Interrelationship between Ethanol Consumption and Circadian Rhythm

Geller, Irving; Purdy, Robert H.

doi:10.1007/978-1-4684-3450-7_23

Cited by 6 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first relates specifically to lighting. Gross experimental manipulation of the lighting cycle (e.g., constant light, constant dark) reportedly alters the drinking behavior of rats (Burke and Kramer, 1974; Geller, 1971; Geller and Purdy, 1979), although a lack of adequate control groups (Sinclair and Geller, 1972) leaves these studies open to alternative interpretations. In general support of this proposition, Experiment 3 showed increased drinking of HAP2 and LAP2 mice in T24 compared to DD (Fig.…”

Section: Discussionmentioning

confidence: 99%

Ethanol consumption in mice: relationships with circadian period and entrainment

Trujillo

David

Grahame

et al. 2011

Alcohol

View full text Add to dashboard Cite

A functional connection between the circadian timing system and alcohol consumption is suggested by multiple lines of converging evidence. Ethanol consumption perturbs physiological rhythms in hormone secretion, sleep and body temperature, and conversely, genetic and environmental perturbations of the circadian system can alter alcohol intake. A fundamental property of the circadian pacemaker, the endogenous period of its cycle under free-running conditions, was previously shown to differ between selectively bred High- (HAP) and Low- (LAP) Alcohol Preferring replicate 1 mice. To test whether there is a causal relationship between circadian period and ethanol intake, we induced experimental, rather than genetic, variations in free-running period. Male inbred C57Bl/6J mice and replicate 2 male and female HAP2 and LAP2 mice were entrained to light:dark cycles of 26 h or 22 h or remained in a standard 24 h cycle. Upon discontinuation of the light:dark cycle, experimental animals exhibited longer and shorter free-running periods, respectively. Despite robust effects on circadian period and clear circadian rhythms in drinking, these manipulations failed to alter the daily ethanol intake of the inbred strain or selected lines. Likewise, driving the circadian system at long and short periods produced no change in alcohol intake. In contrast with replicate 1 HAP and LAP lines, there was no difference in free-running period between ethanol naïve HAP2 and LAP2 mice. HAP2 mice, however, were significantly more active than LAP2 mice as measured by general home-cage movement and wheel running, a motivated behavior implicating a selection effect on reward systems. Despite a marked circadian regulation of drinking behavior, the free-running and entrained period of the circadian clock does not determine daily ethanol intake.

show abstract

Section: Discussionmentioning

confidence: 99%

Ethanol consumption in mice: relationships with circadian period and entrainment

Trujillo

David

Grahame

et al. 2011

Alcohol

View full text Add to dashboard Cite

show abstract

“…We then evaluate how these scheduled histories affect ethanol intake when it is available 24 hours/day. Experiment 2 replicates and extends Experiment 1 by employing “skeleton” photoperiods to remove the potentially confounding factor of light exposure (Geller and Purdy, 1979), and further tests whether the timing, per se, of ethanol exposure (versus amount previously consumed) is critical in setting subsequent levels of self‐administration. Lastly, we also monitor patterns of ethanol drinking during 24‐hour ad lib access to determine how the circadian rhythm is altered by prior drinking history.…”

mentioning

confidence: 97%

“…Conversely, alcohol consumption may feed back on the circadian pacemaker (Rosenwasser et al., 2005a,b). In addition to endogenous factors, some environmental factors, such as light can acutely affect ethanol intake and thereby contribute to the daily rhythm (Geller and Purdy, 1979).…”

mentioning

confidence: 99%

Circadian Timing of Ethanol Exposure Exerts Enduring Effects on Subsequent Ad Libitum Consumption in C57 Mice

Trujillo

Roberts

Gorman

2009

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Background There is a daily rhythm in the voluntary intake of ethanol in mice, with greatest consumption in the early night and lowest intake during the day. The role of daily timing of ethanol exposure on the development and control of long-term ethanol self-administration has been neglected. The present study examines these issues using C57BL/6J mice. Methods Mice were repeatedly exposed to 10% ethanol for 2 h early in the night or day for several weeks. Subsequently, ethanol was available at the opposite time (Expt 1) or 24 h daily (Expts 1 and 2). Lick sensors recorded the patterns of drinking activity in Experiment 2. Results Mice exposed to ethanol during the night drink more than mice exposed during the day. Prior history did not affect ethanol intake when the schedule was reversed. Under 24 hour exposure conditions, mice with a history of drinking during the night consumed significantly more than mice drinking during the day. The circadian patterns of drinking were not altered. Conclusions These results demonstrate that the daily timing of ethanol exposure exerts enduring effects of self-administration of ethanol in mice. Understanding how circadian rhythms regulate ethanol consumption may be valuable for modifying subsequent intake.

show abstract

“…The s-LN v s send widespread projections throughout the Drosophila brain, and terminals of these neurons lie close to Crz neuron cell bodies in the pars lateralis (Kaneko and Hall, 2000;Choi et al, 2005), suggesting a possible functional connection through which the circadian clock can modulate ethanol-induced sedation. Dorsal terminals of the circadian PDF neurons also arborize near the pars intercerebralis soma, suggestive of circadian modulation of arousal and sleep-promoting neurons within the pars intercerebralis (Gorostiza et al, 2014). Thus, the anatomical interactions from circadian pacemaker cells to the pars intercerebralis and the pars lateralis provide a mechanism for circadian modulation of alcohol sedation.…”

Section: Discussionmentioning

confidence: 92%

“…Circadian differences in recovery from the deleterious effects of alcohol abuse may influence time-of-day drinking preferences or binge drinking. Time-of-day drinking preferences for alcohol have been long established in rodent models (Geller, 1971; Geller and Purdy, 1979; Wasielewski and Holloway, 2001; Trujillo et al, 2011) and humans (Arfken, 1988; Danel et al, 2003). The evening preference for alcohol consumption is exacerbated by an evening chronotype as individuals categorized as evening types display greater alcohol consumption and increased risks of alcohol abuse and binge drinking (Prat and Adan, 2011; Urbán et al, 2011; Watson et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Circadian Modulation of Alcohol-Induced Sedation and Recovery in Male and Female Drosophila

Nobrega

Lyons

2016

J Biol Rhythms

View full text Add to dashboard Cite

Delineating the factors that affect behavioral and neurological responses to alcohol is critical to facilitate measures for preventing or treating alcohol abuse. The high degree of conserved molecular and physiological processes make Drosophila melanogaster a valuable model for investigating circadian interactions with alcohol-induced behaviors and examining sex-specific differences in alcohol sensitivity. We found that wild-type Drosophila exhibit rhythms in alcohol-induced sedation under light-dark and constant dark conditions with considerably greater alcohol exposure necessary to induce sedation during the late (subjective) day and peak sensitivity to alcohol occurring during the late (subjective) night. The circadian clock also modulated the recovery from alcohol-induced sedation with flies regaining motor control significantly faster during the late (subjective) day. As predicted, the circadian rhythms in sedation and recovery were absent in flies with a mutation in the circadian gene period or arrhythmic flies housed in constant light conditions. Flies lacking a functional circadian clock were more sensitive to the effects of alcohol with significantly longer recovery times. Similar to other animals and humans, Drosophila exhibit sex-specific differences in alcohol sensitivity. We investigated whether the circadian clock modulated the rhythms in the Loss-of-Righting Reflex, alcohol-induced sedation, and recovery differently in males and females. We found that both sexes demonstrate circadian rhythms in the Loss-of-Righting Reflex and sedation with the differences in alcohol sensitivity between males and females most pronounced during the late subjective day. Recovery of motor reflexes following alcohol sedation also exhibited circadian modulation in male and female flies, although the circadian clock did not modulate the difference in recovery times between the sexes. These studies provide a framework outlining how the circadian clock modulates alcohol-induced behaviors in Drosophila and identifies sexual dimorphisms in the circadian modulation of alcohol behaviors.

show abstract

Interrelationship between Ethanol Consumption and Circadian Rhythm

Cited by 6 publications

References 28 publications

Ethanol consumption in mice: relationships with circadian period and entrainment

Ethanol consumption in mice: relationships with circadian period and entrainment

Circadian Timing of Ethanol Exposure Exerts Enduring Effects on Subsequent Ad Libitum Consumption in C57 Mice

Circadian Modulation of Alcohol-Induced Sedation and Recovery in Male and Female Drosophila

Contact Info

Product

Resources

About