Interpreting Cancer Biology: Refining Our Therapeutic Algorithm in Breast Cancer

Hortobágyi, Gabriel N.; Conte, Pierfranco

doi:10.1634/theoncologist.2013-0117

Cited by 1 publication

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using the SEER * Stat survival session (Ederer II actuarial method) [ 3 , 7 ], 3-year relative survival rates (RSR) were adjusted (by age, gender, and race) for expected mortality in the general US population; 100% RSR indicates no survival disadvantage in patients versus the general population [ 3 ]. With follow-up on vital status through the end of 2011 [ 7 ], the 3-year RSR included diagnoses through 2008.…”

Section: Methodsmentioning

confidence: 99%

“… a SEER summary stage 2000 (see text) [ 3 , 7 , 8 ]. b Number of cases at start of follow-up, after exclusion of those with breast cancer as other than their first or only reportable tumor in the SEER database, and breast cancers ascertained by death certificate or autopsy only (see text).…”

Section: Figurementioning

confidence: 99%

“…A statistically significant increase (1976–2009) has been reported in the age-standardized incidence rate (ASIR) for distant stage breast cancer diagnosed in women at age 25–39 years in the population covered by population-based cancer registries of the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program [ 1 ]. The report raised concerns regarding increasing rates of aggressive breast cancer in young women [ 2 , 3 ], especially because the increases were largest for age 25–39 years in the most recent time period examined (i.e., 2000–09) with a slight increase also at age 40–54 years [ 1 ]. Support for stage migration as an explanation for the long-term trends was regarded as limited [ 1 ], and the increase in distant stage incidence in young women is unexplained [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Increase in Distant Stage Breast Cancer Incidence Rates in US Women Aged 25–49 Years, 2000–2011: The Stage Migration Hypothesis

Polednak¹

2015

Journal of Cancer Epidemiology

View full text Add to dashboard Cite

Background. Unexplained increases have been reported in incidence rates for breast cancer diagnosed at distant stage in younger U.S. women, using data from the Surveillance, Epidemiology and End Results (SEER) Program. Methods. This report focused on recent SEER trends (2000–2011) in age-standardized incidence rates of invasive breast cancer at ages 25–39 and 40–49 years and the hypothesis that stage migration may have resulted from advances in detecting distant metastases at diagnosis. Results. Increases in the rates for distant stage were roughly equal to decreases in the rates for the most advanced stage subgroups within regional stage; this was evident for estrogen receptor (ER) negative cancers, associated with poorer prognosis, but not for ER positive cancers. The 3-year relative survival rate increased over time for distant stage (especially in the ER positive subgroup) and regional stage but not for localized stage; these trends do not contradict the stage-migration hypothesis. Conclusions. Findings provide some support for stage migration as one explanation for the recent increase in incidence of distant stage breast cancer, but additional studies are needed using other databases.

show abstract

Section: Methodsmentioning

confidence: 99%