Interpregnancy weight change and adverse pregnancy outcomes: a systematic review and meta-analysis

Oteng‐Ntim, Eugene; Mononen, Sofia; Sawicki, Olga A.; Seed, Paul; Bick, Debra; Poston, Lucilla

doi:10.1136/bmjopen-2017-018778

Cited by 59 publications

(89 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, given the limitations of this initial study, additional, larger studies are needed to confirm the association with IPC‐BMI and ultimately to establish (or refute) a causal relationship between spina bifida and maternal BMI. While studies of IPC‐BMI are relatively new, and the best approaches for assessing this variable are still evolving (Benjamin et al, ; Oteng‐Ntim et al, ), additional studies of IPC‐BMI and spina bifida are strongly warranted, since maternal pre‐pregnancy BMI is a potentially modifiable risk factor that could serve as a target for spina bifida prevention efforts.…”

Section: Discussionmentioning

confidence: 99%

“…IPC-BMI, assessed based on linked records (e.g., birth certificates from successive pregnancies), has now been evaluated in studies of several BMI-related pregnancy outcomes, including birth defects (e.g., Benjamin et al, 2019;Bogaerts et al, 2013;McBain, Dekker, Clifton, Mol, & Grzeskowiak, 2016;Oteng-Ntim et al, 2018;Riley et al, 2016;Villamor, Sparen, & Cnattingius, 2008;Wallace, Bhattacharya, & Horgan, 2017). However, to our knowledge, an association between IPC-BMI and spina bifida has not been investigated.…”

Section: )mentioning

confidence: 99%

See 1 more Smart Citation

Association of interpregnancy change in body mass index and spina bifida

Benjamin

Ethen

Canfield

et al. 2019

Birth Defects Research

View full text Add to dashboard Cite

Background Epidemiologic studies have consistently identified an association between spina bifida and maternal body mass index (BMI). Whether this reflects a causal relationship is unknown. If this association does reflect a causal relationship, the risk of spina bifida should change with changes in maternal BMI. We evaluated the association between spina bifida and maternal change in BMI, assessed using interpregnancy change in BMI (IPC‐BMI). Methods We used data from the Texas Birth Defects Registry and statewide vital records for 248 spina bifida cases and 2,562 controls (2006–2012) to conduct a case–control study. We used logistic regression to estimate the association between IPC‐BMI and spina bifida, with adjustment for potential confounders. Results When assessed as a continuous variable, IPC‐BMI was associated with spina bifida, with a 5% increase in the odds of spina bifida per unit (approximately 6 pounds) increase in BMI (adjusted odds ratios [aOR] = 1.05, 95% CI: 1.02, 1.09). When assessed as a categorical variable, with weight stable women as the referent, the odds of spina bifida were lower in women with any BMI decrease (aOR = 0.73, 95% CI: 0.50, 1.08) and higher in women with an increase of ≥1 BMI units (aOR = 1.17, 95% CI: 0.85, 1.62). Conclusions Our findings provide suggestive, although not conclusive, evidence that maternal prepregnancy change in BMI, assessed using IPC‐BMI, is associated with spina bifida in the later pregnancy. Additional studies aimed at confirming this association and further strengthening the evidence for a causal relationship between spina bifida and maternal BMI are needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: )mentioning

confidence: 99%

Association of interpregnancy change in body mass index and spina bifida

Benjamin

Ethen

Canfield

et al. 2019

Birth Defects Research

View full text Add to dashboard Cite

show abstract

“…According to these new criteria, worldwide prevalence is 18%, ranging from 9 to 25% depending on the population studied [ 3 ]. High pre-pregnancy body mass index (BMI) is a major risk factor for GDM [ 4 ], and for this reason the obesity epidemic has spurred a parallel increase in the frequency of GDM. In North America, the rise in obesity was highest among women of reproductive age [ 5 ], with current rates at 30% in vulnerable populations [ 6 ].…”

Section: Prevalence and Pathophysiologymentioning

confidence: 99%

Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies

Sallam

Palmgren

Singh

et al. 2018

IJMS

View full text Add to dashboard Cite

With the rising global tide of obesity, gestational diabetes mellitus (GDM) burgeoned into one of the most common antenatal disorders worldwide. Macrosomic babies born to diabetic mothers are more likely to develop risk factors for cardiovascular disease (CVD) before they reach adulthood. Rodent studies in offspring born to hyperglycemic pregnancies show vascular dysfunction characterized by impaired nitric oxide (NO)-mediated vasodilation and increased production of contractile prostanoids by cyclooxygenase 2 (COX-2). Vascular dysfunction is a key pathogenic event in the progression of diabetes-related vascular disease, primarily attributable to glucotoxicity. Therefore, glucose-induced vascular injury may stem directly from the hyperglycemic intrauterine environment of GDM pregnancy, as evinced by studies showing endothelial activation and inflammation at birth or in childhood in offspring born to GDM mothers. This review discusses potential mechanisms by which intrauterine hyperglycemia programs dysfunction in the developing vasculature.

show abstract

“…Eine kürzlich veröffentlichte Metaanalyse [11] fand Belege für ein höheres Risiko für Entwicklungsstörungen sowie für Verhaltens-und emotionale Störungen bei Kindern von Müttern mit Adipositas. Eine exzessive Gewichtszunahme in der Schwangerschaft in Verbindung mit einer hohen Gewichtsretention nach der Geburt geht zudem mit einem erhöhten Risiko für Schwangerschafts-und Geburtskomplikationen in nachfolgenden Schwanger-schaften [12,13] sowie für Adipositas der Mutter im späteren Lebensalter [14] einher.…”

Section: Introductionunclassified

Exzessive Gewichtszunahme und Adipositas in der Schwangerschaft: Zusammenhänge zur psychischen Gesundheit der Mutter nach der Entbindung

Nagl

Lehnig

Stepan

et al. 2019

Adipositas - Ursachen, Folgeerkrankungen, Therapie

View full text Add to dashboard Cite

Zusammenfassung Ziel der Studie Adipositas, eine exzessive Gewichtszunahme und psychische Belastungen während der Schwangerschaft sind mit erheblichen gesundheitlichen Risiken für die Mutter und das ungeborene Kind verbunden. Ziel der Studie war die Erfassung der Prävalenz von Adipositas und einer exzessiven Gewichtszunahme sowie von Zusammenhängen zur psychischen Gesundheit der Mutter nach der Entbindung. Methodik In die Studie eingeschlossen wurden 774 Frauen im Alter zwischen 18 und 43 Jahren. Die postpartale psychische Gesundheit wurde mithilfe des BDI-II und der SCL-90-R erfasst. Ergebnisse 47,3 % der Frauen wiesen eine exzessive Gewichtszunahme auf. Die Prävalenz von Übergewicht und Adipositas betrug 15,4 % bzw. 7,6 %. Übergewicht und Adipositas waren relativ zum Normalgewicht mit einem höheren Risiko für eine exzessive Gewichtszunahme assoziiert (2,92 ≤ OR ≤ 3,75; p < 0,001; p = 0,008). Eine exzessive Gewichtszunahme war mit einem höheren Risiko für Makrosomie assoziiert (OR = 2,06; 95 % CI: 1,21–3,50). Für Adipositas zeigte sich eine Tendenz für ein erhöhtes Risiko für eine klinisch relevante postpartale depressive Symptomatik (OR = 2,16; 95 % CI: 0,99–4,69; p = 0,052). Schlussfolgerung Adipositas und exzessive Gewichtszunahme in der Schwangerschaft stellen auch in unserer Stichprobe ein häufiges und ernstzunehmendes Problem dar. Die Ergebnisse verdeutlichen die Notwendigkeit effektiver Präventionsprogramme sowie der Berücksichtigung der mütterlichen psychischen Gesundheit.

show abstract

Interpregnancy weight change and adverse pregnancy outcomes: a systematic review and meta-analysis

Cited by 59 publications

References 44 publications

Association of interpregnancy change in body mass index and spina bifida

Association of interpregnancy change in body mass index and spina bifida

Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies

Exzessive Gewichtszunahme und Adipositas in der Schwangerschaft: Zusammenhänge zur psychischen Gesundheit der Mutter nach der Entbindung

Contact Info

Product

Resources

About