Interrelation of inflammation and oxidative stress in liver cirrhosis

Pomacu, Mihnea Marian; Trașcă, Maria Diana; Pădureanu, Vlad; Buga, Ana-Maria; Andrei, Ana Marina; Stănciulescu, Elena Camelia; Baniţă, Ileana Monica; Rădulescu, D; Pisoschi, Cătălina Gabriela

doi:10.3892/etm.2021.10034

Cited by 32 publications

(22 citation statements)

References 45 publications

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“…Many experimental studies have reported that excessive production of ROS in liver damage causes excessive production of proinflammatory cytokines in cells ( Pizzino et al, 2017 ; Pomacu et al, 2021 ). MAPK and NF-κB signaling pathways are activated when cellular stress and ROS production increase ( Hong et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

et al. 2023

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Background: Acrylamide causes hepatotoxicity with the effect of oxidative stress and inflammatory processes. Carvacrol is a monoterpenic phenol with antioxidant and anti-inflammatory properties.Aims: To determine the effects of carvacrol on oxidative liver injury induced by acrylamide administration in rats.Methods: Rats were divided into three groups of six animals each: healthy group acrylamide group (ACR), and acrylamide + carvacrol group (TACR). First, carvacrol (50 mg/kg) was administered intraperitoneally to the CACR group. One hour later, acrylamide (20 mg/kg) was given orally to the ACR and CACR groups. This procedure was performed for 30 days, after which the animals were sacrificed. The malondialdehyde (MDA) and total glutathione (tGSH) levels, total oxidant (TOS) and total antioxidant status (TAS), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and nuclear factor kappa b (NF-κB) were measured in the excised liver tissues. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in blood serum samples. Liver tissues were also examined histopathologically.Results: In the ACR group, malondialdehyde, TOS, ALT, AST levels, and NF-κB, IL-1β, and TNF-α levels were found to be high, and tGSH and total antioxidant status levels were low. In addition, diffuse degenerative changes and necrosis in hepatocytes, and moderate inflammation in the portal region were detected in the liver tissues of the ACR group. While carvacrol prevented the biochemical changes induced by acrylamide, it also alleviated the damage in the histological structure.Conclusion: Carvacrol may be used for liver damage caused by acrylamide.

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Section: Discussionmentioning

confidence: 99%

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

et al. 2023

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“…It has also been suggested that triglycerides play a key role in HSCs activation [ 17 ]. The role of oxidative stress has been reported in various types of liver disease, liver fibrosis, and cirrhosis [ 18 ]. When various etiologies lead to an imbalance between oxidation and antioxidants, both free radicals and oxidative stress products can activate HSCs and eventually lead to liver fibrosis [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics Analysis of Common Genetic and Molecular Traits and Association of Portal Hypertension with Pulmonary Hypertension

Chen

2022

Journal of Healthcare Engineering

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Portal hypertension (PH) is an important cause of pulmonary arterial hypertension(PAH), but its mechanism is still unclear. We used genetic data analysis to explore the shared genes and molecular mechanisms of PH and PAH. We downloaded the PH and PAH data from the GEO database, and used the weighted gene coexpression network analysis method (WGCNA) to analyze the coexpression modules of idiopathic noncirrhotic portal hypertension (INCPH) and cirrhotic portal hypertension (CPH) and pulmonary hypertension, respectively. Enrichment analysis was performed on the common genes, and differential gene expressions (DEGs) were used for verification. The target genes of INCPH and PAH were obtained by string and cytoscape software, and the miRNAs of target genes were predicted by miRwalk, miRDB, and TargetScan and their biological functions were analyzed; finally, we used PanglaoDB to predict the expression of target genes in cells. In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were “P53 signaling pathway,” “synthesis of neutral lipids”; PAH and INCPH are “terminal,” “Maintenance Regulation of Granules,” and “Toxin Transport.” DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for “P53 signaling pathway,” “TGF-β signaling pathway,” “TNF signaling pathway,” and “fatty acid metabolism,” and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc. In conclusion, the mechanism of pulmonary hypertension induced by portal hypertension may be related to telomere dysfunction and P53 overactivation, and lipid metabolism and intestinal inflammation are also involved in this process.

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“…Involvement of oxidative stress in patients with liver diseases has been investigated. The impact of both ROS and RNS in the liver diseases pathogenesis has been reported (Pomacu et al, 2021). Savu et al, (2012) demonstrated that, plasma TAC was elevated; despite the high levels of oxidative stress, in patients with uncomplicated type2 diabetes compared to that of the control subjects.…”

Section: Pomacu Et Al (2021)mentioning

confidence: 97%

Antioxidants-based scores to predict Hepatocellular Carcinoma Patients among Chronic Hepatitis C individuals: correlation with Non-invasive Markers of Hepatic Fibrosis

Toson¹,

Shiha²,

Elfar³

2022

Scientific Journal for Damietta Faculty of Science

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Background High prevalence of Hepatitis C virus (HCV) in Egypt considers it as the major cause of hepatocellular carcinoma (HCC). So, several attempts have been used to predict HCC but still need more. In this regard, the predicting abilities of superoxide dismutase (SOD) and catalase (CAT) activities as well as total antioxidant capacity (TAC) were tested for estimating chronic hepatitis C (CHC)-mediated HCC. Patients and methods Blood samples from 79 patients (23 CHC and 56 HCC) were withdrawn to estimate these antioxidants and the routine analysis markers. Beside 15 healthy volunteers were included Results The medians of SOD activity and TAC values were significantly elevated in sera of HCC patients with positive correlation (P<0.0001, r=0.334) when compared with those of either CHC or healthy controls (P<0.0001). On contrary, the median of CAT activity was significantly lowered (P<0.0001) with negative correlation with SOD activity (r=-0.146, P<0.04).Stepwise logistic regression analysis of the last three markers produced a score; named "Antioxidants-diagnostic" which increased the AUCs values and their diagnostic activities (P<0.0001). By combining the three marker values with that of Age-platelet index (API) produced a score named "Antioxidants-API". Also, by combining them with that of the routine analysis values produced a score named "AAI-antioxidants". In each case the AUCs values were enhanced when compared with those of its native antioxidants (P<0.0001). Conclusion The assessment of these antioxidant activities and their combination in the last three scores can enhance their activities to more precisely predict HCC patients among CHC ones and control individuals.

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Interrelation of inflammation and oxidative stress in liver cirrhosis

Cited by 32 publications

References 45 publications

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

Bioinformatics Analysis of Common Genetic and Molecular Traits and Association of Portal Hypertension with Pulmonary Hypertension

Antioxidants-based scores to predict Hepatocellular Carcinoma Patients among Chronic Hepatitis C individuals: correlation with Non-invasive Markers of Hepatic Fibrosis

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