Interpretive criteria for disk diffusion tests using 5-microgram cefdinir disks with rapidly growing clinical isolates

Jones, Ronald N.; Erwin, Meridith E.; Gooding, B. Briggs

doi:10.1128/jcm.30.4.1022-1023.1992

Cited by 12 publications

(3 citation statements)

References 7 publications

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“…In contrast, enterococcal species other than E. faecalis rarely demonstrated an increased susceptibility to cephalosporins when tested on a bloodcontaining medium. Data presented here also indicate that the 7-alpha hydroxyimino-substituted cephalosporins (cefdaloxime and cefdinir) will also have enhanced activities against enterococci when blood products are added to the test medium (3,5).…”

mentioning

confidence: 53%

“…These cephalosporin disks were applied to the surfaces of two different media (a single MH agar lot with and without 5% sheep blood; Remel Laboratories, Lenexa, Kans.) and tested (9) against 57 strains of enterococci that included the following organisms: 30 strains of E. faecalis, including ATCC 29212, 10 strains of Enterococcus faecium (5 of which were ampicillin resistant), 5 strains of Enterococcus gallinarum, 5 strains of Enterococcus raffinosus, 5 strains of Enterococcus hirae, and 2 strains of Enterococcus durans. These organisms were generally clinical strains isolated from blood or sterile body fluids of patients at the University of Iowa Hospitals and Clinics (Iowa City).…”

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confidence: 99%

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Effects of blood medium supplements on activities of newer cephalosporins tested against enterococci

1994

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This comparative study determined the effect of blood on the antienterococcal activities of the newer cephalosporins. Standardized disk diffusion susceptibility tests were performed with 57 strains of enterococci (30 Enterococcusfaecalis strains) on Mueller-Hinton agar with and without 5% sheep blood supplementation. Twelve cephalosporins representing five different structural groups (based on the 7-alpha position substitution) were tested. The greatest frequency of activity enhancement by blood was observed with cefdaloxime and cefdinir (7-alpha hydroxyimino group) against E. faecalis. Cephalosporins with a 7-alpha methoxyimino group (cefpodoxime, cefepime, and cefpirome) had marked increases in zone diameters (3 to >9 mm) when tested with the blood supplement. Cephems with 7-alpha amino or carboxy substitutions did not demonstrate any enhanced activity. Awareness of this phenomenon is important for the interpretation and accuracy of cephalosporin susceptibility testing.

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confidence: 53%

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confidence: 99%

Effects of blood medium supplements on activities of newer cephalosporins tested against enterococci

1994

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“…Cefaclor was tested by microdilution methods only. For disk-agar diffusion, susceptibility was defined as a zone diameter of Ն20 mm, intermediate susceptibility was defined as a zone diameter of 17 to 19 mm, and resistance was defined as a zone diameter of Յ16 mm (18). For cefdinir testing by the microdi-lution methodology, susceptibility was defined as an MIC of Յ1 g/ml, intermediate susceptibility was defined as an MIC of 2 g/ml, and resistance was defined as an MIC of Ն4 g/ml.…”

Section: Methodsmentioning

confidence: 99%

Comparison of cefdinir and cefaclor in treatment of community-acquired pneumonia

Drehobl¹,

Bianchi²,

Keyserling³

et al. 1997

Antimicrob Agents Chemother

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Six hundred ninety patients were enrolled in a multicenter, randomized, double-blind trial comparing the efficacy and safety of cefdinir with those of cefaclor in the treatment of community-acquired pneumonia. Patients received either 10 days of treatment with cefdinir (n ‫؍‬ 347) at 300 mg twice daily or 10 days of treatment with cefaclor (n ‫؍‬ 343) at 500 mg three times daily. Microbiological assessments were performed on sputum specimens obtained at admission and at the two posttherapy visits, if available. Respiratory tract pathogens were isolated from 538 (78%) of 690 patient admission sputum specimens, with the predominant pathogens being Haemophilus parainfluenzae, Haemophilus influenzae, Streptococcus pneumoniae, and Staphylococcus aureus. The microbiological eradication rates at the test-of-cure visit were 92% (238 of 260 pathogens) and 93% (245 of 264 pathogens) for the evaluable patients treated with cefdinir and cefaclor, respectively. A satisfactory clinical response (cure plus improvement) was achieved in 89% (166 of 187) and 86% (160 of 186) of the evaluable patients treated with cefdinir and cefaclor, respectively. Except for the incidence of diarrhea, adverse event rates while on treatment were equivalent between the two treatment groups. Diarrhea incidence during therapy was higher for patients treated with cefdinir (13.7%) than for patients treated with cefaclor (5.3%). These results indicate that cefdinir is effective and safe in the treatment of patients with pneumonia.

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Susceptibility testing interpretive criteria and drug stability for cefdinir, cefetamet, and cefpodoxime against Neisseria gonorrhoeae

Barrett

Jones

1992

Diagnostic Microbiology and Infectious Disease

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Interpretive criteria for disk diffusion tests using 5-microgram cefdinir disks with rapidly growing clinical isolates

Cited by 12 publications

References 7 publications

Effects of blood medium supplements on activities of newer cephalosporins tested against enterococci

Effects of blood medium supplements on activities of newer cephalosporins tested against enterococci

Comparison of cefdinir and cefaclor in treatment of community-acquired pneumonia

Susceptibility testing interpretive criteria and drug stability for cefdinir, cefetamet, and cefpodoxime against Neisseria gonorrhoeae

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