Interrelations of Apoptotic and Cellular Senescence Genes Methylation in Inflammatory Bowel Disease Subtypes and Colorectal Carcinoma in Egyptians Patients

Salama, Ragaa H. M.; Sayed, Zain El-Abdeen Ahmed; Ashmawy, Ahmed M; Elsewify, Wael Abd-Elgwad; Ezzat, Ghada M; Mahmoud, Mahmoud; Alsanory, Aya A; Alsanory, Tasneem A

doi:10.1007/s12010-019-03017-x

Cited by 5 publications

(8 citation statements)

References 45 publications

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“…As far as we could know, there are no studies about p14/ARF methylation and family history of breast cancer in hazardous women was reported, and our results are a preliminary report and enormous planned investigations are needed. Previously, p14/ARF methylation studies reported that to be not linked to the cancer family history in Indian breast cancer patients [21], and Egyptian colorectal cancer patients [13], however, change in DNA methylation due to a family history of breast cancer had been confirmed by several studies. Scott et al [22] investigated blood DNA methylation in Australian women with BRCA1-like earlyonset breast cancer and indicated that higher methylation of BRCA-1 promoter in those women than non-BRCA mutation carrier women.…”

Section: Discussionmentioning

confidence: 97%

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Determinants of p14/ARF methylation in healthy females: association with reproductive and non-reproductive risk factors of breast cancer

Ezzat

El-Shoeiby

2019

Egypt J Med Hum Genet

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Background: DNA methylation is associated with the risk factors of breast cancer. However, the impact of the reproductive and non-reproductive risk factors of breast cancer on p14/ARF methylation is not well known. Therefore, we investigated the relationships between p14/ARF methylation percentage and risk factors of breast cancer including age, family history, obesity, and reproductive risk factors in 120 breast cancer-free subjects; 60 women with a firstdegree family history of breast cancer and 60 age-matched women with no family history of breast cancer. Extracted DNA from the whole blood was bisulfite-treated by EZ DNA modification kit. Quantitative methylation of p14/ARF was analyzed by methylation-specific PCR then methylation percentage of p14/ARF was calculated. Results: P14/ARF methylation percentage was not related to any of the risk factors of breast cancer except age. Our study showed that p14/ARF methylation percentage was significantly higher in females with age ≥ 40 years than in females with age < 40 years (p=0.029). Also, a positive significant correlation between the p14/ARF methylation percentage and age was detected (r = 0.285, p = 0.014). Furthermore, univariate regression analysis showed that the age is independently associated with high p14/ARF methylation percentage (β = 1. 46, p = 0.029).

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Section: Discussionmentioning

confidence: 97%

“…P14/ARF gene was reported to be aberrantly methylated in the blood of patients with many cancers including colon cancer [13], lung cancer, and leukemia [14]. The results of previous studies about p14/ARF methylation in breast cancer were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Determinants of p14/ARF methylation in healthy females: association with reproductive and non-reproductive risk factors of breast cancer

Ezzat

El-Shoeiby

2019

Egypt J Med Hum Genet

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“…The identification of novel markers of senescence may assist in the prognosis of senescence and cancer. Various other biomarkers of senescence have been identified and are listed in Table I (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41).…”

Section: Senescence Biomarkersmentioning

confidence: 99%

“…and p53. P14 (ARF) is one of the two proteins encoded by the CDKN2A, the other of which is p16 INK4a , and is an important inducer of cellular senescence (39). The p14 (ARF) protein is expressed at low levels in normal cells, but is markedly increased as the cells reach senescence.…”

Section: Adp-ribosylation Factor (Arf) Double Minute 2 (Mdm2)mentioning

confidence: 99%

Possibility of inducing tumor cell senescence during therapy (Review)

et al. 2021

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“…Indeed, it has been reported that in patients with CRC, a high number of senescent cells are associated with a poor prognosis, underlining how a high concentration of senescent cells favors tumor progression. The senescent cells initially can play a protective anti-tumor effect, but this can become pro-carcinogenic over time and with changes in the microenvironment conditions [27,29,31,[49][50][51][52].…”

Section: Introductionmentioning

confidence: 99%

Clostridioides difficile Toxin B Induced Senescence: A New Pathologic Player for Colorectal Cancer?

Fettucciari

Fruganti

Stracci

et al. 2023

IJMS

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Clostridioides difficile (C. difficile) is responsible for a high percentage of gastrointestinal infections and its pathological activity is due to toxins A and B. C. difficile infection (CDI) is increasing worldwide due to the unstoppable spread of C. difficile in the anthropized environment and the progressive human colonization. The ability of C. difficile toxin B to induce senescent cells and the direct correlation between CDI, irritable bowel syndrome (IBS), and inflammatory bowel diseases (IBD) could cause an accumulation of senescent cells with important functional consequences. Furthermore, these senescent cells characterized by long survival could push pre-neoplastic cells originating in the colon towards the complete neoplastic transformation in colorectal cancer (CRC) by the senescence-associated secretory phenotype (SASP). Pre-neoplastic cells could appear as a result of various pro-carcinogenic events, among which, are infections with bacteria that produce genotoxins that generate cells with high genetic instability. Therefore, subjects who develop IBS and/or IBD after CDI should be monitored, especially if they then have further CDI relapses, waiting for the availability of senolytic and anti-SASP therapies to resolve the pro-carcinogenic risk due to accumulation of senescent cells after CDI followed by IBS and/or IBD.

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Interrelations of Apoptotic and Cellular Senescence Genes Methylation in Inflammatory Bowel Disease Subtypes and Colorectal Carcinoma in Egyptians Patients

Cited by 5 publications

References 45 publications

Determinants of p14/ARF methylation in healthy females: association with reproductive and non-reproductive risk factors of breast cancer

Determinants of p14/ARF methylation in healthy females: association with reproductive and non-reproductive risk factors of breast cancer

Possibility of inducing tumor cell senescence during therapy (Review)

Clostridioides difficile Toxin B Induced Senescence: A New Pathologic Player for Colorectal Cancer?

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