was 1.20 (95% CI 0.98-1.46). In seven case-control studies on -308/TNF-a polymorphism, the OR for sarcoidosis if the polymorphism considered under the dominant genetic model was significantly increased at 1.47 (95% CI 1.03-2.08); the OR under the recessive model was 1.39 (95% CI 0.67-2.90). In conclusion, the results showed that the TNF-a genotype could be a significant risk factor for sarcoidosis, whereas the risk of sarcoidosis due to the ACE genotype was not substantially elevated.

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“…Of the remaining 25 full-text articles (Arbustini et al, 1996;Furuya et al, 1996;Császár et al, 1997;Sharma et al, 1997;Tomita et al, 1997;Xu et al, 1997;Garrib et al, 1998;Maliarik et al, 1998;Niimi et al, 1998;Takemoto et al, 1998;Pietinalho et al, 1999;Stokes et al, 1999;Papadopoulos et al, 2000;McGrath et al, 2001;Ruprecht et al, 2001;Schürmann et al, 2001;Planck et al, 2002;Alía et al, 2005;Biller et al, 2006;Kruit et al, 2007;Salobir et al, 2007;Tahir et al, 2007;Biller et al, 2009;Kruit et al, 2010;Yilmaz et al, 2012), 2 lacked controls (Stokes et al, 1999;Schürmann et al, 2001), and 2 did not examine patients with sarcoidosis (Ruprecht et al, 2001;Biller et al, 2006); these 4 articles were thus excluded. An additional 3 articles (Császár et al, 1997;Niimi et al, 1998;Kruit et al, 2007) were also excluded because of incomplete reporting of data. Therefore, a total of 18 articles (20 case-control studies, including 1882 cases and 3066 controls) were included in the current meta-analysis examining the association between the I/D polymorphism of the ACE gene and susceptibility to sarcoidosis (Arbustini et al, 1996;Furuya et al, 1996;Sharma et al, 1997;Tomita et al, 1997;…”

Section: Literature Searchmentioning

confidence: 99%

Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk

Zhu

Kong

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence sarcoidosis susceptibility. The strength of the association between I/D polymorphisms and sarcoidosis risk was measured based on the odds ratio and 95% confidence interval. Analysis was based on recessive and dominant models. Ethnic subgroup analysis from 18 articles (1882 cases and 3066 controls) showed that DD homozygote carriers were at a slightly increased risk of sarcoidosis compared with II homozygotes and DI heterozygotes (P = 0.03). Comparison of DD plus DI vs II revealed no significant association with sarcoidosis in group ACE gene and sarcoidosis and ethnic subgroup analysis. We found that the I/D polymorphism in the angiotensin-converting enzyme gene was not associated with a major risk of sarcoidosis.

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Interpopulation effect of ACE I/D polymorphism on serum concentration of ACE in diagnosis of sarcoidosis

Cited by 17 publications

References 9 publications

ACE gene I/D polymorphism and risk of sarcoidosis development in Turkish patients

ACE gene I/D polymorphism and risk of sarcoidosis development in Turkish patients

Role of genetic polymorphisms in ACE and TNF-α gene in sarcoidosis: a meta-analysis

Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk

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