Interpretative reading of the antibiogram – a semi-naïve Bayesian approach

Andreassen, Steen; Zalounina, Alina; Sanden, Line Rugholm; Leibovici, Leonard

doi:10.1016/j.artmed.2015.08.004

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…Such MIC variation could be due to the particular characteristics of each clinical isolate, such as membrane composition, protease secretion, etc. [59] and has been also described for antimicrobial testings [60]. The acquired antimicrobial drug resistance attributed to the biofilm formation was also observed for the isolates studied here.…”

Section: Discussionsupporting

confidence: 63%

Antimicrobial and Antibiofilm Effects of Peptides from Venom of Social Wasp and Scorpion on Multidrug-Resistant Acinetobacter baumannii

Neves

Mortari

Schwartz

et al. 2019

Toxins

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Intravascular stent infection is a rare complication with a high morbidity and high mortality; bacteria from the hospital environment form biofilms and are often multidrug-resistant (MDR). Antimicrobial peptides (AMPs) have been considered as alternatives to bacterial infection treatment. We analyzed the formation of the bacterial biofilm on the vascular stents and also tested the inhibition of this biofilm by AMPs to be used as treatment or coating. Antimicrobial activity and antibiofilm were tested with wasp (Agelaia-MPI, Polybia-MPII, Polydim-I) and scorpion (Con10 and NDBP5.8) AMPs against Acinetobacter baumannii clinical strains. A. baumannii formed a biofilm on the vascular stent. Agelaia-MPI and Polybia-MPII inhibited biofilm formation with bacterial cell wall degradation. Coating biofilms with polyethylene glycol (PEG 400) and Agelaia-MPI reduced 90% of A. baumannii adhesion on stents. The wasp AMPs Agelaia-MPI and Polybia-MPII had better action against MDR A. baumannii adherence and biofilm formation on vascular stents, preventing its formation and treating mature biofilm when compared to the other tested peptides.

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Section: Discussionsupporting

confidence: 63%

Antimicrobial and Antibiofilm Effects of Peptides from Venom of Social Wasp and Scorpion on Multidrug-Resistant Acinetobacter baumannii

Neves

Mortari

Schwartz

et al. 2019

Toxins

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show abstract

“…Moreover, a recent randomized controlled trial on a WISCA antibiotic stewardship clinical decision support tool conducted in the US, found that providers in the intervention group followed recommendations to change antibiotics 60% of the time. [10] As previously noted in other studies, [11][12][13] there are still analytical challenges in the WISCA development, represented mainly by the paucity of data in the different strata in the models that can be overcome using Bayesian methods.…”

Section: Introductionmentioning

confidence: 92%

Development of a Weighted-Incidence Syndromic Combination Antibiogram (WISCA) to guide the choice of the empiric antibiotic treatment for urinary tract infection in paediatric patients: a Bayesian approach

Barbieri

Bottigliengo

Tellini

et al. 2021

Antimicrob Resist Infect Control

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Background To evaluate the ability of Weighted-Incidence Syndromic Combination Antibiograms (WISCA) to inform the selection of empirical antibiotic regimens for suspected paediatric community-acquired urinary tract infections. Methods Data were collected from outpatients (< 15 years) accessing the emergency rooms of Padua University-Hospital and Mestre Dell' Angelo-Hospital (Venice) between January 1st, 2016, and December 31st, 2018. WISCAs were developed by estimating the coverage of eight regimens using a Bayesian hierarchical model adjusted for age, sex, and previous antibiotic treatment or renal/urological comorbidities. Results 385 of 620 urine culture requests were included in the model analysis. The most frequently observed bacterium was E. coli (85% and 87%, Centre A and B). No centre effect on coverage estimates was found, and data were successfully pooled together. Coverage ranged from 77.8% (Co-trimoxazole) to 97.6% (Carbapenems). Complex cases and males had significantly lower odds of being covered by a regimen than non-complex cases and females (odds ratio (OR) 0.49 [95% HDI, 0.38–0.65], and OR: 0.73 [95% HDIs, 0.56–0.96] respectively). Children aged 3–5 years had lower odds of being covered by a regimen than other age groups, except for neonates. Conclusions The developed WISCAs provide highly informative estimates on coverage patterns overcoming the limitation of combination antibiograms and expanding the framework of previous Bayesian WISCA algorithm.

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“…‘Interpretative reading’ is a core methodology employed by clinicians and involves analysing the susceptibility pattern of a given organism, not just the results of individual antibiotics. 13 , 14 , 31 Commercially available automated test systems employ different variations of what are known as ‘expert test systems’. These systems are computers that use data to simulate human decision-making and use facts to infer what is already known.…”

Section: Step 1 Collaborate With the Clinical Microbiology Laboratory...mentioning

confidence: 99%

#AMRrounds: a systematic educational approach for navigating bench to bedside antimicrobial resistance

Liu,

Prinzi,

Borjan

et al. 2023

JAC-Antimicrobial Resistance

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Antimicrobial resistance (AMR) continues to serve as a major global health crisis. Clinicians practising in this modern era are faced with ongoing challenges in the therapeutic management of patients suffering from antimicrobial-resistant infections. A strong educational understanding and synergistic application of clinical microbiology, infectious disease and pharmacological concepts can assist the adventuring clinician in the navigation of such cases. Important items include mobilizing laboratory testing for pathogen identification and susceptibility data, harnessing an understanding of intrinsic pathogen resistance, acknowledging epidemiological resistance trends, recognizing acquired AMR mechanisms, and consolidating these considerations when constructing an ideal pharmacological plan. In this article, we outline a novel framework by which to systematically approach clinical AMR, encourage AMR-related education and optimize therapeutic decision-making in AMR-related illnesses.

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Interpretative reading of the antibiogram – a semi-naïve Bayesian approach

Cited by 9 publications

References 7 publications

Antimicrobial and Antibiofilm Effects of Peptides from Venom of Social Wasp and Scorpion on Multidrug-Resistant Acinetobacter baumannii

Antimicrobial and Antibiofilm Effects of Peptides from Venom of Social Wasp and Scorpion on Multidrug-Resistant Acinetobacter baumannii

Development of a Weighted-Incidence Syndromic Combination Antibiogram (WISCA) to guide the choice of the empiric antibiotic treatment for urinary tract infection in paediatric patients: a Bayesian approach

#AMRrounds: a systematic educational approach for navigating bench to bedside antimicrobial resistance

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