Interpretation of Creatinine Clearance

Elseviers, MM; Ga, Verpooten; Broe, M De; Debacker, GuyG.

doi:10.1016/s0140-6736(87)90167-x

Cited by 37 publications

(14 citation statements)

References 5 publications

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“…Since the bioavailability of ofloxacin in young subjects is >95% (Lode et al, 1987), the decrease in clearance is thought to be caused by reduced renal clearance. Calculated creatinine clearances may be decreased with aging between 25-75 years old (Elseviers et al, 1987) and there is a good linear relationship between renal ofloxacin clearance and estimated creatinine clearance in healthy elderly subjects. Thus, agerelated decreased clearance of ofloxacin in humans reflects creatinine clearance.…”

Section: Discussionmentioning

confidence: 99%

Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs

et al. 2014

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1. The pharmacokinetics of acetaminophen (marker of gastric emptying), antipyrine (marker of hepatic metabolic activity and total body water), diazepam (lipophilic and highly distributed), diphenhydramine (hepatic blood flow-limited and alpha-1 acid glycoprotein bound) and ofloxacin (renally eliminated) were evaluated in cynomolgus monkeys (3-18 years old) and beagle dogs (2-11 years old) as models in elderly persons. 2. Gastric pH fluctuated with aging in monkeys and dogs. The concentration of alpha-1 acid glycoprotein appeared to be increased by aging. There were no age-related differences in the absorption rates of the drugs under the conditions used in the study. Total body fat increased and water decreased in monkeys, but these parameters did not change in dogs. 3. Hepatic blood flow decreased in both species, but a significant decrease of hepatic clearance was only seen in monkeys. Renal clearance decreased significantly with age in monkeys and showed a tendency to decrease in dogs. 4. Age-related alterations of physiological parameters in monkeys are in agreement with clinical observations in humans, except for the lack of a change in the plasma albumin concentration. Therefore, this study suggests that monkey might be a suitable animal model for prediction of age-related changes in pharmacokinetics in humans.

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Section: Discussionmentioning

confidence: 99%

Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs

et al. 2014

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“…Creatinine clearance (Ccr) was estimated according to the formula of Cockcroft and Gault [10]. The Ccr percentile rank according to sex and age was also determined [11]. Fractional sodium excretion (normal values <1%) and percentage of tubular phosphate reabsorption (normal values >84%) were calculated using the standard formulae.…”

Section: Methodsmentioning

confidence: 99%

Detection of Renal Dysfunctions in Family Members of Patients with Balkan Endemic Nephropathy

et al. 2005

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Background/Aim: Recent studies have questioned whether new cases of Balkan endemic nephropathy (BEN) are occurring. The aim of the present study was to find out whether new members with renal dysfunctions can be identified among family members of BEN patients from the Kolubara region. Methods: The study included 47 family members of 5 BEN patients on hemodialysis (HD) and 17 members of 3 non-BEN patients on HD. Their medical and epidemiological histories were taken, an objective survey made, and all persons were examined for global and tubular kidney function. Results: Seven BEN family members (2 with previously known BEN) had creatinine clearance (Ccr) below the 75th percentile rank according to sex and age. All non-BEN family members had normal Ccr and no evidence of previous renal disorders. Hypertension was found in 20 (43%) BEN and 6 (35%) non-BEN family members. No significant differences in the frequency of renal function disorders (proteinuria, α₁-microglobulinuria, urine specific gravity, osmolality, functional excretion of sodium, tubular phosphate resorption) or anemia were found between the groups. Renal disorders were detected in 18 BEN family members without previously detected disease, 3 of whom fulfilled criteria for a diagnosis of BEN and another 2 for BEN-suspected persons. Conclusion: New cases of BEN are still arising among the affected families in the Kolubara region.

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“…On average, patients showing the analytical interference due to contrast media were 60 ± 10 years old. As paraproteinemia mainly occurs in the older age groups , where renal elimination rate of contrast media is often lower due to renal insufficiency , the problem is most commonly encountered in the elderly.…”

Section: Discussionmentioning

confidence: 99%

Dual‐wavelength recording, a simple algorithm to eliminate interferences due to UV‐absorbing substances in capillary electrophoresis

et al. 2014

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Analytical interferences have been described due to the presence of various exogenous UV-absorbing substances in serum. Iodine-based X-ray contrast agents and various antibiotics have been reported to interfere with interpretation of serum protein pherograms, resulting in false diagnosis of paraproteinemia. In the present study, we have explored the possibility of measuring UV absorbance at two distinct wavelengths (210 and 246 nm) to distinguish between true and false paraproteins on a Helena V8 clinical electrophoresis instrument. This study demonstrates that most substances potentially interfering with serum protein electrophoresis show UV-absorption spectra that are distinct from those of serum proteins. Scanning at 246 nm allows detection of all described interfering agents. Comparing pherograms recorded at both wavelengths (210 and 246 nm) enables to distinguish paraproteins from UV-absorbing substances. In case of a true paraprotein, the peak with an electrophoretic mobility in the gamma-region decreases, whereas the X-ray contrast media and antibiotics show an increased absorption when compared to the basic setting (210 nm). The finding of iodine-containing contrast media interfering with serum protein electrophoresis is not uncommon. In a clinical series, interference induced by contrast media was reported in 54 cases (of 13 237 analyses), corresponding with a prevalence of 0.4%. In the same series, 1631 true paraproteins (12.3%) were detected. Implementation of the proposed algorithm may significantly improve the interpretation of routine electrophoresis results. However, attention should still be paid to possible interference due to presence of atypical proteins fractions (e.g., tumor markers, C3).

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Interpretation of Creatinine Clearance

Cited by 37 publications

References 5 publications

Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs

Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs

Detection of Renal Dysfunctions in Family Members of Patients with Balkan Endemic Nephropathy

Dual‐wavelength recording, a simple algorithm to eliminate interferences due to UV‐absorbing substances in capillary electrophoresis

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