1978
DOI: 10.2165/00003088-197803010-00004
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Interrelationship Between Renal Haemodynamics, Drug Kinetics and Drug Action

Abstract: The renal haemodynamics of a particular patient may affect the pharmacological and pharmacokinetic properties of various drugs. For example, diminution in renal haemodynamics may lead to fluid retention and an increase in the volume of distribution fif the drug. A Iso, fluid retention causes a decrease in plasma protein concentration which for certain drugs can result in altered protein binding and consequent~v increased proportion of unbound drug and a more marked pharmacological response.The clearance fif ma… Show more

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Cited by 16 publications
(9 citation statements)
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“…) cates that the total clearance of cimetidine can be altered and be dependent upon changes in renal haemodynamics, e.g. by age, disease or drugs (Duchin and Schrier, 1978).…”
Section: Analytical Methods For Determination In Biological Fluidsmentioning
confidence: 99%
“…) cates that the total clearance of cimetidine can be altered and be dependent upon changes in renal haemodynamics, e.g. by age, disease or drugs (Duchin and Schrier, 1978).…”
Section: Analytical Methods For Determination In Biological Fluidsmentioning
confidence: 99%
“…Renal function, including removal of endogenous and of exogenous compounds, depends at least in part on renal blood flow, or more precisely on plasma flow [14]. A physiological model of renal drug clearance should, therefore, primarily reflect the anatomical arrangement of the blood supply to the nephron as the basic functional unit of the kidney.…”
Section: Serial Model Of Renal Drug Clearancementioning
confidence: 99%
“…The kidney does have a modest capacity for autoregulation, and when renal blood flow is moderately reduced (10 to 20%), the glomerular filtration rate does not fall. However, further reductions in renal blood flow lower the glomerular filtration rate and consequently slow the excretion of drugs cleared by filtration, such as procainamide and digoxin (Duchin and Schrier, 1978). The tubular reabsorption of drugs may be increased as a consequence of decreased urine flow accompanying a decrease in glomerular filtration rate, as well as by sympathetically mediated shunting of blood from cortical to juxtamedullary nephrons (see fig.…”
Section: Effects On Drug Excretionmentioning
confidence: 99%