Interrelationships between depressive symptoms and positive and negative symptoms of recent onset schizophrenia spectrum disorders: A network analytical approach

Herniman, Sarah E.; Phillips, Lisa; Wood, Stephen; Cotton, Sue; Liemburg, Edith J.; Allott, Kelly

doi:10.1016/j.jpsychires.2021.05.038

Cited by 18 publications

(14 citation statements)

References 48 publications

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“…In keeping with the present results, a recent longitudinal study in an FEP sample found that depression was one of the most important nodes in their network [43] and further revealed that it maintained its central role at the 12-month follow-up despite the amelioration of psychotic symptoms [46]. The topographic proximity of depressive to positive symptoms in our network is also consistent with previous findings [5,43,48] and constitutes an alert that potential worsening of the affective domain could translate to a flare up of psychotic symptoms [43] and vice versa. However, their networks did not include general psychopathology, so the present study raises the possibility that other nodes may underlie these relationships.…”

Section: Bridges Nodessupporting

confidence: 93%

Searching for bridges between psychopathology and real-world functioning in first-episode psychosis: A network analysis from the OPTiMiSE trial

et al. 2022

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Background. Network analysis has been used to explore the interplay between psychopathology and functioning in psychosis, but no study has used dedicated statistical techniques to focus on the bridge symptoms connecting these domains. The current study aims to estimate the network of depressive, negative, and positive symptoms, general psychopathology, and real-world functioning in people with first-episode schizophrenia or schizophreniform disorder, focusing on bridge nodes. Methods. Baseline data from the OPTiMiSE trial were analyzed. The sample included 446 participants (age 40.0 AE 10.9 years, 70% males). The network was estimated with a Gaussian graphical model, using scores on individual items of the positive and negative syndrome scale (PANSS), the Calgary depression scale for schizophrenia, and the personal and social performance scale. Stability, strength centrality, expected influence (EI), predictability, and bridge centrality statistics were computed. The top 20% scoring nodes on bridge strength were selected as bridge nodes. Results. Nodes from different rating scales assessing similar psychopathological and functioning constructs tended to cluster together in the estimated network. The most central nodes (EI) were Delusions, Emotional Withdrawal, Depression, and Depressed Mood. Bridge nodes included Depression, Conceptual Disorganization, Active Social Avoidance, Delusions, Stereotyped Thinking, Poor Impulse Control, Guilty Feelings, Unusual Thought Content, and Hostility. Most of the bridge nodes belonged to the general psychopathology subscale of the PANSS. Depression (G6) was the bridge node with the highest value. Conclusions. The current study provides novel insights for understanding the complex phenotype of psychotic disorders and the mechanisms underlying the development and maintenance of comorbidity and functional impairment after psychosis onset.

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Section: Bridges Nodessupporting

confidence: 93%

Searching for bridges between psychopathology and real-world functioning in first-episode psychosis: A network analysis from the OPTiMiSE trial

et al. 2022

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“…We also included a group of participants with affective and substance use disorders who did not meet CHR-P criteria (CHR-N) in addition to non-clinical control participants (HC). There is evidence that hippocampal changes also occur in several other psychiatric syndromes, including major depressive disorder ( Arnone et al, 2012 ) as well as substance abuse ( Wilson et al, 2017 , Wang et al, 2021 ) and there is substantial comorbidity between affective disorders, substance abuse and early-stage psychosis ( Li et al, 2020 , Wilson et al, 2017 , Herniman et al, 2021 ). Finally, we investigated the relationship between hippocampal volumes and clinical features, including global functioning and cognition, and the persistence of attenuated psychotic symptoms (APS) to determine whether hippocampal changes correlate with clinical and functional outcomes in CHR-P participants.…”

Section: Introductionmentioning

confidence: 99%

Hippocampal structural alterations in early-stage psychosis: Specificity and relationship to clinical outcomes

Brunner

Gajwani

Groß

et al. 2022

NeuroImage: Clinical

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“…Moreover, the results on the relationships between self-reflectiveness/composite index and negative symptoms are consistent with previous studies. Several studies have reported that self-reflectiveness was closely associated with negative affect, such as depression and anxiety ( 43 , 46 , 48 – 51 ), which have strong associations with negative symptoms ( 52 – 54 ). Sagayadevan et al ( 55 ) also reported that psychiatric outpatients with higher self-reflectiveness scored higher on the environment domain but lower on the social relationships domain of quality of life.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Cognitive and Clinical Insight at Different Durations of Untreated Attenuated Psychotic Symptoms in High-Risk Individuals

Zhang

Wang³

et al. 2021

Front. Psychiatry

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Background: This study examines whether cognitive insight is impaired in high-risk individuals with attenuated psychotic symptoms (APS) and explores the relationship between cognitive and clinical insight at different durations of untreated attenuated psychotic symptoms (DUAPS).Methods: The Structured Interview for Psychosis high-risk Syndrome (SIPS) was used to identify APS individuals. APS (n = 121) and healthy control (HC, n = 87) subjects were asked to complete the Beck Cognitive Insight Scale (BCIS). Clinical insight of APS individuals was evaluated using the Schedule for Assessment of Insight (SAI). APS individuals were classified into four subgroups based on DUAPS, including 0–3, 4–6, 7–12, and >12 months. Power analysis for significant correlation was conducted using the WebPower package in R.Results: Compared with HC subjects, APS individuals showed poorer cognitive insight, with lower scores on BCIS self-reflectiveness and composite index (BCIS self-reflectiveness minus BCIS self-certainty). Only when DUAPS was longer than 12 months did the significant positive correlation between cognitive and clinical insight obtain the power about 0.8, including the associations between self-reflectiveness and awareness of illness, self-reflectiveness and the total clinical insight, and composite index and awareness of illness. The positive associations of composite index with awareness of illness within 0–3 months DUAPS and with the total score of SAI when DUAPS > 12 months were significant but failed to obtain satisfactory power.Conclusions: APS individuals may have impaired cognitive insight, demonstrating lower self-reflectiveness. The correlation between cognitive and clinical insight is associated with the duration of untreated attenuated psychotic symptoms.

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Interrelationships between depressive symptoms and positive and negative symptoms of recent onset schizophrenia spectrum disorders: A network analytical approach

Cited by 18 publications

References 48 publications

Searching for bridges between psychopathology and real-world functioning in first-episode psychosis: A network analysis from the OPTiMiSE trial

Searching for bridges between psychopathology and real-world functioning in first-episode psychosis: A network analysis from the OPTiMiSE trial

Hippocampal structural alterations in early-stage psychosis: Specificity and relationship to clinical outcomes

Relationship Between Cognitive and Clinical Insight at Different Durations of Untreated Attenuated Psychotic Symptoms in High-Risk Individuals

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