Interrelationships Between Periodontal Disease and Mortality, Cardiovascular Disease, Metabolic Syndrome, Diabetes Mellitus

Dumitrescu, Alexandrina L.; Inagaki, Koji

doi:10.1007/978-3-642-03010-9_4

Cited by 5 publications

(5 citation statements)

References 161 publications

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“…These patients, aged between 15-54 show that Periodontitis is exhibited 60% of diabetic patients, while 36% in non-diabetics. [18] Similarly, the Gullah African American population, 70.6% of diabetic patients expressed moderate levels of Periodontitis. [19] Environmental Factors regarding the relationship Specific environments allow the risk of acquiring Periodontitis and type 2 diabetes more likely, and both diseases may be related when attained.…”

Section: Triggered Hyperglycemia From Diabetes To Initiated Periodontmentioning

confidence: 99%

“…Pathological evidence in the progression of Periodontitis suggests that patients develop this infection through prolonged exposure to hyperglycemia and in those with poor glycemic control. [18] Saremi and Associates studying the Pima Indian concluded in their research that death rates related to Periodontal disease is higher in those with diabetes than with those with no diabetes and Periodontal disease. Essentially, within the Pima Indian population in Southern Arizona, patients with type 2 diabetes exhibit more risk factors, including the effects of Periodontitis.…”

Section: Triggered Hyperglycemia From Diabetes To Initiated Periodontmentioning

confidence: 99%

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Periodontitis in Patients with Type 2 Diabetes Mellitus

Agarwal¹,

Gangaram²,

Saleem³

2018

AIMDR

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Periodontitis is a chronic, inflammatory disease that is characterized by swollen gums, degradation of jaw structure, and potentially tooth loss. Like Periodontitis, Type 2 Diabetes Mellitus is also highly prevalent and largely multifactorial. Type 2 Diabetes is a condition in which higher than normal blood glucose levels cannot be properly maintained as the body's normal mechanism of maintaining proper blood glucose levels, the release of insulin from pancreatic islet β-cells, becomes ineffective. The purpose of this literature review is to explore the relationship between the incidences of Periodontitis and Type 2 Diabetes. The risk that Type 2 Diabetes poses for the incidence of Periodontitis is analyzed. Patients afflicted with Type 2 Diabetes were found to be approximately three times as likely to eventually suffer from Periodontitis, as well. There is also emerging evidence supporting the correlation between the degree of hyperglycemia and severity of Periodontitis. Potential underlying mechanisms linking the two conditions at the cellular level have been discussed. Immune functioning and cytokine biology are among discussed mechanisms. Recent discoveries have also suggested that Periodontitis may also negatively impact glycemic control. As a result, not only should healthcare providers emphasize oral health as part of Type 2 Diabetes management, but healthy eating and physical activity should be among recommendations that make up Periodontal management.

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Section: Triggered Hyperglycemia From Diabetes To Initiated Periodontmentioning

confidence: 99%

Section: Triggered Hyperglycemia From Diabetes To Initiated Periodontmentioning

confidence: 99%

Periodontitis in Patients with Type 2 Diabetes Mellitus

Agarwal¹,

Gangaram²,

Saleem³

2018

AIMDR

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“…Periodontal diseases are a group of oral inflammatory diseases that are influenced by host response factors. In the last decades, there was a consensus toward the [1][2][3] converse relationship between periodontal disease and systemic disease. Evidence suggest that periodontal disease is an independent risk-factor for a number of significant systemic diseases so much so that they have brought a shift in the rationale about causality and the directionality of oral and systemic [4,5] associations.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Level of TNF-α in Chronic Periodontitis Patients with Gestational Diabetes Mellitus after Phase I Periodontal Therapy

Elkadi¹,

Madkour²,

El-Menoufy³

et al. 2018

Dentistry

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the healthy periodontium. It contains different substances including: immunoglobulin, microorganisms, toxins, cells, and lysosomal enzymes and markers. GCF is regarded as a window for non-invasive analysis of periodontal [11-14] conditions, including markers of connective tissue and bone destruction. Evaluation of the molecular markers of tissue destruction in serum was sought to clarify the possible interactions between periodontitis and various systemic diseases and conditions such as gestational diabetes mellitus GDM and adverse pregnancy outcomes). Serum provides information about the inflammatory stimulus and the response generated in circulation towards the periodontal [15,16]. Pathogens that colonize the sub-gingival area. The present study was conducted to evaluate the levels of TNF-α in GCF and serum in chronic periodontitis patients with or without GDM before and after phase I (non-surgical) periodontal therapy and its correlation to periodontal clinical parameters.

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“…Periodontal diseases are a group of oral inflammatory diseases that are influenced by host response factors. In the last decades, there was a consensus toward the [1][2][3] converse relationship between periodontal disease and systemic disease. Evidence suggest that periodontal disease is an independent riskfactor for a number of significant systemic diseases so much so that they have brought a shift in the rationale about causality and the directionality of oral and systemic [4,5] associations.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Level of TNF- α In Chronic Periodontitis Patients with Gestational Diabetes Mellitus after Phase I Periodontal Therapy

Elkadi

2018

ADOH

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When adipose tissue inflammation and dysfunction are established, adipokine secretion is significantly changed toward a diabetogenic, proinflammatory and atherogenic pattern. TNF-α is a pro-inflammatory cytokine that plays a central role in inflammatory reaction, alveolar bone resorption, and the loss of connective tissue attachment. It is positively correlated with Matrix metalloproteinases (MMPs), Prostaglandin E2 (PGE2) and nuclear factor kappa [8-10] ligand (RANKL) expression.

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Interrelationships Between Periodontal Disease and Mortality, Cardiovascular Disease, Metabolic Syndrome, Diabetes Mellitus

Cited by 5 publications

References 161 publications

Periodontitis in Patients with Type 2 Diabetes Mellitus

Periodontitis in Patients with Type 2 Diabetes Mellitus

Evaluation of Level of TNF-α in Chronic Periodontitis Patients with Gestational Diabetes Mellitus after Phase I Periodontal Therapy

Evaluation of Level of TNF- α In Chronic Periodontitis Patients with Gestational Diabetes Mellitus after Phase I Periodontal Therapy

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