Interrelationship of Thyroid Hormones, Obesity, and Prolactin in Infertile Women

Kataria, Juhi; Gill, Gurpreet Kaur; Kaur, Manbir

doi:10.22159/ajpcr.2018.v11i1.20861

Cited by 7 publications

(7 citation statements)

References 2 publications

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“…Our data suggest a relationship of Vitamin D and BMI in PCOS women, which is in agreement with many studies [8,13,14]. Other studies suggest that low Vitamin D levels are related to impaired glucose clearance, insulin secretion, and insulin resistance [15,16].…”

Section: Discussionsupporting

confidence: 93%

Effect of Vitamin D Supplementation on Insulin Sensitivity and Androgen Level in Vitamin D-Deficient Polycystic Ovary Syndrome Patients

Al-Thuwaynee

Ahmed

2018

Asian J Pharm Clin Res

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Objectives: There is limited evidence that giving Vitamin D supplementation had a beneficial effect on insulin resistance and dysfunction of the menstrual cycle in females with polycystic ovary syndrome (PCOS). Thus, the aim of the present study is to evaluate the effect of Vitamin D supplementation on insulin sensitivity and androgen level in Iraqi females with PCOS. Methods:A randomized, blinded clinical trial design studied 60 Iraqi females with PCOS referring to the women's counseling, outpatients at maternity and pediatrics teaching hospital in AL-Qadisiyah city, Iraq, and private clinic. Non-probabilistic sampling involved women aged from 18 to 45 years established on inclusion criteria. The patients' basic data have been recorded. Then, we measured Vitamin D, testosterone level, and impaired glucose tolerance (IGT) test to all females. After the diagnosis of Vitamin D deficiency, Vitamin D was administering at 5000 units daily for 8 weeks. All data were remeasured after 2 months.Result: A total of 60 patients with polycystic syndrome enrolled in the study, age range from 18 to 39 years, mean age 27.48±5.95 years. The metabolic parameter have been checked at the beginning of the study, which include Vitamin D level 16.1±5.6, impaired glucose test reading 8.8±0.7 and testosterone level 4.5±0.64.. After 2 months of supplementation, there were 83.7% of patients reach the normal level of Vitamin D and 16.3% still had a low level of Vitamin D (p≤0.002) between two groups. In regard to IGT test after 2 months of supplementation, there were 51.6% of patients still who had impaired test while 48.4% reach the normal reading (p≤0.001). Conclusions:Women with PCOS have a statically significant low level of Vitamin D in mean, IGT test in the mean, and high level of testosterone, and there were inverse correlations between Vitamin D with IGT and testosterone.

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Section: Discussionsupporting

confidence: 93%

Effect of Vitamin D Supplementation on Insulin Sensitivity and Androgen Level in Vitamin D-Deficient Polycystic Ovary Syndrome Patients

Al-Thuwaynee

Ahmed

2018

Asian J Pharm Clin Res

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“…Adding more a low-functioning thyroid gland is prevalent in females, resulting in a significant percentage of infertility, repeated miscarriages, preterm delivery, placenta previa, irregular menstrual cycles, and unexplained weight loss or gain [7,8]. The majority of infertile women have hypothyroidism and hyperprolactinemia that may correlate with infertility [9]. Research shows that hypothyroidism may contribute to the morbidity of osteoporosis, hyperlipidemia, hypercholesterolemia, cardiac disease, asthma, and neuropsychiatric disorder [10].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Knowledge, Attitude, and Practice Regarding Hypothyroidism Among Infertile Women With Hypothyroidism

2020

Asian J Pharm Clin Res

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Objective: The study was designed to assess the knowledge, attitude, and practice (KAP) of hypothyroidism among infertile women with hypothyroidism. Methods: A cross-sectional analysis was performed in an outpatient environment of infertility centers. We used a validated questionnaire to assess hypothyroidism KAP. Using frequency counts (n) and percentages (%), discrete data were summarized. The Chi-square/Fisher test was used between groups to compare. Results: The mean age of participants was found to be 32±5.77 years. It was found that 72% of the subjects had poor knowledge, 44% were extremely concerned, and 81% were practicing with a moderate level of precaution. Among the consequences of hypothyroidism, 68% of the study subjects most properly-recognized menstrual disturbance, followed by 66%, 51%, and 48% of study subject properly-recognized weight gain, fatigue, and muscle aches/pain as a clinical manifestation of hypothyroidism. Most patients (98%) adhered to their medications. Nearly half of the study patients (45%) did not avoid cabbage, cauliflower, or soya. Conclusion: Our study highlighted the significance of investing appropriate time to provide patients with a comprehensive education to bridge the gaps in patient care. The findings also indicated that it be better for the understanding of the patients if health-care providers could provide patients with data sheets explaining the disease or having some pictorial/pamphlets about the disease’s reality and myths.

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“…Prolactin (PRL) is a type of polypeptide hormone secreted by the anterior pituitary gland. PRL is balanced by PRL releasing factor (PRF) and PRL inhibiting hormone (PIH) [ 15 , 16 ]. In the normal physiological condition, the increased transcription activity of GATA1 induces the transcription of its downstream CSN5 gene, leading to the upregulation of CSN5.…”

Section: Discussionmentioning

confidence: 99%

Bu-Shen-Zhu-Yun decoction induces PRLR deubiquitination and JAK2/STAT5 activation via CSN5 in vitro

Huang

Zhou

Lü

et al. 2021

Aging

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Purpose: To determine the effect of Bu-Shen-Zhu-Yun Decoction (BSZY-D) on the kisspeptin through JAK2/STAT5 signaling pathway in hyperprolactinemia (HPRL) infertility. Method: SD rats were treated with BSZY-D for cerebrospinal fluid (CSF) extraction. GT1-7 cells were subjected to different treatments. The phosphorylation levels of JAK2 and STAT5, and the expressions of PRLR and kisspeptin of GT1-7 cells in different groups were detected by western blot, RT-qPCR and immunofluorescence. The expressions of CSN5 and GATA1 and other molecular features were checked by western blot, RT-PCR, co-immunoprecipitation and renilla luciferase activity. Results: The phosphorylation levels of JAK2 and STAT5, and the expressions of PRLR and kisspeptin in the HPRL group were significantly decreased, and these changes could be reversed after BSZY-D treatment. In addition, the presence of PRLR deubiquitination was detected in the HPRL group, which could be reversed by shRNA-CSN5, suggesting that BSZY-D played a role through targeting CSN5. The binding level of GATA1 and CSN5 promoter in the HPRL group was significantly decreased, but elevated in the HPRL (BSZY-D/CSF) group (P < 0.05). Conclusion: BSZY-D improved the transcription activity of GATA1 and increased the binding of GATA1 and CSN5. BSZY-D was involved in the deubiquitination of PRLR, which contributes to alleviating the symptoms of HPRL infertility.

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Interrelationship of Thyroid Hormones, Obesity, and Prolactin in Infertile Women

Cited by 7 publications

References 2 publications

Effect of Vitamin D Supplementation on Insulin Sensitivity and Androgen Level in Vitamin D-Deficient Polycystic Ovary Syndrome Patients

Effect of Vitamin D Supplementation on Insulin Sensitivity and Androgen Level in Vitamin D-Deficient Polycystic Ovary Syndrome Patients

Assessment of Knowledge, Attitude, and Practice Regarding Hypothyroidism Among Infertile Women With Hypothyroidism

Bu-Shen-Zhu-Yun decoction induces PRLR deubiquitination and JAK2/STAT5 activation via CSN5 in vitro

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