Interrelations between fat distribution, muscle lipid content, adipocytokines, and insulin resistance: effect of moderate weight loss in older women

Mazzali, Gloria; Francesco, Vincenzo Di; Zoico, Elena; Fantin, Francesco; Zamboni, Giulia; Benati, Claudia; Bambara, Valentina; Negri, M; Bosello, O; Zamboni, Mauro

doi:10.1093/ajcn/84.5.1193

Cited by 110 publications

(101 citation statements)

References 38 publications

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“…In fact, for healthy human subjects and animal, moderate weight loss did not necessarily translate to changes in the plasma adiponectin level. 23,24 For subjects with metabolic abnormalities, weight loss larger than 10% was needed to change plasma adiponectin levels. 25 Also, patients with defective growth hormone receptor showed elevated plasma adiponectin despite marked obesity.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between body mass index and plasma adiponectin levels in healthy adults

Kuo

2011

Int J Obes

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Objectives: To test the hypothesis that obesity (increase in fat mass) independently affects the level of adipokines: adiponectin, tumor necrosis factor-a (TNFa) and interleukin (IL)-6. Methods: Publications in the past decade reporting adult plasma adiponectin, leptin, TNFa and/or IL-6 levels were compiled. Mean gender-specific values were extracted from studies that included medical screening to confirm physical health (43 groups, total 4852 subjects). Correlation analysis was conducted between adipokine levels and body mass index (BMI), a widely used estimate of adiposity. Results: For healthy lean to obese adults of both genders, no significant correlation between plasma adiponectin and BMI was detected. There was also no gender difference in plasma adiponectin level. In contrast, leptin levels showed a positive correlation with BMI in both genders, and women had significantly higher levels of plasma leptin consistent with a higher percentage of body fat. The proinflammatory cytokine TNFa failed to show correlation with BMI. Although IL-6 showed a positive correlation with BMI in women, the obesity-related increase was very limited. Conclusions: Data analysis based on studies performed on healthy adults did not support the hypothesis that obesity independently affects the plasma level of adiponectin and TNFa. Reported obesity-related changes in plasma adipokine levels may be a consequence of obesity-related metabolic disorders. Future studies are especially needed to understand the homeostasis of adiponectin.

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Section: Introductionmentioning

confidence: 99%

Lack of association between body mass index and plasma adiponectin levels in healthy adults

Kuo

2011

Int J Obes

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“…only ADIPO was an independent BMD predictor in postmenopausal women and middle-aged men [47][48][49][50]. Other authors found that both LP and ADIPO were determinants of BMD; RES was negatively correlated with BMD, but the correlation did not reach statistical significance (p = 0.062) [51].…”

Section: Prace Oryginalnementioning

confidence: 93%

“…OC concentrations were also positively correlated with ADIPO [43][44][45][46]. OPG concentrations were higher in a premenopausal than in a postmenopausal population [47][48][49]. The OPG/RANKL ratio correlated negatively with LP and positively with ADIPO independent of age, BMI and the time elapsed from menopause [45].…”

Section: Introductionmentioning

confidence: 99%

Metabolizm kostny, osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB a wybrane hormony tkanki tłuszczowej u dziewcząt z jadłowstrętem psychicznym

Ostrowska¹,

Ziora²,

Oświęcimska³

et al. 2014

Endokrynologia Polska

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“…Other researchers demonstrated a decrease [49] or increase [50][51][52] of VISF concentrations in obese subjects. According to some authors [43,[85][86][87][88][89][90], the association between LP, ADIPO, RES and VISF and obesity is lent support by changes in adipocytokine concentrations following weight reduction (diet or surgery) in individuals with moderate or severe obesity. Significant weight reduction in women with moderate or severe obesity, apparently resulting from dietary treatment, has been found to be associated with decreased LP and RES and increased ADIPO circulating concentrations [85][86][87].…”

Section: Prace Oryginalnementioning

confidence: 99%

“…According to some authors [43,[85][86][87][88][89][90], the association between LP, ADIPO, RES and VISF and obesity is lent support by changes in adipocytokine concentrations following weight reduction (diet or surgery) in individuals with moderate or severe obesity. Significant weight reduction in women with moderate or severe obesity, apparently resulting from dietary treatment, has been found to be associated with decreased LP and RES and increased ADIPO circulating concentrations [85][86][87]. Weight loss after bariatric surgery in women and/or men with morbid obesity was associated with decreased LP, RES, VISF and increased ADIPO levels [43,[88][89][90].…”

Section: Prace Oryginalnementioning

confidence: 99%

Wybrane hormony tkanki tłuszczowej, metabolizm kostny a osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u otyłych kobiet po menopauzie

Ostrowska

Świętochowska

Marek

et al. 2015

Endokrynologia Polska

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Selected adipose tissue hormones, bone metabolism, osteoprotegerin and receptor activator of nuclear factor-kB ligand in postmenopausal obese women Wybrane hormony tkanki tłuszczowej, metabolizm kostny a osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u otyłych kobiet po menopauzie AbstractIntroduction: It has been suggested that changes in the production of adipose tissue hormones in obese postmenopausal women might affect their bone status. The aim of this study was to determine whether obese postmenopausal women exhibited any relationship between serum levels of LP, ADIPO, RES, VISF, APE and bone metabolism markers (OC and CTx), OPG, sRANKL, the OPG/sRANKL ratio as well as BMD. Material and methods: 80 postmenopausal women (60 obese and 20 healthy) underwent BMD measurement using dual-energy X-ray absorptiometry (DXA) at lumbar spine L 2 -L 4 . Serum levels of selected adipose tissue hormones, OC, CTx, OPG and its soluble ligand, sRANKL, were assessed by ELISA. Results:Obese postmenopausal women demonstrated a significant increase in body mass, BMI and WHR associated with significant increases in LP and RES levels, a decrease in ADIPO concentration, suppression of OC, CTx, OPG and sRANKL and an increase in the OPG/sRANKL ratio and BMD. BMI correlated positively with BMD, LP, RES, OPG and the OPG/sRANKL ratio, whereas in the case of ADIPO, OC, CTx, sRANKL the relationship was negative. WHR was positively correlated with the OPG/sRANKL ratio, and negatively with ADIPO and APE. A positive correlation was found between BMD and LP, APE and the OPG/sRANKL ratio, while the correlation between BMD and ADIPO, CTx, sRANKL was negative. Significant positive correlations were also revealed between OC, CTx and ADIPO; OPG and ADIPO; sRANKL and ADIPO, RES; the OPG/sRANKL ratio and LP. OC correlated negatively with LP, RES, VISF, APE; CTx with LP, VISF, APE; OPG with LP; sRANKL with LP and APE; the OPG/sRANKL ratio with VISF. ADIPO was an independent predictor of OC, OPG and sRANKL, while LP turned out to be an independent predictor of CTx, OPG, sRANKL and the OPG/sRANKL ratio. Conclusions: Obesity in postmenopausal women can lead to changes in BMD, circulating levels of bone markers, OPG, sRANKL and/or the OPG/sRANKL ratio; these changes are associated with alterations in the concentrations of adipose tissue hormones under investigation. The relationships between bone status indicators and adipose tissue hormones, especially LP and ADIPO, seem to suggest that changes in these hormones observed in obese postmenopausal women might have a protective effect on bone tissue, most probably via a shift in the OPG/sRANKL ratio towards a functional excess of OPG. (Endokrynol Pol 2014; 65 (6): 438-448)

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Interrelations between fat distribution, muscle lipid content, adipocytokines, and insulin resistance: effect of moderate weight loss in older women

Cited by 110 publications

References 38 publications

Lack of association between body mass index and plasma adiponectin levels in healthy adults

Lack of association between body mass index and plasma adiponectin levels in healthy adults

Metabolizm kostny, osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB a wybrane hormony tkanki tłuszczowej u dziewcząt z jadłowstrętem psychicznym

Wybrane hormony tkanki tłuszczowej, metabolizm kostny a osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB u otyłych kobiet po menopauzie

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