This paper presents an interoperability of annual tile-based mosaic (MTB) images, as well as a verification of the validity of the model for the time series land cover analysis purposes. The primary data used are MTB image of Landsat-8 of the central part of Sumatra, acquired from January 2015 to June 2017. The method used for the interoperability validation is the digital analysis of three-years time series land cover. The classification was performed with four band spectral groups. Training samples are taken from the image of 2016. The results are then reclassified to improve the overall accuracy score based on Jefferies Matusita (JM) distance. The interoperability can be measured by the average of overall accuracy (AOA) score, namely Good (scores > 80%), Fair (70.0% -79.9%), and Bad (< 70%). The results show that the use of the groups Bands 6-5-4-3-2 performs the consistent accuracy level of Good with an AOA score of 86% for six classes object. Whereas the use of the groups Bands 6-5-4-3-2, Bands 6-5-4, and Bands 6-5 shows the consistent accuracy level of Good up to four classes object with an AOA score of 89%, 82%, and 81%, respectively. It means that the annual mosaic image of MTB model is accepted for the image interoperability with an AOA score of > 80% for six and four classes object. Thus the most efficient for interoperability is the use of Bands 6-5 to analyze four class object of land cover.