Interrelationships between Ionizing Radiation, Protein Synthesis, and the Physiological Expressions of Radiation Damage

Oleinick, Nancy L.; Rustad, Ronald C.

doi:10.1016/b978-0-12-035406-1.50008-7

Cited by 11 publications

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Exposure of phosphocellulose-purified 6S tubulin to ionizing radiation results in a reduction or loss in its ability to participate in polymerization. Evidence is presented which -A. number of theories have been proposed to explain the mitotic delay which occurs following exposure of cultured cells to ionizing radiation (Oleinick & Rustad 1976;Okada, 1970a); however, none satisfactorily accounts for all of the observed results. Many of the studies which were performed to elucidate the target site of the damage concentrated on measurement of the rates of DNA, RNA, or protein synthesis following irradiation (Bacchetti & Sinclair, 1970Sinclair, ,1971Doida & Okada, 1969;Tomasovic & Dewey, 1978).

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Effects of ionizing radiation on the polymerization of microtubules in vitro

Zaremba¹,

Irwin²

1981

Biochemistry

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Effects of ionizing radiation on the polymerization of microtubules in vitro

Zaremba¹,

Irwin²

1981

Biochemistry

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PROTEIN SYNTHESIS AND RADIATION-INDUCED MITOTIC DELAY11Supported in part by the U.S. Energy Research and Development Administration contract EY-76-S-02–2486 and by Support for Radiation Oncology Research grant no. CA 19283 awarded by the National Cancer Institute, D.H.E.W.

Rustad¹

1978

Cell Reproduction

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The Participation of Elevated Levels of Cyclic GMP in the Recovery from Radiation-induced Mitotic Delay

Daniel

Oleinick

1984

International Journal of Radiation Biology and Related Studies

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The levels of cyclic AMP and cyclic GMP have been measured in Physarum plasmodia before and after treatment with gamma-radiation, 2 mM caffeine, or combinations of the two agents and compared to the length of the radiation-induced mitotic delay. Caffeine alone produces a rapid transient elevation of cyclic AMP and a slower delayed elevation of cyclic GMP. Irradiation elicits an immediate transient increase in cyclic AMP and a later cyclic GMP increase which accompanies or precedes the delayed mitosis. A composite pattern is produced by combinations of radiation and caffeine, a distinctive feature of which is an elevated level of cyclic GMP near the time of the radiation-delayed and caffeine-promoted mitosis. With pretreatment by caffeine, the least radiation-induced mitotic delay occurs when plasmodia are irradiated during the caffeine-elicited increase in cyclic GMP. The plasmodium becomes refractory to the reduction of mitotic delay by caffeine at approximately the time it becomes refractory to the further elevation of cyclic GMP by caffeine. The data support a role for cyclic AMP in the onset of and for cyclic GMP in the recovery from mitotic delay induced by ionizing radiation.

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Interrelationships between Ionizing Radiation, Protein Synthesis, and the Physiological Expressions of Radiation Damage

Cited by 11 publications

References 310 publications

Effects of ionizing radiation on the polymerization of microtubules in vitro

Effects of ionizing radiation on the polymerization of microtubules in vitro

PROTEIN SYNTHESIS AND RADIATION-INDUCED MITOTIC DELAY11Supported in part by the U.S. Energy Research and Development Administration contract EY-76-S-02–2486 and by Support for Radiation Oncology Research grant no. CA 19283 awarded by the National Cancer Institute, D.H.E.W.

The Participation of Elevated Levels of Cyclic GMP in the Recovery from Radiation-induced Mitotic Delay

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