Interpretation of the Normal<sup>99m</sup>Tc Polyphosphate Rectilinear Bone Scan

Nd, Charkes; Valentine, G. H.; Cravitz, B

doi:10.1148/107.3.563

Cited by 26 publications

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“…Bone scintigraphy is a highly sensitive indicator of focal and generalized skeletal disorders [8] and reflects the osseous metabolic turnover [27,30], The mechanism of the accumulation of Tc-PP in the bones is still controversial [4.15,16,27], but may be a function of the regional blood flow [16,27] or may be caused by affinity of Tc-PP to the nonosteoid organic matrix, as in patients with secondary HPT [27], The method is superior to X-ray in early detection of skeletal changes [21]. It may reveal osteonecrotic lesions considerably earlier than X-ray [21], or may reveal changes that will never appear roentgenographically [27,30,31], The scintigraphic findings are unspecific and in order to secure the primary diagnosis of the bone lesion, the scintigram should be supplemented with clinical, roentgenological, histological or biochemical parameters.…”

Section: Discussionmentioning

confidence: 99%

“…The collimators used have a nearly depth-independent response over a range of 3-5 in; this prevents the errors in interpretation which may be caused by the 'tomographic' effect of a fine focus collimator, if the position of the patient is not strictly symmetrical [8].…”

Section: Scintigraphymentioning

confidence: 99%

“…Morphological evaluation of bone changes in uremia has mostly been per formed using X-ray examination [2,26,29], As bone scintigraphy may reveal metabolic skeletal changes before seen on X-ray [27] we have found it of interest to report the findings from an investigation with ""TC'-polyphosphate (Tc-PP) scintigraphy [8] in 30 uremic patients on regular hemodialysis.…”

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confidence: 99%

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Scintigraphic Skeletal Changes in Uremic Patients on Regular Hemodialysis

Ølgaard

Heerfordt

Madsen³

1976

Nephron

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⁹⁹Tc^m-polyphosphate (Tc-PP) bone scintigraphy was performed in 30 consecutive uremic patients on regular hemodialysis and compared with a normal control group. 27 of the patients (90%) had pathological accumulation on the scintigrams, while roentgenographic abnormalities were present in only 10 patients (33%), indicating that scintigraphy is superior to X-ray in the early detection of skeletal changes in uremic patients. In the group with the most pronounced uptake on the scintigrams there was a preponderance of previously kidney-transplanted patients, while no correlation could be demonstrated between the severity of the scintigraphic findings and the duration of the hemodialysis period, the anephric state of the patients, the underlying kidney disease or the sex. It is suggested that intensive glucocorticoid treatment, even of short duration in the previously kidney-transplanted patients, may aggravate uremic osteodystrophy.

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Section: Discussionmentioning

confidence: 99%

Section: Scintigraphymentioning

confidence: 99%

mentioning

confidence: 99%

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Scintigraphic Skeletal Changes in Uremic Patients on Regular Hemodialysis

Ølgaard

Heerfordt

Madsen³

1976

Nephron

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“…The abnormal scan rates recorded by other authors are listed in Table IV. Charkes et al (1973) warned that the heightened sensitivity and resolution obtainable with gsTcm phosphate scanning might well lead to errors in scan interpretation. For example, lSF scanning is capable of demonstraing only 56 per cent of lesions revealed by 99Tcm diphosphonate scanning (Silberstein et al, 1973).…”

Section: Incidence Of Abnormal Scansmentioning

confidence: 99%

The value of preliminary bone scanning in staging and assessing the prognosis of breast cancer

Campbell

Banks

Oates

1976

Journal of British Surgery

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Preliminary bone scans have been performed on all patients with early breast cancer. The incidence of positive scans has been recorded and several factors determining scan status have been enumerated. Particular attention has been focused on the natrual history of scan positive and scan negative patients. Eighteen per cent of stage I and 41 per cent of stage II cancers had positive bone scans. Scan results were correlated with age, menopausal status, tumour position, tumour size and histological node status. Postmenopausal patients were found to have a significantly increased risk of being scan positive (P less than 0-01). Follow-up studies have confirmed that the lesions demonstrated by scanning actually represent metastatic foci. At 18 months 85-7 per cent of scan positive patients had evidence of disseminated disease compared with only 11-4 per cent of scan negative patients (P less than 0-01). Clinically overt advanced disease evolves from positive scan lesions. It is clear that a significant percentage of patients felt to have early breast cancer already have widely disseminated disease at the initial presentation. The biological significance of bone scan lesions makes a sensitive screening test for dissemination an essential part of the preliminary assessment of patients with breast cancer. Bone scans provide an excellent prognostic index at a patient's initial assessment.

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“…Es ist bekannt, daß im normalen Tc-Sn-P-Knochenszintigramm z. B. die Region des kaudalen Scapulawinkels besonders deutlich zur Darstellung kommt (11), wobei nach der Erfahrung der Bereich der knöchernen Scapulastrukturen regelmäßig überschritten wird. Dies bedeutet eine erhöhte Anreicherung in den dort stark ausgeprägten Sehnenenansätzen und stimmt mit unseren Befunden einer hohen 99m Tc-Pyrophosphat-Konzentration in der Patellarsehne überein (Tab.…”

Section: Diskussionunclassified

Zur Frage der Weichteilkonzentration von 99mTc-Zinn-Phosphat-Komplexen

Lieven¹,

Leisner²,

Büll³

1975

Nuklearmedizin

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ZusammenfassungDie Konzentration von 99mTc-Pyrophosphat wurde in normalen, abakteriell und bakteriell veränderten Weichteilen von Kaninchen-Extremitäten sowie bei Coxarthrose in Gelenkkapsel und Muskulatur und auch in Kniegelenksergüssen bestimmt. Im Vergleich zur Konzentration von 85Sr, die als Maß für die Verkalkungstendenz angesehen werden kann, waren die Konzentrationen von 99mTc-Pyrophosphat in den Weichteilen bis 120 Min. p. i. niedriger, nach 24 Std. jedoch signifikant (bis zum Elffachen) höher. Dies spricht für eine Fixation von 99mTc-Pyrophosphat in kollagenhaltigen Geweben, also auch in den vorgestellten Weichteiltumoren (Myosarkom, Synovialiom, Mammakarzinom). Der Mechanismus verzögerter Äquilibration muß bei 99mTc-Pyrophosphat für die vermehrte Anreicherung in Lymphödem, Ascites und in Ergüssen bei aktivierten Gonarthrosen angenommen werden. Die Möglichkeit einer Abhängigkeit der Anreicherung von 99mTc-Pyrophosphat in Knochen und Weichteilen vom Kollagengehalt wird diskutiert.

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Interpretation of the Normal^99mTc Polyphosphate Rectilinear Bone Scan

Cited by 26 publications

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Scintigraphic Skeletal Changes in Uremic Patients on Regular Hemodialysis

Scintigraphic Skeletal Changes in Uremic Patients on Regular Hemodialysis

The value of preliminary bone scanning in staging and assessing the prognosis of breast cancer

Zur Frage der Weichteilkonzentration von 99mTc-Zinn-Phosphat-Komplexen

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Interpretation of the Normal99mTc Polyphosphate Rectilinear Bone Scan

Cited by 26 publications

References 0 publications

Scintigraphic Skeletal Changes in Uremic Patients on Regular Hemodialysis

Scintigraphic Skeletal Changes in Uremic Patients on Regular Hemodialysis

The value of preliminary bone scanning in staging and assessing the prognosis of breast cancer

Zur Frage der Weichteilkonzentration von 99mTc-Zinn-Phosphat-Komplexen

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Interpretation of the Normal^99mTc Polyphosphate Rectilinear Bone Scan