Interpretation of Magnetization Transfer and Proton Cross-Relaxation Spectra of Biological Tissues

Tessier, Jean; Dillon, N.; Carpenter, T. Adrian; Hall, L. D.

doi:10.1006/jmrb.1995.1069

Cited by 36 publications

(37 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the MT effects of the other samples increase with increasing concentration of agarose. Furthermore, smaller MT effects are observed in the samples doped with MnCl 2 because of their shorter T 1 values [18]. Above all, these results prove an excellent agreement (within 3%) between the measurements collected by the FFC-MTC and the RF-MTC methods.…”

Section: Resultssupporting

confidence: 73%

Off-resonance magnetisation transfer contrast (MTC) MRI using fast field-cycling (FFC)

Choi¹,

Davies²,

Lurie³

2010

Journal of Magnetic Resonance

View full text Add to dashboard Cite

Magnetisation transfer contrast (MTC) is an important MR contrast generating mechanism to characterise the undetectable bound protons indirectly using the decreased signal intensity of the observable free protons. MTC imaging typically employs a range of off-resonance RF pre-saturation pulse with maintaining the RF magnetic field (B(1)) at a specified value. However, this presents a technical difficulty, particularly at low field, because the larger offset frequencies tend to be outside the bandwidth of the RF transmit system, causing B(1) to vary with the frequency offset. Here, we demonstrate a novel off-resonance irradiation method using fast field-cycling which allows switching of the external magnetic field between several chosen strengths, while holding constant the RF frequency and B(1) level. This permits one to avoid the problem of B(1) variation as a function of frequency offset. The results obtained by this new technique are in excellent agreement with those obtained by the conventional technique.

show abstract

Section: Resultssupporting

confidence: 73%

Off-resonance magnetisation transfer contrast (MTC) MRI using fast field-cycling (FFC)

Choi¹,

Davies²,

Lurie³

2010

Journal of Magnetic Resonance

View full text Add to dashboard Cite

show abstract

“…It is similar in concept to the three-pool models developed by Tessier (19) for describing multipool MT and Woessner who studied PARACEST agents with multiple labile groups (20). Although some cases necessitate the inclusion of more than one MT pool (19,(21)(22)(23)), we chose here to limit the number of MT pools to one as it is sufficient to describe MT effects in agar (17). The framework of the model used in this article is illustrated in Fig.…”

Section: Theorymentioning

confidence: 99%

Understanding quantitative pulsed CEST in the presence of MT

Desmond

Stanisz

2011

Magnetic Resonance in Med

134

View full text Add to dashboard Cite

Phantom experiments in agar and ammonium chloride were performed to evaluate a three-pool model of magnetization transfer and chemical exchange saturation transfer (CEST) in a pulsed saturation transfer experiment. The utility of the pulsed CEST method was demonstrated by varying the pH of the phantoms and observing the effect upon the CEST spectra both with and without the solid agar (the magnetization transfer pool), while fitting the spectra to the Bloch equation model with exchange. Pulsed CEST could be used to robustly quantify parameters related to CEST, including the exchange rate constant describing proton exchange with free water and the concentration of exchanging protons. Furthermore, the exchange rate constant and the CEST pool offset frequency of the ammonium chloride remained unchanged in the presence of a magnetization transfer pool. The logarithm of the fitted exchange rate constant was linearly related to pH: this relationship was maintained in the presence of magnetization transfer. Magn Reson Med 67:979-990,

show abstract

“…It has been shown that GC is due to collagen 1 H of restricted mobility [25], for which a Gaussian line shape is usually assumed [30,31]. The LLC signal, coming from 1 H with higher mobility, is due to the water and fat 1 H in the bone.…”

Section: Resultsmentioning

confidence: 99%

Analysis of 1H-NMR relaxation time distributions in L1 to L6 rat lumbar vertebrae

Fantazzini¹,

Garavaglia²,

Palombarini³

et al. 2004

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Interpretation of Magnetization Transfer and Proton Cross-Relaxation Spectra of Biological Tissues

Cited by 36 publications

References 0 publications

Off-resonance magnetisation transfer contrast (MTC) MRI using fast field-cycling (FFC)

Off-resonance magnetisation transfer contrast (MTC) MRI using fast field-cycling (FFC)

Understanding quantitative pulsed CEST in the presence of MT

Analysis of 1H-NMR relaxation time distributions in L1 to L6 rat lumbar vertebrae

Contact Info

Product

Resources

About